Applications of indocyanine green in brain tumor surgery: review of clinical evidence and emerging technologies.
Clare W Teng,Clare W Teng,Vincent Huang,Vincent Huang,Gabriel R Arguelles,Gabriel R Arguelles,Cecilia Zhou,Cecilia Zhou,Steve S. Cho,Stefan Harmsen,John Y K Lee +10 more
TLDR
A review of ICG-guided surgery of intracranial tumors can be found in this paper, where the authors provide an overview of the literature related to ICG in neuro-oncological surgeries, including ICG fluorescence in the NIR-II window; ICG for photoacoustic imaging; and ICG nanoparticles for combined diagnostic imaging and therapy (theranostic) applications.Abstract:
Indocyanine green (ICG) is a water-soluble dye that was approved by the FDA for biomedical purposes in 1956. Initially used to measure cardiocirculatory and hepatic functions, ICG's fluorescent properties in the near-infrared (NIR) spectrum soon led to its application in ophthalmic angiography. In the early 2000s, ICG was formally introduced in neurosurgery as an angiographic tool. In 2016, the authors' group pioneered a novel technique with ICG named second-window ICG (SWIG), which involves infusion of a high dose of ICG (5.0 mg/kg) in patients 24 hours prior to surgery. To date, applications of SWIG have been reported in patients with high-grade gliomas, meningiomas, brain metastases, pituitary adenomas, craniopharyngiomas, chordomas, and pinealomas.The applications of ICG have clearly expanded rapidly across different specialties since its initial development. As an NIR fluorophore, ICG has advantages over other FDA-approved fluorophores, all of which are currently in the visible-light spectrum, because of NIR fluorescence's increased tissue penetration and decreased autofluorescence. Recently, interest in the latest applications of ICG in brain tumor surgery has grown beyond its role as an NIR fluorophore, extending into shortwave infrared imaging and integration into nanotechnology. This review aims to summarize reported clinical studies on ICG fluorescence-guided surgery of intracranial tumors, as well as to provide an overview of the literature on emerging technologies related to the utility of ICG in neuro-oncological surgeries, including the following aspects: 1) ICG fluorescence in the NIR-II window; 2) ICG for photoacoustic imaging; and 3) ICG nanoparticles for combined diagnostic imaging and therapy (theranostic) applications.read more
Citations
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Recent advances and trends in nanoparticles based photothermal and photodynamic therapy
Ayuob Aghanejad,Soodabeh Davaran +1 more
TL;DR: In this paper , the basic principles of photodynamic therapy (PDT) and photothermal therapy (PTT) with their strengths and limitations to treat cancers are discussed. And the authors also discuss light-based nanoparticles and their PTT and PDT applications in the preclinical and clinical translation.
Journal ArticleDOI
Antibody-conjugated liposomes loaded with indocyanine green for oral targeted photoacoustic imaging-guided sonodynamic therapy of Helicobacter pylori infection.
TL;DR: In this paper , a monoclonal antibody-conjugated nanoliposome loaded with indocyanine green (ICG) was successfully developed for targeted photoacoustic (PA) imaging-guided sonodynamic therapy (SDT) of H. pylori infection in vivo.
Journal ArticleDOI
Near-Infrared Window II Fluorescence Image-Guided Surgery of High-Grade Gliomas Prolongs the Progression-Free Survival of Patients
TL;DR: In this article , the authors investigated the clinical benefits of indocyanine green (ICG) based near-infrared window II (NIR-II) fluorescence image-guided surgery (FGS) on high-grade glioma (HGG) patients.
Journal ArticleDOI
Phage Particles of Controlled Length and Genome for In Vivo Targeted Glioblastoma Imaging and Therapeutic Delivery.
TL;DR: The ability to modulate the capsid display, surface loading, phage length, and cssDNA gene content makes the recombinant M13 phage particle an ideal delivery platform.
Journal ArticleDOI
Deuterated Indocyanine Green (ICG) with Extended Aqueous Storage Shelf-Life: Chemical and Clinical Implications.
Dong-Hao Li,Bradley D. Smith +1 more
TL;DR: In this article, two deuterated versions of ICG were prepared with deuterium atoms on the heptamethine chain, and the spectral, physiochemical, and photostability properties were quantified.
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