Journal ArticleDOI
Beta3-adrenoceptors in the cardiovascular system.
TLDR
The pharmacological and molecular evidence that supports the functional role of beta3-adrenoceptors in cardiovasculartissues of various species, including humans, will be discussed and might provide new insights into the understanding of the abnormal responsiveness of the cardiovascular system to catecholamines in heart failure and its treatment with beta2- adrenoceptor antagonists.About:
This article is published in Trends in Pharmacological Sciences.The article was published on 2000-11-01. It has received 185 citations till now. The article focuses on the topics: Contractility & Vascular smooth muscle.read more
Citations
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Journal ArticleDOI
What Is the Role of β-Adrenergic Signaling in Heart Failure?
TL;DR: Clinically, &bgr;-adrenergic antagonists represent the most important advance in heart failure therapy, but it is still debated whether they act by blocking or by resensitizing the &b gr;- adrenergic receptor system.
Journal Article
Vascular Adrenoceptors: An Update
Serafim Guimarães,D. Moura +1 more
TL;DR: The increased knowledge on the involvement of vascular adrenoceptors in many diseases like Raynaud's, scleroderma, several neurological degenerative diseases (familial amyloidotic polyneuropathy, Parkinson disease, multiple-system atrophy), some kinds of hypertension, etc., will contribute to new and better therapeutic approaches.
Journal ArticleDOI
Nitric oxide and cardiac function: ten years after, and continuing.
TL;DR: Future therapeutic manipulations of cardiac NO synthesis will necessarily draw on additional characterization of the cellular and molecular determinants for the net effect of this versatile radical on the cardiomyocyte biology.
Journal ArticleDOI
The Role of the Autonomic Nervous System in Sudden Cardiac Death
TL;DR: The anatomy of both systems, the sympathetic and the parasympathetic systems, are described, which are complex and susceptible to control at several levels, from centrally mediated baroreceptors and chemoreceptors to local interneuronal interactions.
Journal ArticleDOI
Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium
Stéphane Moniotte,Lester Kobzik,Olivier Feron,Jean-Noël Trochu,Chantal Gauthier,Jean-Luc Balligand +5 more
TL;DR: Opposite changes occur in &bgr;1- and &bGr;3-adrenoceptor abundance in the failing left ventricle, with an imbalance between their inotropic influences that may underlie the functional degradation of the human failing heart.
References
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Journal ArticleDOI
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA.
John R. Riordan,Johanna M. Rommens,Batsheva Kerem,Noa Alon,Richard Rozmahel,Zbyszko Grzelczak,Julian Zielenski,Si Lok,Natasa Plavsic,Jia Ling Chou,Mitchell L. Drumm,Michael C. Iannuzzi,Francis S. Collins,Lap-Chee Tsui +13 more
TL;DR: A deletion of three base pairs that results in the omission of a phenylalanine residue at the center of the first predicted nucleotide-binding domain was detected in CF patients.
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Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.
TL;DR: A mechanism previously shown to mediate uncoupling of the β2-adrenergic receptor from Gs and thus heterologous desensitization (PKA-mediated receptor phosphorylation), also serves to ‘switch’ coupling of this receptor fromGs to Gi and initiate a new set of signalling events.
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β-Adrenergic Receptor Blockade in Chronic Heart Failure
TL;DR: This review describes how a treatment that began as a contraindication became an established treatment of chronic heart failure with β-adrenergic blocking agents.
Journal ArticleDOI
Microbubbles Targeted to Intercellular Adhesion Molecule-1 Bind to Activated Coronary Artery Endothelial Cells
Flordeliza S. Villanueva,Ron J. Jankowski,Sasha Klibanov,Maris L. Pina,Sean Alber,Simon C. Watkins,Gary H. Brandenburger,William R. Wagner +7 more
TL;DR: A gas-filled microbubble with anti-ICAM-1 antibody on its shell specifically binds to activated ECs overexpressing ICam-1.
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Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.
TL;DR: It is concluded that overexpression of beta1-adrenergic receptors in the heart may lead to a short-lived improvement of cardiac function, but that increasedbeta1- adrenergic receptor signalling is ultimately detrimental.