Journal ArticleDOI
Biliary tract cancers
Piet C. de Groen,Gregory J. Gores,Nicholas F. LaRusso,Leonard L. Gunderson,David M. Nagorney +4 more
TLDR
In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually as mentioned in this paper, which is the second most common primary hepatobiliary cancer after hepatocellular cancer.Abstract:
In the United States, an estimated 20,000 new cases of liver and biliary tract cancer are diagnosed annually.1 Biliary tract cancer is the second most common primary hepatobiliary cancer, after hepatocellular cancer. Approximately 7500 new cases of biliary tract cancer are diagnosed per year; about 5000 of these are gallbladder cancer, and between 2000 and 3000 are bile-duct cancers.1 Biliary tract cancers have traditionally been divided into cancers of the gallbladder, the extrahepatic bile ducts, and the ampulla of Vater, whereas intrahepatic bile-duct cancers have been classified as primary liver cancers.2 The term “cholangiocarcinoma” was originally intended to refer only . . .read more
Citations
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Journal ArticleDOI
A model to predict survival in patients with end‐stage liver disease
Patrick S. Kamath,Russell H. Wiesner,Michael Malinchoc,Walter K. Kremers,Terry M. Therneau,Catherine L. Kosberg,Gennaro D'Amico,E. Rolland Dickson,M.B.A. W. Ray Kim M.D. +8 more
TL;DR: The MELD scale is a reliable measure of mortality risk in patients with end‐stage liver disease and suitable for use as a disease severity index to determine organ allocation priorities in patient groups with a broader range of disease severity and etiology.
Journal ArticleDOI
Increasing incidence and mortality of primary intrahepatic cholangiocarcinoma in the United States.
TL;DR: There has been a marked increase in the incidence and mortality from intrahepatic cholangiocarcinoma in the United States in recent years, and this tumor continues to be associated with a poor prognosis.
Journal ArticleDOI
Preoperative Biliary Drainage for Cancer of the Head of the Pancreas
Niels A. van der Gaag,Erik A.J. Rauws,Casper H.J. van Eijck,Marco J. Bruno,Erwin van der Harst,Frank J G M Kubben,Josephus J. G. M. Gerritsen,Jan Greve,Michael F. Gerhards,Ignace H J T de Hingh,Jean H. G. Klinkenbijl,Chung Y. Nio,Steve M. M. de Castro,Olivier R. Busch,Thomas M. van Gulik,Patrick M.M. Bossuyt,Dirk J. Gouma +16 more
TL;DR: Routine preoperative biliary drainage in patients undergoing surgery for cancer of the pancreatic head increases the rate of complications.
Journal ArticleDOI
Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment†
Boris Blechacz,Gregory J. Gores +1 more
TL;DR: In the last several years there have been significant new insights into the molecular pathogenesis of CCA, and new diagnostic and therapeutic modalities have also been developed, resulting in improved detection rates and outcomes.
Journal ArticleDOI
Guidelines for the diagnosis and treatment of cholangiocarcinoma: consensus document
Shahid A. Khan,Brian R. Davidson,Robert D. Goldin,Stephen P. Pereira,William Rosenberg,Simon D. Taylor-Robinson,Andrew V. Thillainayagam,H.C. Thomas,Mark Thursz,Harpreet Wasan +9 more
TL;DR: These guidelines are intended to bring consistency and improvement in the patient’s management from first suspicion of cholangiocarcinoma through to confirmation of the diagnosis and subsequent management, and are subject to change in light of future advances in scientific knowledge.
References
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Cancer statistics, 1998
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Journal ArticleDOI
Endosonography-guided fine-needle aspiration biopsy: Diagnostic accuracy and complication assessment
TL;DR: EUS-FNA accurately and safely evaluates solid peri-intestinal lesions and improves lymph node staging accuracy and specificity and accuracy in patients with previously failed biopsy procedures.
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Cholangiocarcinoma. A spectrum of intrahepatic, perihilar, and distal tumors.
Attila Nakeeb,Henry A. Pitt,Taylor A. Sohn,Jo Ann Coleman,Ross A. Abrams,Steven Piantadosi,Ralph H. Hruban,Keith D. Lillemoe,Charles J. Yeo,John L. Cameron +9 more
TL;DR: Cholangiocarcinoma is best classified into three broad groups: 1) intrahepatic, 2) perihilar, and 3) distal tumors, which correlate with anatomic distribution and imply preferred treatment.
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Natural history and prognostic factors in 305 Swedish patients with primary sclerosing cholangitis.
Ulrika Broomé,R Olsson,Lars Lööf,G Bodemar,Rolf Hultcrantz,Åke Danielsson,Hanne Prytz,Hanna Sandberg-Gertzén,S Wallerstedt,Greger Lindberg +9 more
TL;DR: It was found that age, serum bilirubin concentration, and histological stage at the time of diagnosis were independent predictors of a bad prognosis, which should be of value for the timing of transplantation and patient counselling in PSC.
Journal ArticleDOI
Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis. an unusual tumor with distinctive clinical and pathological features.
TL;DR: The distinctive clinical and pathological features of adenocarcinomas of the hepatic duct at its bifurcation within the porta hepatis are described and palliative surgery aimed at relieving biliary obstruction may restore the patient to a good state of health for a remarkably long period of time.