Journal ArticleDOI
Applications of thermal analysis and coupled techniques in pharmaceutical industry
TLDR
The current use of thermal analysis and combined techniques in research and development and in production is reviewed and the advantage of commercially coupled techniques to thermogravimetry is emphasized with some examples.Abstract:
Thermal analysis methods are well-established techniques in research laboratories of pharmaceutical industry. The robustness and sensitivity of instrumentation, the introduction of automation and of reliable software according to the industrial needs widened considerably the areas of applications inthe last decade. Calibration of instruments and validation of results follow the state of the art of cGMP as for other analytical techniques. Thermal analysis techniques are especially useful for the study of the behavior of the poly-phasic systems drug substances and excipients and find a unique place for new delivery systems. Since change of temperature and moisture occur by processing and storage, changes of the solid state may have a considerable effect on activity, toxicity and stability of compounds. Current requirements of the International Conference of Harmonisation for the characterization and the quantitation of polymorphism in new entities re-enforce the position of thermal analysis techniques. This challenging task needs the use of complementary methods. Combined techniques and microcalorimetry demonstrate their advantages. This article reviews the current use of thermal analysis and combined techniques in research and development and in production. The advantage of commercially coupled techniques to thermogravimetry is emphasized with some examples.read more
Citations
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Journal ArticleDOI
General principles of pharmaceutical solid polymorphism: a supramolecular perspective.
Barbara Rodríguez-Spong,Christopher P. Price,Adivaraha Jayasankar,Adam J. Matzger,Naír Rodríguez-Hornedo +4 more
TL;DR: Current understanding of pharmaceutical solids in terms of molecular recognition and complementarity provides new insights into the design and function of single and fully miscible, multiple-component solids with varying degrees of order, and in this way is leading the path to supramolecular pharmaceutics.
Journal ArticleDOI
Analytical techniques for characterization of cyclodextrin complexes in the solid state: A review.
TL;DR: A general prospect of the principal analytical techniques which can be employed for a suitable characterization of drug-cyclodextrin systems in the solid state, evidencing their respective potential advantages and limits is presented.
Journal ArticleDOI
Pharmaceutical aspects of salt and cocrystal forms of APIs and characterization challenges.
TL;DR: The state‐of‐the‐art on this subject is offered in order to develop new insights and to promote cooperative efforts in the fascinating field of API salt and cocrystal forms.
Journal ArticleDOI
Computational and experimental approaches for investigating nanoparticle-based drug delivery systems
Mohsen Ramezanpour,Sherry S.W. Leung,Karelia H. Delgado-Magnero,Bashe Y. M. Bashe,Jenifer Thewalt,D. P. Tieleman +5 more
TL;DR: This article reviews key biophysical aspects and computational studies for several major categories of nanocarriers, including dendrimers and dendrons, polymer-, peptide-, nucleic acid-, lipid-, and carbon-based DDSs, and gold nanoparticles, and discusses how computer modeling can assist in rational design of D DSs with improved and optimized properties.
Patent
1,2,5-Oxadiazoles As Inhibitors Of Indoleamine 2,3-Dioxygenase
Andrew P. Combs,Eddy W. Yue,Sparks Richard B,Wenyu Zhu,Jiacheng Zhou,Qiyan Lin,Lingkai Weng,Yue Tai-Yuen,Pingli Liu +8 more
TL;DR: In this article, the present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders.
References
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Journal ArticleDOI
Applications of isothermal microcalorimetry in the pharmaceutical sciences
TL;DR: Isothermal heat conduction microcalorimetry is a technique which can be used to study very many physical and chemical processes as mentioned in this paper, which can potentially give information on thermodynamics of the process, kinetics (mechanism) and analysis.
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On application of an isothermal sorption microcalorimeter
TL;DR: In this article, a wide scope of application of a novel isothermal sorption microcalorimeter is presented, which is suitable for the thermodynamic characterization of the sorption process.
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Study of β-blockers/β-cyclodextrins inclusion complex by NMR, DSC, X-ray and SEM investigation
Rita Ficarra,Paola Ficarra,D. Di Bella,D. Raneri,Silvana Tommasini,M. L. Calabrò,Maria Cristina Gamberini,Cecilia Rustichelli +7 more
TL;DR: In this paper, the formation of inclusion complexes between beta-cyclodextrin with the two beta-blockers, atenolol and celiprolol, have been studied in the aqueous environment and in the solid state by nuclear magnetic resonance (NMR) spectroscopy, X-ray, differential scanning calorimetry (DSC) and scanning electron microscopy (SEM) techniques.
Journal ArticleDOI
Conversion in the solid state of the yellow to the red form of 2-(4'-methoxyphenyl)-1,4-benzoquinone. X-ray crystal structures and anisotropy of the rearrangement
Journal ArticleDOI
Thermal Analysis, Microcalorimetry and Combined Techniques for the Study of Pharmaceuticals
TL;DR: In this article, the authors used thermal analysis, microcalorimetry and new emerging combined techniques which deliver calorimetric, microscopic and spectroscopic data offer a powerful analytical battery for the study of pharmaceuticals.