Bilateral simultaneous anterior ischemic optic neuropathy associated with sildenafil
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TLDR
A 55-year-old man with an unremarkable medical history presented simultaneous bilateral NAION 8 months after continuous use of sildenafil 4–5 times a month, the first reported case of simultaneous bilateral nonarteritic anterior ischemic optic neuropathy (NAION) due to sildinafil use.Abstract:
We report a case of simultaneous bilateral nonarteritic anterior ischemic optic neuropathy (NAION) due to sildenafil use. A 55-year-old man with an unremarkable medical history presented simultaneous bilateral NAION 8 months after continuous use of sildenafil 4-5 times a month. At presentation, visual acuity (VA) was 0.7 in the right eye (RE) and 0.9 in the left eye (LE). The visual field showed an inferior altitudinal defect in both eyes and a fundus examination revealed prominent optic disc edema in the RE and a crowded optic disc in the LE. The patient was counseled to discontinue sildenafil, and 3 weeks later VA was 1.0 in both eyes and the optic disc edema in the RE was resolved. However, a visual field defect remained in the RE. Three months later, visual fields were unchanged. To the best of our knowledge, this is the first reported case of simultaneous bilateral NAION due to sildenafil use.read more
Citations
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Journal ArticleDOI
Acute Nonarteritic Anterior Ischemic Optic Neuropathy and Exposure to Phosphodiesterase Type 5 Inhibitors
Ulka B. Campbell,Alexander M. Walker,Michael Gaffney,Kenneth R. Petronis,Dana Creanga,Sheila Quinn,Barbara E.K. Klein,Alan M. Laties,Michael A Lewis,Ira D. Sharlip,Francesca Kolitsopoulos,Brian Klee,Jingping Mo,Robert F. Reynolds +13 more
TL;DR: An approximately twofold increased risk of acute NAION within five half-lives of PDE5i use compared with use in a more prior time period is found.
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Pathophysiology of visual disorders induced by phosphodiesterase inhibitors in the treatment of erectile dysfunction.
Marilita M Moschos,Eirini Nitoda +1 more
TL;DR: The most common phosphodiesterase (PDE) inhibitors used for the treatment of erectile dysfunction and the subsequent visual disorders do not seem to cause permanent toxic effects on chorioretinal tissue and photoreceptors.
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Bilateral Simultaneous Nonarteritic Anterior Ischemic Optic Neuropathy after Ingestion of Sildenafil for Erectile Dysfunction
TL;DR: This is the first reported case of simultaneous bilateral NAION occurred in a diabetic patient early after Sildenafil intake, and patients with predisposing conditions such as diabetes have to be warned against the use of PDE inhibitors.
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Poppers Maculopathy: Complete Restitution of Macular Changes in OCT after Drug Abstinence
TL;DR: Toxic maculopathy due to the consumption of poppers is an important differential diagnosis in acute visual loss without clinico-morphological correlate and optical coherence tomography is the only reliable diagnostic tool in these cases.
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The Relationship Between Phosphodiesterase-5 Inhibitors and Nonarteritic Anterior Ischemic Optic Neuropathy.
TL;DR: Patients with a known history of previous NAION should be cautioned regarding the use of PDE5I for erectile dysfunction or pulmonary hypertension because of the potential increased risk of fellow eye involvement.
References
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Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes
TL;DR: The data support the proposal that enhancement of penile erection by sildenafil in patients with erectile dysfunction involves potentiation of the NO-stimulated cGMP signal mediating relaxation of cavernosal smooth muscle during sexual stimulation.
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Overall cardiovascular profile of sildenafil citrate.
TL;DR: Overall treatment with sildenafil for up to 1 year is well tolerated and is associated with a low incidence of adverse events that result in discontinuation of treatment in <3% of patients, which is generally consistent with the experience observed during clinical development.
Journal ArticleDOI
Sildenafil-associated nonarteritic anterior ischemic optic neuropathy.
TL;DR: A small cup-to-disc ratio may be a risk factor for development of NAION in association with the use of sildenafil.
Journal ArticleDOI
Anterior Ischemic Optic Neuropathy Associated With Viagra
TL;DR: Physicians should counsel patients with crowded optic discs and a history of nonarteritic anterior ischemic optic neuropathy in one eye that use of sildenafil citrate might increase their risk of isChemic optic Neuropathy in the fellow eye.