Journal ArticleDOI
Applications of thermal analysis and coupled techniques in pharmaceutical industry
TLDR
The current use of thermal analysis and combined techniques in research and development and in production is reviewed and the advantage of commercially coupled techniques to thermogravimetry is emphasized with some examples.Abstract:
Thermal analysis methods are well-established techniques in research laboratories of pharmaceutical industry. The robustness and sensitivity of instrumentation, the introduction of automation and of reliable software according to the industrial needs widened considerably the areas of applications inthe last decade. Calibration of instruments and validation of results follow the state of the art of cGMP as for other analytical techniques. Thermal analysis techniques are especially useful for the study of the behavior of the poly-phasic systems drug substances and excipients and find a unique place for new delivery systems. Since change of temperature and moisture occur by processing and storage, changes of the solid state may have a considerable effect on activity, toxicity and stability of compounds. Current requirements of the International Conference of Harmonisation for the characterization and the quantitation of polymorphism in new entities re-enforce the position of thermal analysis techniques. This challenging task needs the use of complementary methods. Combined techniques and microcalorimetry demonstrate their advantages. This article reviews the current use of thermal analysis and combined techniques in research and development and in production. The advantage of commercially coupled techniques to thermogravimetry is emphasized with some examples.read more
Citations
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Journal ArticleDOI
Thermal behavior of the β -blocker propranolol
TL;DR: In this paper, the thermal behavior of β-blocker anti-hypertensive drug propranolol was investigated using thermoanalytical techniques TG-DTA, DSC and the evolved gas analysis by TG-FTIR, providing information regarding thermal stability, decomposition steps, melting point and heat of fusion of the compound.
Journal ArticleDOI
Differential scanning calorimetry method for purity determination: A case study on polycyclic aromatic hydrocarbons and chloramphenicol
TL;DR: In this paper, the validity and suitability of differential scanning calorimetry (DSC) to determine the purity of selected polycyclic aromatic hydrocarbons and chloramphenicol has been investigated.
Journal ArticleDOI
Thermal behaviour of antiproliferative active 3-(2-furanyl)-8-aryl-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-ones
TL;DR: In this paper, the thermal behavior of six anticancer active derivatives of 3-(2-furanyl)-8-aryl-7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-one was investigated.
Journal ArticleDOI
Thermal characterization of raw material pentoxifylline using thermoanalytical techniques and Pyr-GC/MS
Agna Hélia de Oliveira,Elisana Afonso de Moura,Márcia Ferraz Pinto,José Valdilânio Virgulino Procópio,Valmir Gomes de Souza,Fábio Santos de Souza,Fábio Santos de Souza,Rui Oliveira Macêdo,Rui Oliveira Macêdo +8 more
TL;DR: In this article, the thermal characterization of the pentoxifylline raw material through thermoanalytical techniques (TG, DSC, and DSC-photovisual) and analysis of degradation products by Pyr-GC/MS was studied.
Journal ArticleDOI
Thermal studies of analgesic active 8-aryl-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-diones
TL;DR: In this article, the determination of thermal stability by investigating the thermal degradation of six analgesic active derivatives of 8-aryl-2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-dione (8-ATHITD) was described.
References
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Book
Enantiomers, Racemates, and Resolutions
TL;DR: RACEMATE and their ENANTIOMER CONSTITUENTS Types of Crystalline Racemates Binary Mixtures of Enantiomers Solution Properties as mentioned in this paper.
Journal ArticleDOI
Characteristics and Significance of the Amorphous State in Pharmaceutical Systems
Bruno C. Hancock,George Zografi +1 more
TL;DR: The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms and some of the most common methods that can be used to measure them are described.
Journal ArticleDOI
Solid dispersion of poorly water‐soluble drugs: Early promises, subsequent problems, and recent breakthroughs
TL;DR: Commercial use of solid dispersion systems during the past four decades has been very limited, primarily because of manufacturing difficulties and stability problems, but this has been changing in recent years because of the availability of surface-active and self-emulsifying carriers and the development of technologies to encapsulate solid dispersions directly into hard gelatin capsules as melts.
Book
Polymorphism in Pharmaceutical Solids
TL;DR: Brittain et al. as mentioned in this paper applied the phase rule to the characterisation of polymorphic and solvatomorphic systems, and proposed a computational method to predict polymorphism.
Book ChapterDOI
Crystalline Polymorphism of Organic Compounds
TL;DR: A wide variety of techniques appropriate to the study of organic crystalline polymorphism and pseu-dopolymorphism is then surveyed, ranging from simple crystal density measurement to observation of polymorphic transformations using variable-temperature synchrotron X-ray diffraction methods.