J
Johannes A. Hainfellner
Researcher at University of Vienna
Publications - 103
Citations - 5678
Johannes A. Hainfellner is an academic researcher from University of Vienna. The author has contributed to research in topics: Glioma & Neuropathology. The author has an hindex of 37, co-authored 103 publications receiving 5104 citations.
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Journal ArticleDOI
Stem Cell–Related “Self-Renewal” Signature and High Epidermal Growth Factor Receptor Expression Associated With Resistance to Concomitant Chemoradiotherapy in Glioblastoma
Anastasia Murat,Eugenia Migliavacca,Thierry Gorlia,Wanyu L. Lambiv,Tal Shay,Marie-France Hamou,Nicolas de Tribolet,Luca Regli,Wolfgang Wick,Mathilde C.M. Kouwenhoven,Johannes A. Hainfellner,Frank L. Heppner,Pierre-Yves Dietrich,Yitzhak Zimmer,J. Gregory Cairncross,Robert-Charles Janzer,Eytan Domany,Mauro Delorenzi,Roger Stupp,Monika E. Hegi +19 more
TL;DR: This study provides first clinical evidence for the implication of a "glioma stem cell" or "self-renewal" phenotype in treatment resistance of glioblastoma.
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Mice with Combined Gene Knock-Outs Reveal Essential and Partially Redundant Functions of Amyloid Precursor Protein Family Members
Sabine Heber,Jochen Herms,Vladan Gajic,Johannes A. Hainfellner,Adriano Aguzzi,Thomas Rülicke,Hans A. Kretzschmar,Cornelia von Koch,Sangram S. Sisodia,Phillippe Tremml,Hans-Peter Lipp,David P. Wolfer,Ulrike Müller,Ulrike Müller +13 more
TL;DR: The phenotypes of mice lacking individual or all possible combinations of APP family members are examined and genetic evidence for at least some distinct physiological roles of APP and APLP2 is provided by demonstrating that combinations of single knock-outs with the APLP1 mutation resulted in double mutants of clearly different phenotypes.
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Delta-like 4 Notch Ligand Regulates Tumor Angiogenesis, Improves Tumor Vascular Function, and Promotes Tumor Growth In vivo
Ji-Liang Li,Richard C.A. Sainson,Wen Shi,Russell Leek,Laura S. Harrington,Matthias Preusser,Swethajit Biswas,Helen Turley,Emily Heikamp,Johannes A. Hainfellner,Adrian L. Harris +10 more
TL;DR: It is shown that DLL4, when expressed in tumor cells, functions as a negative regulator of tumor angiogenesis by reducing the number of blood vessels in all five types of xenografts, but acts as a positive driver for tumor growth in two of them (human glioblastoma and prostate cancer).
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No tissue damage by chronic deep brain stimulation in Parkinson's disease.
Christine Haberler,François Alesch,Peter R. Mazal,Peter Pilz,Kurt A. Jellinger,Michaela M. Pinter,Johannes A. Hainfellner,Herbert Budka +7 more
TL;DR: It is concluded that chronic DBS does not cause damage to adjacent brain tissue and all brains showed well‐preserved neural parenchyma and only mild gliosis around the lead track compatible with reactive changes due to surgical placement of the electrode.
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Mutations of the prion protein gene phenotypic spectrum
Gabor G. Kovacs,Gianriccardo Trabattoni,Johannes A. Hainfellner,James W. Ironside,Richard Knight,Herbert Budka +5 more
TL;DR: A systematic analysis of over 500 case reports of patients with PRNP abnormalities compares clinical, neuropathological and molecular data in five groups, namely GSS, FFI, fCJD, base pair insertion (BPI), and all cases collectively.