Journal ArticleDOI
Bimodal drug release achieved with multi-layer matrix tablets: transport mechanisms and device design.
TLDR
The aim of this study was to develop new multi-layer matrix tablets to achieve bimodal drug release profiles (fast release/slow release/fast release) and Hydroxypropyl methylcellulose acetate succinate (HPMCAS) was chosen as a matrix former, because it is water-insoluble at low, and water-soluble at high pH values.About:
This article is published in Journal of Controlled Release.The article was published on 2000-12-03. It has received 130 citations till now. The article focuses on the topics: Drug carrier & Dosage form.read more
Citations
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Journal ArticleDOI
Modeling of drug release from delivery systems based on hydroxypropyl methylcellulose (HPMC).
TL;DR: The present article is a comprehensive review of the current state of the art of mathematical modeling drug release from HPMC-based delivery systems and discusses the crucial points of the most important theories.
Journal ArticleDOI
Hydrogels in controlled release formulations: network design and mathematical modeling
Chien-Chi Lin,Andrew T. Metters +1 more
TL;DR: The objective of this article is to review the fundamentals and recent advances in hydrogel network design as well as mathematical modeling approaches related to controlled molecule release from hydrogels.
Journal ArticleDOI
Mathematical modeling of drug delivery.
TL;DR: An overview on the current state of the art of mathematical modeling of drug delivery, including empirical/semi-empirical and mechanistic realistic models is given, Analytical as well as numerical solutions are described and various practical examples are given.
Journal ArticleDOI
Modeling of diffusion controlled drug delivery.
TL;DR: The aim of this article is to give an overview on the current state of the art of modeling drug release from delivery systems, which are predominantly controlled by diffusional mass transport.
Journal ArticleDOI
Bone tissue engineering therapeutics: controlled drug delivery in three-dimensional scaffolds.
TL;DR: This paper provides an extensive overview of published studies on the development and applications of three-dimensional bone tissue engineering (TE) scaffolds with potential capability for the controlled delivery of therapeutic drugs.
References
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Book
The mathematics of diffusion
TL;DR: Though it incorporates much new material, this new edition preserves the general character of the book in providing a collection of solutions of the equations of diffusion and describing how these solutions may be obtained.
Book ChapterDOI
Diffusion in polymer-diluent systems
TL;DR: In this article, the authors discuss some selected topics with which they have a relatively greater acquaintance but which they feel are of fundamental importance for understanding the current situation in this field of polymer research.
Journal ArticleDOI
HPMC-matrices for controlled drug delivery: a new model combining diffusion, swelling, and dissolution mechanisms and predicting the release kinetics.
TL;DR: The practical benefit of the presented model is to identify the required shape and dimensions of drug-loaded HPMC-matrices in order to achieve desired release profiles, thus facilitating the development of new controlled drug delivery products.
Journal ArticleDOI
Hydrophilic Matrices for Controlled Drug Delivery: An Improved Mathematical Model to Predict the Resulting Drug Release Kinetics (the “sequential Layer” Model)
TL;DR: An improved design model is developed that can be used to predict accurately the required composition and dimensions of drug-loaded hydrophilic matrices in order to achieve desired release profiles, thus facilitating the development of new pharmaceutical products.
Journal ArticleDOI
A New Model Describing the Swelling and Drug Release Kinetics from Hydroxypropyl Methylcellulose Tablets
Juergen Siepmann,Juergen Siepmann,Kairali Podual,M. Sriwongjanya,Nicholas A. Peppas,Roland Bodmeier +5 more
TL;DR: A novel mathematical model for the water transport into and drug release from hydroxypropyl methylcellulose (HPMC) tablets is presented and it is shown that the diffusion coefficients strongly depend on the water concentration.