Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
Charles Frost,Jessie Wang,Sunil Nepal,Alan Schuster,Yu Chen Barrett,Rogelio Mosqueda-Garcia,Richard A. Reeves,Frank LaCreta +7 more
TLDR
To evaluate apixaban single dose safety, tolerability, pharmacokinetics and pharmacodynamics and assess the effect of food on Apixaban pharmacokinetically, a large number of animals were tested.Abstract:
Aims
To evaluate apixaban single dose safety, tolerability, pharmacokinetics and pharmacodynamics and assess the effect of food on apixaban pharmacokinetics.read more
Citations
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Effect of renal impairment on the pharmacokinetics, pharmacodynamics, and safety of apixaban
Ming Chang,Zhigang Yu,Andrew Shenker,Jessie Wang,Janice Pursley,Wonkyung Byon,Rebecca A. Boyd,Frank P. LaCreta,Charles Frost +8 more
TL;DR: The results suggest that dose adjustment of apixaban is not required on the basis of renal function alone and that the drug was well tolerated in this study.
Journal ArticleDOI
Effect of ketoconazole and diltiazem on the pharmacokinetics of apixaban, an oral direct factor Xa inhibitor
Charles Frost,Wonkyung Byon,Yan Song,Jessie Wang,Alan Schuster,Rebecca A. Boyd,Donglu Zhang,Zhigang Yu,Clapton Dias,Andrew Shenker,Frank LaCreta +10 more
TL;DR: Apixaban maximum plasma concentration and area under the plasma concentration-time curve extrapolated to infinity increased by 62% and 99%, respectively, with co-administration of ketoconazole and diltiazem, respectively.
Journal ArticleDOI
Effect of Activated Charcoal on Apixaban Pharmacokinetics in Healthy Subjects
Xiaoli Wang,Sabiha A. Mondal,Jessie Wang,Giridhar S. Tirucherai,Donglu Zhang,Rebecca A. Boyd,Charles Frost +6 more
TL;DR: Results suggest that activated charcoal may be useful in the management of apixaban overdose or accidental ingestion, andAdministration of activated charcoal up to 6 h after apixban reduced apixaba exposure and facilitated the elimination of apIXaban.
Journal ArticleDOI
Guidelines for Gastroenterological Endoscopy in Patients Undergoing Antithrombotic Treatment: 2017 Appendix on Anticoagulants Including Direct Oral Anticoagulants.
Mototsugu Kato,Noriya Uedo,Seiji Hokimoto,Masahiro Ieko,Kazuhide Higuchi,Kazunari Murakami,Kazuma Fujimoto +6 more
TL;DR: New findings regarding anticoagulants are included in this appendix, however, the evidence levels are low for many statements contained herein and these appended guidelines still need to be verified in clinical settings.
Journal ArticleDOI
Pharmacology of anticoagulants used in the treatment of venous thromboembolism
TL;DR: This paper will summarize the key pharmacologic properties of the anticoagulant agents used in the treatment of patients with VTE.
References
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Journal ArticleDOI
Apixaban versus Warfarin in Patients with Atrial Fibrillation
Christopher B. Granger,John H. Alexander,Renato D. Lopes,Elaine M. Hylek,Michael G. Hanna,Hussein R. Al-Khalidi,Jack Ansell,Dan Atar,Alvaro Avezum,M. Cecilia Bahit,Rafael Diaz,J. Donald Easton,Justin A. Ezekowitz,Greg C. Flaker,David A. Garcia,Margarida Geraldes,Bernard J. Gersh,Sergey P. Golitsyn,Shinya Goto,Antonio G. Hermosillo,Stefan H. Hohnloser,John D. Horowitz,Puneet Mohan,Petr Jansky,Basil S. Lewis,Jose Lopez-Sendon,Prem Pais,Alexander Parkhomenko,Jun Zhu,Lars Wallentin +29 more
TL;DR: In patients with atrial fibrillation, apixaban was superior to warfarin in preventing stroke or systemic embolism, caused less bleeding, and resulted in lower mortality.
Journal ArticleDOI
Apixaban in Patients with Atrial Fibrillation
Stuart J. Connolly,John W. Eikelboom,Campbell D. Joyner,Hans-Christoph Diener,Robert G. Hart,Sergey P. Golitsyn,Greg C. Flaker,Alvaro Avezum,Stefan H. Hohnloser,Rafael Diaz,Mario Talajic,Jun Zhu,Prem Pais,Andrzej Budaj,Alexander Parkhomenko,Petr Jansky,Patrick J. Commerford,Ru San Tan,Kui-Hian Sim,Basil S. Lewis,Walter Van Mieghem,Jae Hyung Kim,Fernando Lanas-Zanetti,Antonio Gonzalez-Hermosillo,Antonio L. Dans,Muhammad Munawar,John H. Lawrence,Gayle Lewis,Rizwan Afzal,Salim Yusuf +29 more
TL;DR: In patients with atrial fibrillation for whom vitamin K antagonist therapy was unsuitable, apixaban reduced the risk of stroke or systemic embolism without significantly increasing therisk of major bleeding or intracranial hemorrhage.
Journal ArticleDOI
Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).
TL;DR: Guyatt et al. as mentioned in this paper presented the pharmacokinetics and pharmacodynamics of vitamin K antagonists (VKAs) and provided specific management recommendations for the first 1 or 2 days for most individuals.
Journal ArticleDOI
Apixaban versus enoxaparin for thromboprophylaxis after knee replacement (ADVANCE-2): a randomised double-blind trial
TL;DR: Apixaban 2.5 mg twice daily, starting on the morning after total knee replacement, offers a convenient and more effective orally administered alternative to 40 mg per day enoxaparin, without increased bleeding.
Journal ArticleDOI
Apixaban versus Enoxaparin for Thromboprophylaxis after Hip Replacement
Michael R. Lassen,Alexander Gallus,Gary E. Raskob,Graham F. Pineo,Dalei Chen,Luz Margarita Ramirez +5 more
TL;DR: Among patients undergoing hip replacement, thromboprophylaxis with apixaban, as compared with enoxaparin, was associated with lower rates of venous thromboembolism, without increased bleeding.
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