Antimicrobial Peptides Derived From Insects Offer a Novel Therapeutic Option to Combat Biofilm: A Review.
Alaka Sahoo,Shasank S. Swain,Ayusman Behera,Gunanidhi Sahoo,Pravati Kumari Mahapatra,Sujogya Kumar Panda +5 more
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TLDR
Antimicrobial peptides (AMPs) have a broad spectrum of activity and the potential to bypass the resistance mechanisms of classical antibiotics as mentioned in this paper, and they may well act synergistically with classical antibiotics for a double-pronged attack on infections.Abstract:
Biofilms form a complex layer with defined structures, that attach on biotic or abiotic surfaces, are tough to eradicate and tend to cause some resistance against most antibiotics. Several studies confirmed that biofilm-producing bacteria exhibit higher resistance compared to the planktonic form of the same species. Antibiotic resistance factors are well understood in planktonic bacteria which is not so in case of biofilm producing forms. This may be due to the lack of available drugs with known resistance mechanisms for biofilms. Existing antibiotics cannot eradicate most biofilms, especially of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). Insects produce complex and diverse set of chemicals for survival and defense. Antimicrobial peptides (AMPs), produced by most insects, generally have a broad spectrum of activity and the potential to bypass the resistance mechanisms of classical antibiotics. Besides, AMPs may well act synergistically with classical antibiotics for a double-pronged attack on infections. Thus, AMPs could be promising alternatives to overcome medically important biofilms, decrease the possibility of acquired resistance and treatment of multidrug-resistant pathogens including ESKAPE. The present review focuses on insect-derived AMPs with special reference to anti-biofilm-based strategies. It covers the AMP composition, pathways and mechanisms of action, the formation of biofilms, impact of biofilms on human diseases, current strategies as well as therapeutic options to combat biofilm with antimicrobial peptides from insects. In addition, the review also illustrates the importance of bioinformatics tools and molecular docking studies to boost the importance of select bioactive peptides those can be developed as drugs, as well as suggestions for further basic and clinical research.read more
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Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics
Jayaseelan Murugaiyan,P. Anand Kumar,G . Srinivasa Rao,Katia Iskandar,Stephen Hawser,John P. Hays,Yara Mohsen,Saranya Adukkadukkam,W. A. Awuah,Ruiz Alvarez Maria Jose,Nanono Sylvia,Esther Nansubuga,Bruno Tilocca,Paola Roncada,Natalia Roson-Calero,Javier Moreno-Morales,Rohul Amin,Ballamoole Krishna Kumar,Abishek Kumar,Abdul-Rahman Toufik,Thaint Nadi Zaw,O Akinwotu,Maneesh Paul Satyaseela,Maarten M. Van Dongen +23 more
TL;DR: In this article , the authors present a review of the strategies that are being applied or proposed as potential alternatives to traditional antibiotics, including combination therapy, techniques that target the enzymes or proteins responsible for antimicrobial resistance, resistant bacteria, drug delivery systems, physicochemical methods and unconventional techniques, including the CRISPR-Cas system.
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The Role of Antimicrobial Peptides as Antimicrobial and Antibiofilm Agents in Tackling the Silent Pandemic of Antimicrobial Resistance
Bruno S. Lopes,Alfizah Hanafiah,Ramesh Nachimuthu,Saravanan Muthupandian,Zarith Nameyrra Md Nesran,Sandip S. Patil +5 more
TL;DR: This review summarises the role of antimicrobial peptides (AMPs) in combating the silent pandemic of AMR and their application in clinical medicine, focusing on both the advantages and disadvantages of AMPs as antibiofilm agents.
Journal ArticleDOI
Prevention, inhibition, and degradation effects of melittin alone and in combination with vancomycin and rifampin against strong biofilm producer strains of methicillin-resistant Staphylococcus epidermidis.
Rasoul Mirzaei,MY Alikhani,Carla Renata Arciola,Iraj Sedighi,Rasoul Yousefimashouf,Kamran Pooshang Bagheri +5 more
TL;DR: In this paper , the antibiofilm activity of melittin, either alone or in combination with vancomycin and rifampin, against biofilm-producing Staphylococcus epidermidis (MRSE) strains was explored using real-time PCR.
Journal ArticleDOI
Inhibition of Zoonotic Pathogens Naturally Found in Pig Manure by Black Soldier Fly Larvae and Their Intestine Bacteria
Osama Elhag,Yuanpu Zhang,X.P. Xiao,Minmin Cai,Longyu Zheng,Heather R. Jordan,Jeffery K. Tomberlin,Feng Huang,Ziniu Yu,Jibin Zhang +9 more
TL;DR: Results clearly showed that zoonotic pathogens in pig manure were significantly decreased after being treated with BSF larvae, and suggested that the antimicrobial peptides produced by the B SF larvae and gut-associated bacteria are able to antagonize the zoonosis pathogens.
Journal ArticleDOI
Development of Novel Peptides for the Antimicrobial Combination Therapy against Carbapenem-Resistant Acinetobacter baumannii Infection.
TL;DR: In this article, PapMA-3 with Trp18 showed the highest bacterial selectivity against Acinetobacter baumannii (CRAB) infection, alongside low cytotoxicity.
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