Open Access
Associations of potentially inappropriate medication use with four year survival of an inception cohort of nursing home residents
Kristel Paque,Kristel Paque,Monique Elseviers,Robert Vander Stichele,Tinne Dilles,Koen Pardon,Luc Deliens,Luc Deliens,Thierry Christiaens +8 more
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TLDR
Polypharmacy and PIM use at admission were relatively high in this cohort, although neither was associated with mortality, and residents survived a relatively short time after NH admission.Abstract:
Background Survival in older adults has a high variability. The possible association of length of survival with potentially inappropriate medication (PIM) use remains unclear. Aim To examine the four-year survival rate, the prevalence of polypharmacy and PIM use at admission, and the association between the two, in an inception cohort of newly admitted nursing home residents Methods Data were used from ageing@NH, a prospective observational cohort study in nursing homes. Residents (n = 613) were followed for four years after admission or until death. PIM use was measured at admission, using STOPPFrail. The Kaplan-Meier method was used to estimate survival, using log-rank tests for subgroup analyses. Cox regression analyses was used to explore associations with PIM use and polypharmacy, corrected for covariates Results Mean age was 84, 65% were females. After one, two, three and four years the survival rates were respectively 79%, 60.5%, 47% and 36%. At admission, 47% had polypharmacy and 40% excessive polypharmacy, 11% did not use any PIMs, and respectively 28%, 29%, and 32% used one, two and three or more PIMs. No difference in survival was found between polypharmacy and no polypharmacy, and PIM use and no PIM use at admission. Neither polypharmacy nor PIM use at admission were associated with mortality. Conclusion Residents survived a relatively short time after NH admission. Polypharmacy and PIM use at admission were relatively high in this cohort, although neither was associated with mortality.read more
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Alzheimer's & Dementia: the Journal of the Alzheimer's Association.
TL;DR: Alzheimer’s & Dementia: The Journal of the Alzheimer's Association received acceptance for inclusion n MEDLINE, the bibliographic database of the U.S. National Library of Medicine.
Journal ArticleDOI
Potentially inappropriate medications for the elderly: Incidence and impact on mortality in a cohort ten-year follow-up
Natacha Christina de Araújo,Erika Aparecida Silveira,Brenda Godoi Mota,João Paulo Neves Mota,Ana Elisa Bauer de Camargo Silva,Rafael Alves Guimarães,Valéria Pagotto +6 more
TL;DR: The study highlights the high consumption of PIM among the elderly causing polypharmacy risks and health professionals working in drug treatment need to be alert to polyphARMacy risks to ensure the rational use of medications.
Journal ArticleDOI
Use and Deprescribing of Potentially Inappropriate Medications in Frail Nursing Home Residents.
Anne Fournier,Anne Fournier,Pauline Anrys,Jean-Baptiste Beuscart,Olivia Dalleur,Olivia Dalleur,Séverine Henrard,Veerle Foulon,Anne Spinewine +8 more
TL;DR: A significant and encouraging decrease in PIM prevalence over time was observed among frail NHRs with poor survival prognosis, probably facilitated by medication reviews, and the overall prevalence of PIMs remained high, however.
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The JAPAN-FORTA (Fit fOR The Aged) list: Consensus validation of a clinical tool to improve drug therapy in older adults.
Farhad Pazan,Yana Gercke,Christel Weiss,Martin Wehling,Hiroshi Akazawa,Taro Kojima,Ryota Kumaki,Masahiro Akishita,Yasushi Takeya,Yoshiyuki Ohno,Takashi Yamanaka,Koichi Kozaki,Yusuke Suzuki,Katsuyoshi Mizukami,Fumihiro Mizokami,Yoshiyuki Ikeda,Atsuya Shimizu +16 more
TL;DR: The new JAPAN-FORTA list addresses the appropriateness of drug treatment in older people in Japan by issuing both positive and negative medication recommendations and its country-specific version is now available for Japan.
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Drug interactions for elderly people with mental and behavioral disorders: a systematic scoping review
TL;DR: To consider agomelatine, bupropion, moclobemide and melatonin as potential safer options for benzodiazepines, sleep hygiene; deprescription; medication review; and clinical monitoring of adverse drug reactions are strongly recommended.
References
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Terri R. Fried,Terri R. Fried,John R. O'Leary,Virginia Towle,Mary K. Goldstein,Mary K. Goldstein,Mark Trentalange,Deanna K. Martin +7 more
TL;DR: Evidence regarding the health outcomes associated with polypharmacy, defined as number of prescribed medications, in older community‐dwelling persons, is summarized.