Journal ArticleDOI
Aqueous ethyl cellulose dispersion containing plasticizers of different water solubility and hydroxypropyl methyl-cellulose as coating material for diffusion pellets II: properties of sprayed films.
TLDR
Results are used to explain the different drug release mechanisms of the coated pellets and to enable the prediction and optimization of drug release-rates from coated pellets.About:
This article is published in European Journal of Pharmaceutics and Biopharmaceutics.The article was published on 1999-07-01. It has received 83 citations till now. The article focuses on the topics: Ethyl cellulose & Plasticizer.read more
Citations
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Journal ArticleDOI
Polymer blends for controlled release coatings.
TL;DR: An overview on the current state of the art of the use of polymer blends as coating materials for controlled drug delivery, explaining the major advantages and potential pitfalls and special emphasis is laid on the underlying drug release mechanisms.
Patent
Controlled release hydrocodone formulations
TL;DR: A solid oral controlled-release dosage form of hydrocodone is described in this article, with the dosage form comprising an analgesically effective amount of the drug or a pharmaceutically acceptable salt thereof, and controlled release material.
Book ChapterDOI
Application of Cellulose and Cellulose Derivatives in Pharmaceutical Industries
Javad Shokri,Khosro Adibkia +1 more
TL;DR: The use of cellulose and cellulose-based polymeric materials has also gained agreat popularity in pharmaceutical industries and become more and more important in this field owing to production of the new derivatives and finding new applications for existed compounds by pharmaceutical researchers as mentioned in this paper.
Journal ArticleDOI
Blends of enteric and GIT-insoluble polymers used for film coating: physicochemical characterization and drug release patterns.
TL;DR: A broad range of drug release patterns from coated pellets could be achieved by varying the GIT-insoluble:enteric polymer blend ratio, and with increasing relative amounts of Eudragit L, the release rates in both media significantly increased.
Journal ArticleDOI
Polymer blends used for the aqueous coating of solid dosage forms: importance of the type of plasticizer.
TL;DR: Interestingly, drug release strongly depended on the type of plasticizer, and the hydrophilicity of the plasticizer significantly affected the water uptake behavior of the film coatings and, hence, changes in the coatings' toughness and drug permeability.
References
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Journal ArticleDOI
Mechanical properties of dry and wet cellulosic and acrylic films prepared from aqueous colloidal polymer dispersions used in the coating of solid dosage forms.
TL;DR: The low permeability of a water-soluble drug, chlorpheniramine maleate, and the weak mechanical properties of Aquacoat films could suggest osmotic driven/rupturing effects as the release mechanisms from aquacoat-coated dosage forms.
Journal ArticleDOI
Influence of water soluble and insoluble plasticizers on the physical and mechanical properties of acrylic resin copolymers
TL;DR: In this article, the effect of different types and levels of plasticizers on the thermal and physical-mechanical properties of equilibrated methacrylic acid copolymers was studied.
Journal ArticleDOI
The Mechanical Properties of Hydroxypropylmethylcellulose Films Derived from Aqueous Systems Part 1: The Influence of Plasticisers
TL;DR: In this article, the effects that certain plasticisers have on the properties of aqueous based HPMC films of a type used for film coating tablets, and investigate whether or not the inclusion of these additives is in fact beneficial in all cases.
Journal ArticleDOI
Kinetics and mechanisms of water sorption in hydrophobic, ionizable copolymer gels
TL;DR: In this paper, the aqueous kinetic swelling properties of a class of cross-linked hydrophobic polyamine copolymer gels based on n-alkyl esters of methacrylic acid (nAMA) and N,N-dimethylaminoethyl methacrylate (DMA) have been studied as a function of solution ionic composition (pH, ionic strength, and buffer content), gel composition, and temperature.
Journal Article
Influence of plasticizer concentration and storage conditions on the drug release rate from Eudragit® RS30D film-coated sustained-release theophylline pellets
Karim Amighi,André Jules Moes +1 more
TL;DR: In this paper, the influence of triethylcitrate (TEC) concentration and storage conditions (temperature and relative humidity) on the release of theophylline from Eudragit® RS30D coated sustained-release pellets has been evaluated.