Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis.
Yadong Song,Xiaoli Liu,Cheng Luo,Liangkai Chen,Lin Gong,Hanbin Yu,Bin Wang,Ernan Liu,Huiqiong Xu,Jiansheng Liang +9 more
Reads0
Chats0
TLDR
In this paper, a meta-analysis was performed to derive a more precise estimation of the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive.Abstract:
Background Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation. Methods PubMed, EMBASE, and Web of Science database searches were conducted to retrieve relevant articles. Results Ultimately, 5,451 CHD cases and 5,561 controls from 15 studies were included. Pooled analysis did not yield any statistically significant association between GSTP1 Ile105Val polymorphism and CHD risk for the overall population (Val vs. Ile: OR, 1.05; 95% CI, 0.93 to 1.18; Val/Val vs. Ile/Ile: OR, 1.09; 95% CI, 0.83 to 1.42; Val/Ile vs. Ile/Ile: OR, 1.09; 95% CI, 0.93 to 1.28; Val/Val vs. Val/Ile+Ile/Ile: OR, 1.04; 95% CI, 0.83 to 1.30; Val/Val+Val/Ile vs. Ile/Ile: OR, 1.14; 95% CI, 0.97 to 1.33). Subgroup analyses and sensitivity analyses indicated that GSTP1 Ile105Val polymorphism was still not associated with an increased risk of CHD. After excluding studies detected by Galbraith plots as major sources of heterogeneity, these relationships were still not significant. Conclusions The overall results did not reveal a major role of the GSTP1 Ile105Val polymorphism in modulating CHD risk. Well-designed studies with large sample sizes are needed to validate our findings and explore the possible gene-gene or gene-environment interactions.read more
Citations
More filters
Book ChapterDOI
Brain Tumor Detection Using Deep Network EfficientNet-B0
TL;DR: In this article , a DL-based modified model which is backed by EfficientNet-B0 was proposed to predict the MRI images as tumorous or non-tumorous, which achieved a detection accuracy of 99.97%, precision of 91.63%, F1-score of 86.94%, and recall score of 85.49% in the proposed model.
Journal ArticleDOI
Research Progress on Risk Factors for Severe Coronary Artery Disease in Young Female Patients
Journal ArticleDOI
Genetic predictors of oxidative stress in the indigenous ethnous of the Arctic
TL;DR: In this article , a molecular genetic study of the genes involved in oxidative stress in 44 representatives of the Nenets ethnic group permanently residing on the Vaygach Island was carried out.
Journal ArticleDOI
Wildfire-related smoke inhalation worsens cardiovascular risk in sleep disrupted rats
W. Kyle Martin,Mette C. Schladweiler,Wendy M. Oshiro,John Albert Smoot,Anna Fisher,William G. Williams,Matthew Valdez,Carley N. Miller,Thomas N. Jackson,Danielle L. Freeborn,David Davies,M. Ian Gilmour,Urmila P. Kodavanti,Prasada Rao S. Kodavanti,Mehdi S. Hazari,Aimen K. Farraj +15 more
TL;DR: In this article , the effects of single or repeated exposure to eucalyptus wood smoke (ES), a key wildland fire air pollution source, on mild sleep loss in the form of gentle handling in rats were evaluated.
References
More filters
Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Operating characteristics of a rank correlation test for publication bias.
TL;DR: In this paper, an adjusted rank correlation test is proposed as a technique for identifying publication bias in a meta-analysis, and its operating characteristics are evaluated via simulations, and the test statistic is a direct statistical analogue of the popular funnel-graph.
Journal ArticleDOI
The pathogenesis of coronary artery disease and the acute coronary syndromes (1).
TL;DR: The two hypotheses to explain the pathogenesis of atherosclerosis, the "incrustation" hypothesis and the "lipid" hypothesis, are now known.
Journal ArticleDOI
Role of oxidative stress in atherosclerosis
TL;DR: Oxidative stress in humans with coronary artery disease is also exacerbated by a reduction of vascular extracellular superoxide dismutase, normally an important protective enzyme against the superoxide anion.
Journal ArticleDOI
Uncertainty in heterogeneity estimates in meta-analyses
TL;DR: It is argued that, although meta-analyses often measure heterogeneity between studies, these estimates can have large uncertainty, which must be taken into account when interpreting evidence.