Journal ArticleDOI
Blood cell proliferation response to beryllium: analysis by receiver-operating characteristics.
R. F. Stokes,Milton D. Rossman +1 more
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TLDR
The proliferative response of blood cells to beryllium has a limited role in screening for chronic berylla disease, and the optimum test parameters and stimulation index cutoff were evaluated.Abstract:
As testing for beryllium-induced proliferation of bronchoalveolar lavage cells is not suitable for screening, we evaluated the proliferative response of blood cells to beryllium Twenty-seven patients with chronic beryllium disease, documented by histology and a positive lung proliferative response to beryllium, were compared to 30 controls A significant difference (p less than 05) was observed between beryllium disease patients and controls with 100 or 10 microM beryllium salts To evaluate the optimum test parameters and stimulation index cutoff, receiver operating characteristic curves (true positive v false positive) were generated Maximum predictive value positive (26%) was observed at a stimulation index cutoff of 25 which corresponds to a 38% sensitivity and 97% specificity This suggests that the blood cell proliferation response to beryllium has a limited role in screening for chronic beryllium diseaseread more
Citations
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Reexamination of the blood lymphocyte transformation test in the diagnosis of chronic beryllium disease
TL;DR: It is concluded that an abnormal blood LTT can be used to diagnose CBD in patients with compatible lung pathology, and split samples for 10 beryllium disease cases and eight control subjects demonstrated that the blood L TT was reproducible between two separate laboratories.
Journal ArticleDOI
An Official American Thoracic Society Statement: Diagnosis and Management of Beryllium Sensitivity and Chronic Beryllium Disease
John R. Balmes,Jerrold L. Abraham,Raed A. Dweik,Elizabeth Fireman,Andrew P. Fontenot,Lisa A. Maier,Joachim Müller-Quernheim,Gaston Ostiguy,Lewis Pepper,Cesare Saltini,Christine R. Schuler,Tim K. Takaro,Paul F. Wambach +12 more
TL;DR: In this paper, a confirmed abnormal beryllium lymphocyte proliferation test without evidence of lung disease is diagnostic of BeS, while evidence of a granulomatous inflammatory response in the lung is diagnostic for CBD.
Journal ArticleDOI
Diagnoses of chronic beryllium disease within cohorts of sarcoidosis patients.
TL;DR: Chronic beryllium disease still belongs to the spectrum of differential diagnoses of granulomatous disorders.
Journal ArticleDOI
State of the Art: Imaging of Occupational Lung Disease
TL;DR: The radiologist must understand the spectrum of expected imaging patterns related to known occupational exposures and must also recognize newly described occupational exposure risks, often related to recent changes in industrial practices.
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John A. Swets,Ronald M. Pickett,Susan F. Whitehead,David J. Getty,James A. Schnur,Joel B. Swets,Barbara Freeman +6 more
TL;DR: A general protocol for rigorous evaluation of diagnostic systems in medicine was applied successfully in a comparative study of two radiologic techniques, and computed tomography was found to be substantially more accurate than radionuclide scanning.
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Maintenance of alveolitis in patients with chronic beryllium disease by beryllium-specific helper T cells.
TL;DR: It is concluded that in patients with chronic beryllium disease, bERYllium acts as a class II-restricted antigen, stimulating local proliferation and accumulation in the lung of berylla-specific CD4+ (helper/inducer) T cells, which is a hypersensitivity disease in which beryLLium is the specific antigen.
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Pathologic and immunologic alterations in early stages of beryllium disease. Re-examination of disease definition and natural history.
TL;DR: It is concluded that use of fiberoptic bronchoscopy with transbronchial biopsy and BAL facilitates diagnosis of beryllium workers who have histopathologic and immunologic alterations consistent with chronic beryLLium disease.