B-Type Natriuretic Peptides and High-Sensitive Troponin I as COVID-19 Survival Factors: Which One Is the Best Performer?
Renato de Falco,Maria Vargas,Daniela De Palma,Marcella Savoia,Anna Miscioscia,Biagio Pinchera,Martina Vano,Giuseppe Servillo,Ivan Gentile,Giuliana Fortunato +9 more
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TLDR
In this paper, the authors evaluated which of these common markers of cardiac disease is the most useful predictor of fatal outcome in COVID-19 patients, and found that NT-proBNP proved to be the best prognostic tool for fatal outcome.Abstract:
Increased concentrations of B-type natriuretic peptide (BNP), N-terminal pro-B-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin I (HsTnI) in COVID-19 patients have already been reported. The aim of this study is to evaluate which of these common markers of cardiac disease is the most useful predictor of fatal outcome in COVID-19 patients. One hundred and seventy-four patients affected with COVID-19 were recruited, and markers of cardiac disease and the clinical history of the patients were collected at admission in the infectious disease unit or intensive care unit. NT-proBNP, BNP and HsTnI values were higher in in-hospital non-surviving patients. Receiver operating characteristic (ROC) curve analysis of NT-proBNP, BNP and HsTnI was performed, with NT-proBNP (AUC = 0.951) and HsTnI (AUC = 0.947) being better performers (p = 0.01) than BNP (AUC = 0.777). Logistic regression was performed assessing the relation of HsTnI and NT-proBNP to fatal outcome adjusting for age and gender, with only NT-proBNP being significant. The population was then divided into two groups, one with higher NT-proBNP values at admission than the cut-off resulted from the ROC curve (511 ng/L) and a second one with lower values. The Kaplan–Meier analysis showed an absence of fatal outcome in the group of patients with NT-proBNP values lower than the cut-off (p < 0.001). NT-proBNP proved to be the best prognostic tool for fatal outcome among markers of cardiac disease in COVID-19 patients.read more
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A Real Pandora’s Box in Pandemic Times: A Narrative Review on the Acute Cardiac Injury Due to COVID-19
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TL;DR: In patients with Coronavirus disease 2019, COVID-19, a significant increase in serum levels of cardiac troponin or other various biomarkers was observed, suggesting acute cardiac injury, thus predicting both a severe course of the disease and a poor outcome.
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References
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Journal ArticleDOI
Elevated N-terminal pro-brain natriuretic peptide is associated with increased mortality in patients with COVID-19: systematic review and meta-analysis.
TL;DR: Elevated NT-proBNP level was associated with increased mortality in COVID-19 pneumonia and summary receiver operating characteristic curve analysis demonstrates an area under curve of 0.90.
Journal ArticleDOI
BNP in septic patients without systolic myocardial dysfunction
Renana Shor,Yoseph Rozenman,Aharon Bolshinsky,David Harpaz,Yulian Tilis,Zipora Matas,Asora Fux,Mona Boaz,Aaron Halabe +8 more
TL;DR: BNP is positively correlated with CRP levels in septic patients without clinical or echocardiographic evidence of systolic dysfunction and no association was found between death and BNP values.
Journal ArticleDOI
The effect of glycosylation on plasma N-terminal proBNP-76 levels in patients with heart or renal failure
Toshio Nishikimi,Masashi Ikeda,Yosuke Takeda,Toshihiko Ishimitsu,Ikuko Shibasaki,Hirotsugu Fukuda,Hideyuki Kinoshita,Yasuaki Nakagawa,Koichiro Kuwahara,Kazuwa Nakao +9 more
TL;DR: The findings suggest that most endogenous plasma NT-BNP is glycosylated and therefore undetectable with the current assay system, and that the relative Glycosylation level is increased by haemodialysis.
Journal ArticleDOI
Influence of Glycosylation on Diagnostic and Prognostic Accuracy of N-Terminal Pro–B-Type Natriuretic Peptide in Acute Dyspnea: Data from the Akershus Cardiac Examination 2 Study
Helge Røsjø,Mai Britt Dahl,Marit Jørgensen,Ragnhild Røysland,Jon Brynildsen,Alessandro Cataliotti,Geir Christensen,Arne Didrik Høiseth,Tor-Arne Hagve,Torbjørn Omland +9 more
TL;DR: NT-proBNP concentrations were higher, and diagnostic and prognostic accuracy was improved, by pretreating tubes with deglycosylation enzymes, as assessed by the net reclassification index.
Journal ArticleDOI
Cardiovascular biomarkers in patients with COVID-19.
Christian Mueller,Evangelos Giannitsis,Allan S. Jaffe,Kurt Huber,Johannes Mair,Louise Cullen,Ola Hammarsten,Nicholas L. Mills,Martin Möckel,Konstantin A. Krychtiuk,Kristian Thygesen,Bertil Lindahl +11 more
TL;DR: Interpretation of cardiac troponin and natriuretic peptide concentrations as quantitative variables may aid in risk stratification in COVID-19/pneumonia and also will ensure that these biomarkers maintain high diagnostic accuracy for AMI and AHF.
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