Association of left ventricular mass with the AGTR1 A1166C polymorphism.
Yu Jin,Tatiana Kuznetsova,Lutgarde Thijs,Boris Schmitz,Yan-Ping Liu,Kei Asayama,Kei Asayama,Stefan-Martin Brand,Stephane Heymans,Eva Brand,Robert Fagard,Jan A. Staessen,Jan A. Staessen +12 more
TLDR
LV mass index is associated with the AGTR1 A1166C polymorphism and further research should clarify to what extent this association might be mediated via different expression ofAGTR1 as modulated by microRNA-155.About:
This article is published in American Journal of Hypertension.The article was published on 2012-04-01 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Angiotensin II.read more
Citations
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Journal Article
Continuous Relation Between Left Ventricular Mass and Cardiovascular Risk in Essential Hypertension
GiuseppeSchillaci,PaoloVerdecchia,CarloPorcellati,OlgaCuccurullo,CarmelaCosco,FrancescoPerticone +5 more
TL;DR: The detection of left ventricular (LV) hypertrophy on echocardiography is a powerful risk indicator in essential hypertension, but the prognostic impact of LV mass values within the “normal” range and the shape of the relation between LV mass and prognosis remain unclear.
Journal Article
MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy
TL;DR: It is proposed that microRNAs play an essential regulatory role in the development of cardiac hypertrophy, wherein downregulation of miR-1 is necessary for the relief of growth-related target genes from its re-expression in a mouse model.
Journal ArticleDOI
Preconditioning protects the heart in a prolonged uremic condition.
Gabriella F. Kocsis,Márta Sárközy,Péter Bencsik,Márton Pipicz,Zoltán Varga,János Pálóczi,Csaba Csonka,Péter Ferdinandy,Tamás Csont +8 more
TL;DR: It is concluded that although prolonged experimental uremia leads to severe metabolic changes and the development of a mild myocardial dysfunction, the cardioprotective effect of ischemic preconditioning is still preserved.
Journal ArticleDOI
MicroRNAs Are Involved in End-Organ Damage During Hypertension
Ward Heggermont,Stephane Heymans +1 more
TL;DR: The involvement of miRs in pathological end-organ remodeling processes and try to demonstrate some common miR signatures in distinct end organs are emphasized to provide proof of arterial hypertension being a systemic disease, similar to diabetes mellitus or metabolic syndrome.
Journal ArticleDOI
Unravelling the Lesser Known Facets of Angiotensin II Type 1 Receptor
TL;DR: Besides other pathways, RAS still remains the main player in blood pressure regulation and AT1R has recently emerged as a molecule with diverse roles ranging from physiologic to cancer progression.
References
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Journal ArticleDOI
Recommendations for quantitation of the left ventricle by two-dimensional echocardiography. American Society of Echocardiography Committee on Standards, Subcommittee on Quantitation of Two-Dimensional Echocardiograms.
Nelson B. Schiller,P. M. Shah,Michael H. Crawford,Anthony N. DeMaria,Richard B. Devereux,Harvey Feigenbaum,H. Gutgesell,Nathaniel Reichek,David J. Sahn,Ingela Schnittger +9 more
TL;DR: It is the opinion that current technology justifies the clinical use of the quantitative two-dimensional methods described in this article and the routine reporting of left ventricular ejection fraction, diastolic volume, mass, and wall motion score.
Journal ArticleDOI
Echocardiographic assessment of left ventricular hypertrophy: Comparison to necropsy findings
Richard B. Devereux,Richard B. Devereux,Daniel R. Alonso,Daniel R. Alonso,Elizabeth M. Lutas,Elizabeth M. Lutas,Geoffrey J. Gottlieb,Geoffrey J. Gottlieb,E Campo,E Campo,Irene Sachs,Irene Sachs,Nathaniel Reichek,Nathaniel Reichek +13 more
TL;DR: To determine the accuracy of echocardiographic left ventricular (LV) dimension and mass measurements for detection and quantification of LV hypertrophy, results of blindly read antemortem e chocardiograms were compared with LV mass measurements made at necropsy in 55 patients.
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American Society of Echocardiography Recommendations for Use of Echocardiography in Clinical Trials A Report from the American Society of Echocardiography's Guidelines and Standards Committee and The Task Force on Echocardiography in Clinical Trials
John S. Gottdiener,James Bednarz,Richard B. Devereux,Julius M. Gardin,Allan L. Klein,Warren J. Manning,Annitta Morehead,Dalane W. Kitzman,Jae Oh,Miguel A. Quinones,Nelson B. Schiller,James H. Stein,Neil J. Weissman +12 more
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microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart
Ning Liu,Svetlana Bezprozvannaya,Andrew H. Williams,Xiaoxia Qi,James A. Richardson,Rhonda Bassel-Duby,Eric N. Olson +6 more
TL;DR: Findings point to these miRNAs as critical components of an SRF-dependent myogenic transcriptional circuit in orchestrating cardiac development, gene expression, and function.
Journal ArticleDOI
MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy
TL;DR: It is proposed that microRNAs play an essential regulatory role in the development of cardiac hypertrophy, wherein downregulation of miR-1 is necessary for the relief of growth-related target genes from its repressive influence and induction ofhypertrophy.