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Are Inflammatory Factors Related to Retinal Vessel Caliber
Citations
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Journal ArticleDOI
Retinal Vascular Caliber, Cardiovascular Risk Factors, and Inflammation: The Multi-Ethnic Study of Atherosclerosis (MESA)
Tien Yin Wong,Tien Yin Wong,F.M. Amirul Islam,Ronald Klein,Barbara E.K. Klein,Mary Frances Cotch,Cecilia Castro,A. Richey Sharrett,Eyal Shahar +8 more
TL;DR: Retinal arteriolar and venular caliber is associated with a range of cardiovascular risk factors, including hypertension, diabetes, measures of obesity, and dyslipidemia and is also associated with systemic inflammation.
Journal ArticleDOI
Rationale and methodology for a population-based study of eye diseases in Malay people: The Singapore Malay eye study (SiMES).
Athena W.P. Foong,Seang-Mei Saw,Jing-Liang Loo,Sunny Shen,Seng-Chee Loon,Mohamad Rosman,Tin Aung,Donald T.H. Tan,E. Shyong Tai,Tien Yin Wong +9 more
TL;DR: Data from this study allow further understanding of the etiology and impact of eye diseases in this ethnic group and provide population-based data on the prevalence of and risk factors for age-related eye disease in people of Malay ethnicity in Singapore.
Journal ArticleDOI
Retinal vascular caliber: systemic, environmental and genetic associations
Cong Sun,Jie Jin Wang,Jie Jin Wang,David A. Mackey,David A. Mackey,Tien Yin Wong,Tien Yin Wong +6 more
TL;DR: Elucidating the complete range of systemic, environmental, and genetic factors linked with retinal vascular caliber changes may provide critical insight into the etiology, pathogenesis, and natural history of early vascular disease not only in the eye but across the body.
Journal ArticleDOI
Retinal vessel diameter and cardiovascular mortality: pooled data analysis from two older populations
Jie Jin Wang,Gerald Liew,Ronald Klein,Elena Rochtchina,Michael D. Knudtson,Barbara E.K. Klein,Tien Yin Wong,Tien Yin Wong,George Burlutsky,Paul Mitchell +9 more
TL;DR: Retinal vessel diameter may predict risk of CHD and stroke deaths in middle-aged persons and is associated with an increased risk of stroke-mortality among persons aged 43-69.
Journal ArticleDOI
Retinal vascular imaging: a new tool in microvascular disease research.
TL;DR: A review of retinal vascular imaging can be found in this paper, where the role and pathophysiology of the microvasculature of the retinal vasculature is investigated.
References
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Journal ArticleDOI
Methods for evaluation of retinal microvascular abnormalities associated with hypertension/sclerosis in the Atherosclerosis Risk in Communities Study
Larry D. Hubbard,William N. King,Limin X. Clegg,Ronald Klein,Lawton S. Cooper,A. Richey Sharrett,Matthew D. Davis,Jianwen Cai +7 more
TL;DR: Protocols have been developed for nonmydriatic fundus photography and for evaluation of retinal vascular abnormalities in the ARIC Study and several microvascular changes were significantly associated with higher blood pressure, controlling for gender, race, age, and smoking status.
Journal ArticleDOI
Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine.
Gordon Starkebaum,J M Harlan +1 more
TL;DR: It was found that homocysteine plus copper could lyse the cells in a dose-dependent manner, an effect that was completely prevented by catalase, and these findings may be relevant to the mechanism of some types of chronic vascular injury.
Journal ArticleDOI
Revised formulas for summarizing retinal vessel diameters
Michael D. Knudtson,Kristine E. Lee,Larry D Hubbard,Tien Yin Wong,Ronald Klein,Barbara E.K. Klein +5 more
TL;DR: Revised formulas for summarizing retinal vessel diameters measured from fundus photographs are described, which offer the advantages of being more robust against variability in the number of vessels observed, being independent of image scale, and being easier to implement.
Journal ArticleDOI
Retinal arteriolar narrowing and risk of coronary heart disease in men and women. The Atherosclerosis Risk in Communities Study.
Tien Yin Wong,Ronald Klein,A. Richey Sharrett,Bruce Bartholow Duncan,David Couper,James M. Tielsch,Barbara E.K. Klein,Larry D. Hubbard +7 more
TL;DR: Retinal arteriolar narrowing is related to risk of CHD in women but not in men, supporting a more prominent microvascular role in the development of CHd in women than in men.
Journal ArticleDOI
Retinal microvascular abnormalities and incident stroke: the Atherosclerosis Risk in Communities Study.
Tien Yin Wong,Tien Yin Wong,Ronald Klein,David Couper,Lawton S. Cooper,Eyal Shahar,Larry D. Hubbard,Marion R. Wofford,A. Richey Sharrett +8 more
TL;DR: Most retinal microvascular characteristics were predictive of incident stroke, and the associations were similar for ischaemic strokes specifically, and for strokes in individuals with hypertension, either with or without diabetes.