Journal ArticleDOI
Bilateral symmetry and coherence of subthalamic nuclei beta band activity in Parkinson's disease.
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TLDR
It is demonstrated for the first time that the beta band oscillations recorded in the local field potential of the subthalamic nuclei (STN), while appearing different across subjects, are occurring at the same frequencies bilaterally and are coherent between the two STNs of individual PD subjects.About:
This article is published in Experimental Neurology.The article was published on 2010-01-01. It has received 89 citations till now. The article focuses on the topics: Subthalamic nucleus & Basal ganglia.read more
Citations
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Journal ArticleDOI
Closed-Loop Deep Brain Stimulation Is Superior in Ameliorating Parkinsonism
Boris Rosin,Maya Slovik,Rea Mitelman,Rea Mitelman,Michal Rivlin-Etzion,Michal Rivlin-Etzion,Suzanne N. Haber,Zvi Israel,Eilon Vaadia,Eilon Vaadia,Hagai Bergman,Hagai Bergman +11 more
TL;DR: Closed-loop DBS paradigms, by modulating pathological oscillatory activity rather than the discharge rate of the BG-cortical networks, may afford more effective management of advanced PD.
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Oscillations and the basal ganglia: motor control and beyond.
John-Stuart Brittain,Peter Brown +1 more
TL;DR: The neural underpinnings of oscillations in the basal ganglia are explored, including the important balance to be struck between facilitating information transmission and limiting information coding capacity, and the notion that synchronised oscillatory activity can be broadly categorised as immutability promoting rhythms that reinforce incumbent processes, and mutability promotes rhythms that favour novel processing.
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Bilateral adaptive deep brain stimulation is effective in Parkinson's disease
Simon Little,Martijn Beudel,Ludvic Zrinzo,Thomas Foltynie,Patricia Limousin,Marwan Hariz,Spencer Neal,Binith Cheeran,Hayriye Cagnan,James Gratwicke,Tipu Z. Aziz,Tipu Z. Aziz,A Pogosyan,Peter Brown +13 more
TL;DR: Bilateral aDBS can improve both axial and limb symptoms and can track the need for stimulation across drug states and in the face of concurrent medication.
Journal ArticleDOI
Beta burst dynamics in Parkinson's disease OFF and ON dopaminergic medication.
Gerd Tinkhauser,Alek Pogosyan,Alek Pogosyan,Huiling Tan,Huiling Tan,Damian M. Herz,Damian M. Herz,Andrea A. Kühn,Peter Brown,Peter Brown +9 more
TL;DR: It is demonstrated that long duration beta bursts are associated with an increase in local and interhemispheric synchronization, which may compromise information coding capacity and thereby motor processing.
Journal ArticleDOI
What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease?
Simon Little,Peter Brown +1 more
TL;DR: In this article, the timing and intensity of DBS stimulation are titrated according to biomarkers that capture current clinical state, such as bradykinesia and rigidity across patients.
References
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Journal ArticleDOI
Pathological synchronization in Parkinson's disease: networks, models and treatments
TL;DR: This review is based on presentations at the annual INMED/TINS symposium, Physiogenic and pathogenic oscillations: the beauty and the beast, based on work using tissue slice preparations, animal models and in humans with Parkinson's disease.
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A framework for the analysis of mixed time series/point process data--theory and application to the study of physiological tremor, single motor unit discharges and electromyograms.
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Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
TL;DR: Local potentials from the globus pallidus interna and subthalamic nucleus are recorded in four awake patients after neurosurgery for Parkinson's disease to demonstrate synchronization of activity does occur between pallidum and STN, and its pattern is critically dependent on the level of dopaminergic activity.
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Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease
TL;DR: It is argued that the balance between these modes determines the effects of basal ganglia‐thalamocortical projections on the motor areas of the cortex, and that synchronisation at high frequency restores dynamic task‐related cortical ensemble activity in the gamma band.
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Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease.
TL;DR: A link between levodopa‐induced improvements in bradykinesia and rigidity and reductions in population synchrony at frequencies < 35 Hz in the region of the STN in patients with PD is supported.