Journal ArticleDOI
Asymmetric fluorination, trifluoromethylation, and perfluoroalkylation reactions.
Jun-An Ma,Dominique Cahard +1 more
About:
This article is published in Chemical Reviews.The article was published on 2004-10-12. It has received 763 citations till now. The article focuses on the topics: Trifluoromethylation.read more
Citations
More filters
Journal ArticleDOI
Fluorine in Pharmaceuticals: Looking Beyond Intuition.
TL;DR: Experimental progress in exploration of the specific influence of carbon-fluorine single bonds on docking interactions is reviewed and complementary analysis based on comprehensive searches in the Cambridge Structural Database and the Protein Data Bank is added.
Journal ArticleDOI
Introduction of Fluorine and Fluorine-Containing Functional Groups
TL;DR: This Review gives a brief summary of conventional fluorination reactions, including those reactions that introduce fluorinated functional groups, and focuses on modern developments in the field.
Journal ArticleDOI
Catalysis for fluorination and trifluoromethylation
TL;DR: Reactions to make organofluorides that have emerged within the past few years are discussed and which exemplify how to overcome some of the intricate challenges associated with fluorination.
Journal ArticleDOI
Aromatic Trifluoromethylation with Metal Complexes
TL;DR: Molecules bearing a trifluoromethyl group constitute one of the most important classes of selectively fluorinated compounds, and derivatives bearing the CF3 group on aromatic rings are particularly numerous and important.
References
More filters
Journal ArticleDOI
Fluorine substituent effects (on bioactivity)
TL;DR: The influence of fluorination on acidity, hydrogen-bonding, and lipophilicity that affect compound absorption and distribution is discussed in this paper, and the current perspectives on fluorine steric interactions and the controversial role of hydrogen bonding involving the CF bond are discussed.
Journal ArticleDOI
Perfluoroalkylation with Organosilicon Reagents
Journal ArticleDOI
Organic Fluorine Hardly Ever Accepts Hydrogen Bonds
Jack D. Dunitz,Robin Taylor +1 more
TL;DR: This article showed that covalently bound fluorine hardly ever acts as a hydrogen-bond acceptor, which is in accord with results of other physicochemical studies and with the physical properties of fluorinated organic compounds.