Biological evaluation of ferulic acid as potent immunomodulator: An in vitro study
TLDR
The present study suggests that ferulic acid could be regarded as potential immunomodulatory compound, however, it would be interesting to understand in vivo behaviour of ferulic Acid under varied experimental conditions.Abstract:
Objective: The development of immunity and suppression of undesired immune reaction are two of the strategies that are responsible to control the disease. Immunomodulators, which are devoid of any untoward effects, can be administered for a long period for prevention of variety of diseases. Ferulic acid, a hydroxylated cinnamic acid is an abundant phenolic phytochemical found in cell wall of plants. It is one of the important phyto‑molecule with diverse therapeutic effects. The current work was proposed to determine in vitro immunomodulatory effects of ferulic acid. Materials and Methods: Nitroblue tetrazolium test, phagocytosis of killed Candida albicans, neutrophil locomotion and chemotaxis test and membrane stabilisation studies were performed to determine immunomodulatory effect of ferulic acid. Results: Ferulic acid caused stimulation of neutrophils causing phagocytotic activity to significant degree. Ferulic acid aroused the process of phagocytosis of killed C. albicans and demonstrated a significant (P < 0.05) chemotactic activity at all tested concentrations. Ferulic acid at concentrations of 50-300 μg/ml demonstrated protection to goat erythrocytes membrane against lysis induced by heat solution. Conclusion: The present study suggests that ferulic acid could be regarded as potential immunomodulatory compound. However, it would be interesting to understand in vivo behaviour of ferulic acid under varied experimental conditions. Key words: Ferulic acid, immunomodulatory, membrane stabilisationread more
Citations
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Effects of ferulic acid on growth performance, immunity and antioxidant status in genetically improved farmed tilapia (Oreochromis niloticus) fed oxidized fish oil
Journal ArticleDOI
In vitro immunomodulatory, antifungal, and antibacterial screening of Phyllanthus niruri against to human pathogenic microorganisms
TL;DR: P. niruri does not have antifungal activity but has potent immunomodulatory and antibacterial activity, which may be due to the secondary metabolites such as alkaloid, tannins, terpenoids, flavonoids, phenol compounds.
Journal ArticleDOI
In vivo evaluation of immunomodulatory potential of ferulic acid
TL;DR: It can be concluded that Ferulic acid has potential to stimulate overall immune system in the experimental animals.
References
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TL;DR: Since Metschnikoff's discovery, hundreds of scientists studying dozens of species have reported thousands of studies on these cells, perhaps the most widely recognized of which are those of the eminent English scientists.