Journal ArticleDOI
beta-Endorphin is not detectable in plasma from normal human subjects.
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TLDR
Highly purified, natural beta-lipotropin is not peripherally converted to beta- endorphin in vivo in normal subjects, and significant amounts of beta-endorphin are present in plasma of patients with endocrine disorders associated with increased ACTH and beta- Lipotropin production.Abstract:
beta-Endorphin is not detectable in plasma from normal human subjects when measured under baseline conditions or after the subjects have received vasopressin, an agent that elevates beta-lipotropin and adrenocorticotropic hormone (ACTH). Significant amounts of beta-endorphin are present in plasma of patients with endocrine disorders associated with increased ACTH and beta-lipotropin production. Highly purified, natural beta-lipotropin is not peripherally converted to beta-endorphin in vivo in normal subjects.read more
Citations
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Journal ArticleDOI
Specific nonopiate receptors for beta-endorphin
TL;DR: Iodinated beta H-[2-D-alanine]endorphin exhibits specific binding to cultured human lymphocytes, which suggests the existence of a specific, non-opiate binding site (receptor) for beta- endorphin.
Journal ArticleDOI
The endocrinology of the opiates and opioid peptides
John E. Morley,John E. Morley +1 more
TL;DR: This review deals with the interactions of opiates with the endocrine system in rat and man and suggests a possible local neuromodulatory role for the opioid peptides in the control of carbohydrate metabolism and reproductive processes.
Journal ArticleDOI
Depressed mood and other psychiatric manifestations of Cushing's syndrome: relationship to hormone levels.
TL;DR: A statistically significant relationship was found between the overall psychiatric disability rating and cortisol and ACTH level and low ACTH levels were significantly associated with milder rather than pronounced depressed mood.
Journal ArticleDOI
Neuropsychiatric manifestations of patients with Cushing's syndrome. Relationship to cortisol and adrenocorticotropic hormone levels.
TL;DR: A statistically significant relationship was found between the overall neuropsychiatric disability rating and cortisol and adrenocorticotropic hormone (ACTH) levels.
Journal ArticleDOI
β-ENDORPHIN IN THE HUMAN PANCREAS
TL;DR: Using a specific antiserum, β-endorphin was quantitated in 8 human pancreas obtained at autopsy by radioimmunoassay and localized by immunocytochemistry, suggesting that β- endorphin may participate in intraislet regulation of pancreatic hormone secretion.
References
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Journal ArticleDOI
beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland
Roger Guillemin,Therese Vargo,Jean Rossier,Scott Minick,Nicholas Ling,Catherine Rivier,Wylie Vale,Floyd E. Bloom +7 more
TL;DR: Both hormones possess common and identical regulatory mechanisms and there may be a functional role for circulating beta-endorphin in response to acute stress or long-term adrenalectomy.
Journal ArticleDOI
Common precursor to corticotropins and endorphins
TL;DR: Double-antibody immunoprecipitation procedures with antisera to endorphins and to corticotropin (ACTH) were used to study the biosynthesis of these peptides in a mouse pituitary tumor cell line to identify a tryptic peptide that contains the opiate-active methionine-enkephalin sequence.
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Endorphins: profound behavioral effects in rats suggest new etiological factors in mental illness.
TL;DR: The endogenous morphinomimetic brain peptides Met5-enkephalin and alpha-, beta-, and gamma-endorphins have been evaluated in rats after intracerebrospinal fluid injection and their potent and divergent responses to naturally occurring subtances suggest that alterations in their homeostatic regulation could have etiological significance in mental illness.
Journal ArticleDOI
The C-fragment of beta-lipotropin: an endogenous neuroleptic or antipsychotogen?
Yasuko F. Jacquet,Neville Marks +1 more
TL;DR: The similarity of this behavior to that seen after systemic administration to experimental animals of exogenous neuroleptics suggests that a disturbance in the bioavailability of this neuropeptide to receptor sites in brain-perhaps due to lack of enzymatic cleavage from the circulating parent hormone, beta-lipotropin--may be an etiological factor in those psychopathological states for which the exogenous neuroscience exert an ameliorative influence.
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Characterization of a common precursor to corticotropin and beta-lipotropin: identification of beta-lipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system.
James L. Roberts,Edward Herbert +1 more
TL;DR: Radioactive proteins synthesized in an mRNA-dependent reticulocyte cell-free system under the direction of mRNA from AtT-20/D-16v mouse cells were isolated by specific immunoprecipitation using antiserum to either alpha(1-24) corticotropin or beta-endorphin [beta(61-91) lipotropin].