Journal ArticleDOI
APACHE II-A Severity of Disease Classification System: Reply
TLDR
The form and validation results of APACHE II, a severity of disease classification system, are presented, showing an increasing score was closely correlated with the subsequent risk of hospital death for 5815 intensive care admissions from 13 hospitals.Abstract:
This paper presents the form and validation results of APACHE II, a severity of disease classification system. APACHE II uses a point score based upon initial values of 12 routine physiologic measurements, age, and previous health status to provide a general measure of severity of disease. An increasing score (range 0 to 71) was closely correlated with the subsequent risk of hospital death for 5815 intensive care admissions from 13 hospitals. This relationship was also found for many common diseases.When APACHE II scores are combined with an accurate description of disease, they can prognostically stratify acutely ill patients and assist investigators comparing the success of new or differing forms of therapy. This scoring index can be used to evaluate the use of hospital resources and compare the efficacy of intensive care in different hospitals or over time.read more
Citations
More filters
Journal ArticleDOI
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock
Emanuel P. Rivers,Bryant Nguyen,Suzanne Havstad,Julie Ressler,Alexandria Muzzin,Bernhard P. Knoblich,Edward L. Peterson,Michael C. Tomlanovich +7 more
TL;DR: This study randomly assigned patients who arrived at an urban emergency department with severe sepsis or septic shock to receive either six hours of early goal-directed therapy or standard therapy (as a control) before admission to the intensive care unit.
Journal ArticleDOI
Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group.
TL;DR: A 2-day consensus conference on acute renal failure (ARF) in critically ill patients was organized by ADQI as discussed by the authors, where the authors sought to review the available evidence, make recommendations and delineate key questions for future studies.
Journal ArticleDOI
Efficacy and safety of recombinant human activated protein C for severe sepsis.
G Ordon R. B Ernard,J Ean L Ouis V Incent,L Aterre,S Teven P. L A R Osa,J Ean,A Ngel L Opez,J Ay S. S Teingrub,G Ary E. G Arber,J Effrey,D. H Elterbrand,E. W Esley E Ly,C Harles J. F Isher,S Evere S Epsis,S Tudy G Roup +13 more
TL;DR: This phase 3 trial assessed whether treatment with drotrecogin alfa activated reduced the rate of death from any cause among patients with severe sepsis.
Journal ArticleDOI
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock.
Anand Kumar,Daniel Roberts,Kenneth E. Wood,Bruce Light,Joseph E. Parrillo,Satendra Sharma,Robert Suppes,Daniel Feinstein,Sergio Zanotti,Leo Taiberg,David A. Gurka,Aseem Kumar,Mary Cheang +12 more
TL;DR: Effective antimicrobial administration within the first hour of documented hypotension was associated with increased survival to hospital discharge in adult patients with septic shock.
Journal ArticleDOI
Acinetobacter baumannii: Emergence of a Successful Pathogen
TL;DR: This review details the significant advances that have been made in understanding of this remarkable organism over the last 10 years, including current taxonomy and species identification, issues with susceptibility testing, mechanisms of antibiotic resistance, global epidemiology, clinical impact of infection, host-pathogen interactions, and infection control and therapeutic considerations.
References
More filters
Journal ArticleDOI