Biocompatibility of aldehyde-fixed bovine pericardium. An in vitro and in vivo approach toward improvement of bioprosthetic heart valves.
Michael Grimm,Elisabeth Eybl,Martin Grabenwöger,Andrea Griesmacher,Udo Losert,Peter Böck,Mathias Müller,Ernst Wolner +7 more
TLDR
Treatment of aldehyde-fixed pericardium with L-glutamic acid at pH 3.5 and storage in a nontoxic, bacteriostatic solution resulted in a lower degree of calcification in 63-day subcutaneous implants in rats, as compared with commercially available tissue.About:
This article is published in The Journal of Thoracic and Cardiovascular Surgery.The article was published on 1991-08-01 and is currently open access. It has received 59 citations till now. The article focuses on the topics: Chemical binding & Biocompatibility.read more
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Acellular vascular tissues: natural biomaterials for tissue repair and tissue engineering
TL;DR: Despite significant advances in the area of cardiovascular prostheses, there has yet to be developed a completely biocompatible, long-lasting implant and the possibility of applying selective cell seeding to naturally derived bioprosthetics moves us closer to a living tissue replacement.
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Development of a pericardial acellular matrix biomaterial: Biochemical and mechanical effects of cell extraction
TL;DR: The pericardial acellular matrix is a promising approach to the production of biomaterials for heart valve or cardiovascular patching applications and showed that, with the exception of slightly increased stress relaxation, the mechanical properties of the fresh tissue were preserved in the pericARDial a cellular matrix.
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Heart Valve Tissue Engineering
TL;DR: The technological details of the 2 main approaches to tissue-engineered heart valves, their rationale, their strengths and weaknesses, and the likely mechanisms for their failure are reviewed.
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Acellular matrix: A biomaterials approach for coronary artery bypass and heart valve replacement
TL;DR: In this paper, a multistep detergentenzymatic extraction process (involving hypotonic and hypertonic solutions, the detergents octyl-phenoxy-polyethoxyethanol and sodium dodecyl sulfate, as well as DNAse and RNAse) was developed, while inhibiting autolysis, removing all cells from tissues and, with them, cellular antigens together with lipids and more soluble glycosaminoglycans.
Journal Article
Acellular matrix : a biomaterials approach for coronary artery bypass and heart valve replacement. Discussion
TL;DR: A multistep detergent-enzymatic extraction process which, while inhibiting autolysis, removes all cells from tissues and, with them, cellular antigens together with lipids and more soluble glycosaminoglycans appears promising for preclinical evaluation.
References
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Biological effects of residual glutaraldehyde in glutaraldehyde‐tanned collagen biomaterials
TL;DR: Observations indicate that leaching of the glutaraldehyde from glutARaldehyde-tanned collagen sponge is sufficient to produce potentially adverse cellular effects both in vivo and in vitro.
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Structural changes in glutaraldehyde-treated porcine heterografts used as substitute cardiac valves: Transmission and scanning electron microscopic observations in 12 patients
TL;DR: In this paper, a comparison of unprocessed porcine valves and unimplanted commercially processed valves showed loss of endothelium and acid mucopolysaccharides during preimplantation processing.
Journal Article
Biologic determinants of dystrophic calcification and osteocalcin deposition in glutaraldehyde-preserved porcine aortic valve leaflets implanted subcutaneously in rats.
TL;DR: Examining the biologic determinants of this type of dystrophic calcification using subcutaneous implants of glutaraldehyde-preserved porcine aortic valve leaflets in rats found that GPVs calcified progressively, with mineral deposition occurring in a morphologic pattern comparable to that noted in clinical retrievals.
Journal Article
The role of glutaraldehyde-induced cross-links in calcification of bovine pericardium used in cardiac valve bioprostheses.
Gershon Golomb,Frederick J. Schoen,Mary Sue Smith,Judith A. Linden,Mark Dixon,Robert J. Levy +5 more
TL;DR: The amount of GLUT incorporated controls the extent of cross-links, which in turn directly determines tissue stability and calcification, in bovine pericardial tissue calcification.
Journal Article
Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components.
TL;DR: The results of this study suggest that the temporally ordered synthesis of specific matrix components plays a significant role in orchestrating the growth and differentiation of endothelial cells during the highly integrated set of responses known as angiogenesis.