Journal ArticleDOI
Anticancer compounds derived from fungal endophytes: their importance and future challenges.
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TLDR
This is a review of anticancer agents isolated from endophytic fungi from 1990–2010, based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines.About:
This article is published in Natural Product Reports.The article was published on 2011-06-22. It has received 458 citations till now. The article focuses on the topics: Plant use of endophytic fungi in defense.read more
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Chemical Ecology of Endophytic Fungi: Origins of Secondary Metabolites
TL;DR: The possible current and future strategies of understanding the chemical communication of endophytic fungi with other endophytes and with their host plants might not only allow the discovery and sustainable production of desirable natural products but also other mostly overlooked bioactive secondary metabolites.
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Natural Products as a Vital Source for the Discovery of Cancer Chemotherapeutic and Chemopreventive Agents.
Gordon M. Cragg,John M. Pezzuto +1 more
TL;DR: Given the unfathomable diversity of nature, it is reasonable to suggest that chemical leads can be generated that are capable of interacting with most or possibly all therapeutic targets.
Journal ArticleDOI
Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites
TL;DR: The review reveals the importance of endophytic fungi from medicinal plants as a source of bioactive and chemically novel compounds for use in the pharmaceutical and agrochemical industries.
References
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疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1）与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Fibroblasts in cancer
TL;DR: Fibroblasts are a key determinant in the malignant progression of cancer and represent an important target for cancer therapies.
Journal ArticleDOI
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
Journal ArticleDOI
Promotion of microtubule assembly in vitro by taxol
TL;DR: It is reported here that taxol acts as a promoter of calf brain microtubule assembly in vitro, in contrast to plant products such as colchicine and podophyllotoxin, which inhibit assembly.
Journal ArticleDOI
Natural Products as Sources of New Drugs over the Period 1981−2002
TL;DR: From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well, and in the area of cancer, the percentage of small molecule, new chemical entities that are nonsynthetic has remained at 62% averaged over the whole time frame.
Related Papers (5)
Taxol and Taxane Production by Taxomyces andreanae, an Endophytic Fungus of Pacific Yew
Bioprospecting for Microbial Endophytes and Their Natural Products
Gary A. Strobel,Bryn Daisy +1 more