Journal ArticleDOI
Bilateral subthalamic nucleus deep brain stimulation for advanced PD: correlation of intraoperative MER and postoperative MRI with neuropathological findings.
George J. Counelis,Tanya Simuni,Mark S. Forman,Jurg L. Jaggi,John Q. Trojanowski,Gordon H. Baltuch +5 more
TLDR
This postmortem study correlated intraoperative subthalamic nucleus (STN) deep brain stimulation (DBS) placement and postoperative magnetic resonance imaging (MRI) with autopsy findings in a patient who died suddenly 4 days postoperatively from a pulmonary embolism.Abstract:
This postmortem study correlated intraoperative subthalamic nucleus (STN) deep brain stimulation (DBS) placement and postoperative magnetic resonance imaging (MRI) with autopsy findings in a patient who died suddenly 4 days postoperatively from a pulmonary embolism. The study demonstrates that (1) MRI stereotactic localization combined with microelectrode recording (MER) is an accurate way to target STN; (2) multiple MER tracts do not cause significant injury to the brain; and (3) postoperative MRI accurately demonstrates location of the DBS electrodes.read more
Citations
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Journal ArticleDOI
Deep brain stimulation: postoperative issues.
Günther Deuschl,Jan Herzog,Galit Kleiner-Fisman,Cynthia S. Kubu,Andres M. Lozano,Kelly E. Lyons,Maria C. Rodriguez-Oroz,Filippo Tamma,Alexander I. Tröster,Jerrold L. Vitek,Jens Volkmann,Valerie Voon +11 more
TL;DR: Answer to a series of questions developed to address all aspects of DBS postoperative management and decision‐making with a systematic overview of the literature are outlined.
Journal ArticleDOI
Time-course of nigrostriatal neurodegeneration and neuroinflammation in the 6-hydroxydopamine-induced axonal and terminal lesion models of Parkinson's disease in the rat.
TL;DR: The temporal relationship between neurodegeneration and neuroinflammation in models of Parkinson's disease is highlighted, and should facilitate use of these models in the development of anti-inflammatory therapies for the human condition.
Journal ArticleDOI
Improvement in a quantitative measure of bradykinesia after microelectrode recording in patients with Parkinson's disease during deep brain stimulation surgery
TL;DR: It is demonstrated that there is a significant improvement in upper extremity bradykinesia just after microelectrode recording (MER) before inserting or activating the DBS electrode in patients with Parkinson's disease who undergo STN DBS.
Journal ArticleDOI
Tinnitus modulation by deep brain stimulation in locus of caudate neurons (area LC)
S.W. Cheung,Paul S. Larson +1 more
TL;DR: It is shown that application of deep brain stimulation (DBS) therapy to a locus of caudate neurons (area LC) in the body of the nucleus, a subsite of the striatum that is not part of the classical auditory pathway, can decrease or increase tinnitus loudness perception.
Journal ArticleDOI
Long-term recordings of local field potentials from implanted deep brain stimulation electrodes.
TL;DR: Results support the feasibility of constructing a closed-loop, patient-responsive DBS device based on LFP activity years after DBS implantation and demonstrates a similar profile in response to movement as during acute recordings, although amplitude may decrease.
References
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Journal ArticleDOI
Electrical Stimulation of the Subthalamic Nucleus in Advanced Parkinson's Disease
Patricia Limousin,Paul Krack,Pierre Pollak,Abdelhamid Benazzouz,Claire Ardouin,Dominique Hoffmann,Alim-Louis Benabid +6 more
TL;DR: Electrical stimulation of the subthalamic nucleus is an effective treatment for advanced Parkinson's disease and the severity of symptoms off medication decreases, and the dose of levodopa can be reduced with consequent reduction in dyskinesias.
Journal ArticleDOI
Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's disease.
TL;DR: Bilateral stimulation of the subthalamic nucleus or pars interna of the globus pallidus is associated with significant improvement in motor function in patients with Parkinson's disease whose condition cannot be further improved with medical therapy.
Journal ArticleDOI
Bilateral subthalamic stimulation for Parkinson's disease by using three-dimensional stereotactic magnetic resonance imaging and electrophysiological guidance
Boulos-Paul Bejjani,Didier Dormont,Bernard Pidoux,Jérôme Yelnik,Philippe Damier,Isabelle Arnulf,Anne-Marie Bonnet,Claude Marsault,Yves Agid,Jacques Philippon,Philippe Cornu +10 more
TL;DR: Continuous high-frequency stimulation of the STN applied through electrodes implanted with the aid of 3D MR imaging and electrophysiological guidance is a safe and effective therapy for patients suffering from severe, advanced levodopa-responsive PD.
Journal ArticleDOI
No tissue damage by chronic deep brain stimulation in Parkinson's disease.
Christine Haberler,François Alesch,Peter R. Mazal,Peter Pilz,Kurt A. Jellinger,Michaela M. Pinter,Johannes A. Hainfellner,Herbert Budka +7 more
TL;DR: It is concluded that chronic DBS does not cause damage to adjacent brain tissue and all brains showed well‐preserved neural parenchyma and only mild gliosis around the lead track compatible with reactive changes due to surgical placement of the electrode.
Journal ArticleDOI
Intraoperative microrecordings of the subthalamic nucleus in Parkinson's disease.
TL;DR: In conclusion, microelectrode recording of the subthalamic area improves the accuracy of targeting the STN, indicating a more cell‐sparse nucleus.