Journal ArticleDOI
Antimicrobial peptides as an opportunity against bacterial diseases.
Stefania Galdiero,Annarita Falanga,Rita Berisio,Paolo Grieco,Giancarlo Morelli,Massimiliano Galdiero +5 more
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TLDR
AMPs are a group of unique and incredible compounds that may be directed to a therapeutic use either alone or in combination with existing antibiotics.Abstract:
Antimicrobial peptides (AMPs) are an heterogeneous group of small amino acidic molecules produced by the innate immune system of a variety of organisms encompassing all orders of life from eukaryotes to amphibians, insects and plants. Numerous AMPs have been isolated from natural sources and many others have been de novo designed and synthetically produced. AMPs have antimicrobial activity in the micromolar range and compared with traditional antibiotics, they kill bacteria very rapidly. They act, principally, by the electrostatic attraction to negatively charged bacterial cells and consequently membrane disruption, but their antibacterial activity may also involve interference with metabolic processes or different cytoplasmic targets. AMPs are a group of unique and incredible compounds that may be directed to a therapeutic use either alone or in combination with existing antibiotics.read more
Citations
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Antimicrobial peptides: new hope in the war against multidrug resistance
TL;DR: A review highlights multidrug resistance among nosocomial bacterial pathogens and its implications and reiterates the importance of AMPs as next-generation antibiotics for combating MDR superbugs.
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Microbial Diseases of Bivalve Mollusks: Infections, Immunology and Antimicrobial Defense
Carla Zannella,Francesco Mosca,Francesca Mariani,Gianluigi Franci,Veronica Folliero,Marilena Galdiero,Pietro Giorgio Tiscar,Massimiliano Galdiero +7 more
TL;DR: A substantial consideration will be devoted in outlining the immune responses of bivalves and their repertoire of immune cells, and the description of antimicrobial peptides that have been identified and characterized in bivalve mollusks will focus on.
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Marine Antimicrobial Peptides: Nature Provides Templates for the Design of Novel Compounds against Pathogenic Bacteria
Annarita Falanga,Lucia Lombardi,Gianluigi Franci,Mariateresa Vitiello,Maria Rosaria Iovene,Giancarlo Morelli,Massimiliano Galdiero,Stefania Galdiero,Stefania Galdiero +8 more
TL;DR: This review is an attempt to explore marine AMPs as a rich source of molecules with antimicrobial activity, and suggests that these peptides may act as templates for the design of more potent and less toxic compounds.
Journal ArticleDOI
Molecular Dynamics Simulations Are Redefining Our View of Peptides Interacting with Biological Membranes.
TL;DR: This Account shows that in silico molecular dynamics will finally fulfill its promise to become an inexpensive, powerful, and easy-to-use tool providing atomic-detail insights to researchers as part of their investigations into membrane biophysics and beyond.
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Toxicity Effects of Functionalized Quantum Dots, Gold and Polystyrene Nanoparticles on Target Aquatic Biological Models: A Review
Giovanni Libralato,Emilia Galdiero,Annarita Falanga,Rosa Carotenuto,Elisabetta de Alteriis,Marco Guida +5 more
TL;DR: The impact of quantum dots (QDs), gold nanoparticles (AuNPs), and polystyrene-cored NPs (PSNPs) is reviewed, evidencing the role of NP functionalization in toxicity definition.
References
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Antimicrobial peptides of multicellular organisms
TL;DR: As the need for new antibiotics becomes more pressing, could the design of anti-infective drugs based on the design principles these molecules teach us?
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Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
TL;DR: In this review the different models of antimicrobial-peptide-induced pore formation and cell killing are presented and several observations suggest that translocated peptides can alter cytoplasmic membrane septum formation, inhibit cell-wall synthesis, inhibit nucleic-acid synthesis, inhibits protein synthesis or inhibit enzymatic activity.
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Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies.
TL;DR: The role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses gives these peptides the potential to become an entirely new therapeutic approach against bacterial infections.
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Mechanisms of Antimicrobial Peptide Action and Resistance
TL;DR: The intention of this review is to illustrate the contemporary structural and functional themes among mechanisms of antimicrobial peptide action and resistance.
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Peptide Antimicrobial Agents
TL;DR: The structural requirements of peptides for antiviral and antibacterial activities are evaluated in light of the diverse set of primary and secondary structures described for host defense peptides.