Journal ArticleDOI
Calcification of tissue heart valve substitutes: progress toward understanding and prevention.
Reads0
Chats0
TLDR
Current concepts in the pathophysiology of tissue valve calcification are summarized, including emerging concepts of endogenous regulation, progress toward prevention of calcification, and issues related to calcification of the aortic wall of stentless bioprosthetic valves.About:
This article is published in The Annals of Thoracic Surgery.The article was published on 2005-03-01. It has received 651 citations till now. The article focuses on the topics: Pathologic calcification & Calcification.read more
Citations
More filters
Journal ArticleDOI
On the mechanisms of biocompatibility.
TL;DR: It is shown that, in the vast majority of circumstances, the sole requirement for biocompatibility in a medical device intended for long-term contact with the tissues of the human body is that the material shall do no harm to those tissues, achieved through chemical and biological inertness.
Journal ArticleDOI
Two-Year Outcomes after Transcatheter or Surgical Aortic-Valve Replacement
Susheel Kodali,Mathew R. Williams,Craig R. Smith,Lars G. Svensson,John G. Webb,Raj Makkar,Gregory P. Fontana,Todd M. Dewey,Vinod H. Thourani,Augusto D. Pichard,Michael P. Fischbein,Wilson Y. Szeto,Scott Lim,Kevin L. Greason,Paul S. Teirstein,S. Chris Malaisrie,Pamela S. Douglas,Rebecca T. Hahn,Brian Whisenant,Alan Zajarias,Duolao Wang,Jodi J. Akin,William N. Anderson,Martin B. Leon,Trial Investigators +24 more
TL;DR: A 2-year follow-up of patients in the PARTNER trial supports TAVR as an alternative to surgery in high-risk patients, but paravalvular regurgitation was more frequent after T AVR and was associated with increased late mortality.
Journal ArticleDOI
Prosthetic Heart Valves Selection of the Optimal Prosthesis and Long-Term Management
TL;DR: An overview of the current state of knowledge and future perspectives with regard to optimal prosthesis selection and clinical management after valve implantation is provided.
Journal ArticleDOI
Engineering Complex Tissues
TL;DR: This review highlights advances in tissue engineering technologies to enable regeneration of complex tissues and organs and to discuss how such innovative, engineered tissues can affect the clinic.
Journal ArticleDOI
Calcium Orthophosphates in Nature, Biology and Medicine
TL;DR: Calcium orthophosphates are of great significance for humankind and, in this paper, an overview on the current knowledge on this subject is provided.
References
More filters
Journal ArticleDOI
Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein
Guangbin Luo,Patricia Ducy,Marc D. McKee,Gerald J. Pinero,Evelyne M Loyer,Richard R. Behringer,Gerard Karsenty +6 more
TL;DR: Mgp, a mineral-binding ECM protein3 synthesized by vascular smooth-muscle cells and chondrocytes, is the first inhibitor of calcification of arteries and cartilage to be characterized in vivo.
Journal ArticleDOI
Phosphate regulation of vascular smooth muscle cell calcification.
Shuichi Jono,Marc D. McKee,Charles E. Murry,Atsushi Shioi,Yoshiki Nishizawa,Katsuhito Mori,Hirotoshi Morii,Cecilia M. Giachelli +7 more
TL;DR: It is suggested that elevated phosphate may directly stimulate HSMCs to undergo phenotypic changes that predispose to calcification and offer a novel explanation of the phenomenon of vascular calcification under hyperphosphatemic conditions.
Journal ArticleDOI
Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial.
Karl E. Hammermeister,Gulshan K. Sethi,William G. Henderson,Frederick L. Grover,Charles Oprian,Shahbudin H. Rahimtoola +5 more
TL;DR: At 15 years, patients undergoing AVR had a better survival with a mechanical valve than with a bioprosthetic valve, largely because primary valve failure was virtually absent with mechanical valve.
Journal ArticleDOI
Bone morphogenetic protein expression in human atherosclerotic lesions.
Kristina I. Boström,Karol E. Watson,Susan D. Horn,C. M. Wortham,Ira M. Herman,Linda L. Demer +5 more
TL;DR: Findings suggest that arterial calcification is a regulated process similar to bone formation, possibly mediated by pericyte-like cells.
Journal ArticleDOI
Prosthetic heart valves
TL;DR: More than 80 models of prosthetic heart valves have been developed and used since the 1950s and more than 60,000 valve replacements are performed annually in the United States.