Ascorbic acid in aromatic hydroxylation. I. A model system for aromatic hydroxylation.
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TLDR
A large number of both normally occurring and foreign compounds of an aromatic nature are hydroxylated in the animal body to yield products with phenolic properties, the pathways by which these products are produced are poorly understood, but several may be postulated.About:
This article is published in Journal of Biological Chemistry.The article was published on 1954-06-01 and is currently open access. It has received 596 citations till now. The article focuses on the topics: Ascorbic acid.read more
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Advances in metal-induced oxidative stress and human disease
Klaudia Jomová,Marian Valko +1 more
TL;DR: An overview of redox and non-redox metal-induced formation of free radicals and the role of oxidative stress in toxic action of metals is provided.
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Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates.
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Tyrosine hydroxylase. the initial step in norepinephrine biosynthesis.
TL;DR: It has now been possible to demonstrate that brain, adrenal medulla, and sympathetically innervated tissues contain a specific hydroxylase that catalyzes the conversion of L-tyrosine to dopa.
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[Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].
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Role of metals in oxygen radical reactions
TL;DR: Factors such as pH and chelation govern the reactivity of the transition metals with dioxygen and "oxy-radicals" and therefore influence the apparent mechanisms by which oxidative damage to phospholipids, DNA, and other biomolecules is initiated.
References
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A new coupling component for sulfanilamide determination
A. Calvin Bratton,E. K. Marshall +1 more
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The estimation of antipyrine in biological materials.
Bernard B. Brodie,Julius Axelrod +1 more
TL;DR: A means of measuring the total water of the body in vivo has been developed and the speed and simplicity of this method recommend it for routine use.
Journal Article
The estimation of acetanilide and its metabolic products, aniline, N-acetyl p-aminophenol and p-amino-phenol, free and total conjugated, in biological fluids and tissues.
Bernard B. Brodie,Julius Axelrod +1 more
TL;DR: A comparison of the solubility characteristics of the authentic compounds and the apparent compounds extracted from the plasma and urine of subjects receiving acetanilide indicates that the methods have a high degree of specificity.
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The determination of diketo l-gulonic acid, dehydro-l-ascorbic acid, and l-ascorbic acid in the same tissue extract by the 2, 4-dinitrophenylhydrazine method.
TL;DR: Methods for determinations of vitamin C dehydro-Z-ascorbic (DHA), DHA, and DKA in the presence of each other are reported, indicating that these derivatives are identical substances.
Journal Article
The fate of antipyrine in man.
Bernard B. Brodie,Julius Axelrod +1 more
TL;DR: The transformation of antipyrine is slow, so that plasma levels after a single therapeutic dose decline only 1 to 12 per cent an hour, resulting in sustained plasma levels for fifteen hours or more, considerably longer than with acetanilide, phenacetin or N-acetyl p-aminophenol.