Journal ArticleDOI
Applications of thermal analysis and coupled techniques in pharmaceutical industry
TLDR
The current use of thermal analysis and combined techniques in research and development and in production is reviewed and the advantage of commercially coupled techniques to thermogravimetry is emphasized with some examples.Abstract:
Thermal analysis methods are well-established techniques in research laboratories of pharmaceutical industry. The robustness and sensitivity of instrumentation, the introduction of automation and of reliable software according to the industrial needs widened considerably the areas of applications inthe last decade. Calibration of instruments and validation of results follow the state of the art of cGMP as for other analytical techniques. Thermal analysis techniques are especially useful for the study of the behavior of the poly-phasic systems drug substances and excipients and find a unique place for new delivery systems. Since change of temperature and moisture occur by processing and storage, changes of the solid state may have a considerable effect on activity, toxicity and stability of compounds. Current requirements of the International Conference of Harmonisation for the characterization and the quantitation of polymorphism in new entities re-enforce the position of thermal analysis techniques. This challenging task needs the use of complementary methods. Combined techniques and microcalorimetry demonstrate their advantages. This article reviews the current use of thermal analysis and combined techniques in research and development and in production. The advantage of commercially coupled techniques to thermogravimetry is emphasized with some examples.read more
Citations
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Journal ArticleDOI
Stability studies on nifedipine tablets using thermogravimetry and differential scanning calorimetry
TL;DR: In this article, a formulation of nifedipine tablets was prepared in amber-colored glass containers and placed in a climatized room at 40°C and relative humidity of 75% for 180 days.
Physicochemical study of CaCO 3 from egg shells Estudo físico-químico do carbonato de cálcio obtido a partir da casca de ovo
Fábio S. Murakami,Patrik Oening Rodrigues,Célia Maria Teixeira de Campos,Marcos Antônio,Segatto Silva +4 more
TL;DR: In this article, the physicochemical and thermal properties of calcium carbonate obtained from egg shells were evaluated, and it was shown that calcium carbonates can be used as an alternative pharmaceutical excipient.
Journal ArticleDOI
Conformational Energy Landscape of the Ritonavir Molecule.
TL;DR: The energy landscape framework is employed to investigate the conformational transitions of an isolated ritonavir molecule and provides mechanistic insight into pathways for cis ↔ trans interconversion at the molecular level and may also help in elucidating the polymorphic transitions in the crystal state.
Journal ArticleDOI
Influence of temperature and humidity on the degradation process of ascorbic acid in vitamin C chewable tablets
Gorica Pavlovska,Stojne Tanevska +1 more
TL;DR: In this paper, the active ingredient of vitamin C chewable tablets was made to protect the active substance with polymers ethyl cellulose that provides thermal protection and protection from moisture, and each particle of AA with a layer of polymer by the method of fluidization.
Journal ArticleDOI
Thermodynamic property values of selected polycyclic aromatic hydrocarbons measured by differential scanning calorimetry
Vikram Kestens,Guy Auclair,Katarzyna Drozdzewska,Andrea Held,Gert Roebben,Thomas P. J. Linsinger +5 more
TL;DR: In this paper, the use of differential scanning calorimetry (DSC) is demonstrated as a powerful technique that can provide accurate thermodynamic property values of environmental contaminants such as polycyclic aromatic hydrocarbons (PAHs).
References
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Book
Enantiomers, Racemates, and Resolutions
TL;DR: RACEMATE and their ENANTIOMER CONSTITUENTS Types of Crystalline Racemates Binary Mixtures of Enantiomers Solution Properties as mentioned in this paper.
Journal ArticleDOI
Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
Bruno C. Hancock,George Zografi +1 more
TL;DR: The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms and some of the most common methods that can be used to measure them are described.
Journal ArticleDOI
Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs
TL;DR: Commercial use of solid dispersion systems during the past four decades has been very limited, primarily because of manufacturing difficulties and stability problems, but this has been changing in recent years because of the availability of surface-active and self-emulsifying carriers and the development of technologies to encapsulate solid dispersions directly into hard gelatin capsules as melts.
Book
Polymorphism in Pharmaceutical Solids
TL;DR: Brittain et al. as mentioned in this paper applied the phase rule to the characterisation of polymorphic and solvatomorphic systems, and proposed a computational method to predict polymorphism.
Book ChapterDOI
Crystalline Polymorphism of Organic Compounds
TL;DR: A wide variety of techniques appropriate to the study of organic crystalline polymorphism and pseu-dopolymorphism is then surveyed, ranging from simple crystal density measurement to observation of polymorphic transformations using variable-temperature synchrotron X-ray diffraction methods.