R
Raed A. Dweik
Researcher at Cleveland Clinic
Publications - 256
Citations - 6881
Raed A. Dweik is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Pulmonary hypertension & Asthma. The author has an hindex of 46, co-authored 256 publications receiving 5906 citations. Previous affiliations of Raed A. Dweik include Cleveland Clinic Lerner Research Institute & Cleveland Clinic Lerner College of Medicine.
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Journal ArticleDOI
Pediatric pulmonary hypertension
Debra Boyer,Jessica E. Pittman,Fei Jamie Dy,Ambalavanan Arunachalam,Raed A. Dweik,Steven H. Abman,Kevin C. Wilson,Carey C. Thomson +7 more
TL;DR: An overview of recent information regarding the current approach and diagnostic classification of PAH in children as based on discussions and recommendations from the Pediatric Task Force of the 5th World Symposium on Pulmonary Hypertension (WSPH) in Nice, France is provided.
Journal ArticleDOI
Correlation of Systemic Superoxide Dismutase Deficiency to Airflow Obstruction in Asthma
Suzy A. A. Comhair,Kristin Ricci,Mercedes E. Arroliga,Abigail R. Lara,Raed A. Dweik,Wei Song,Stanley L. Hazen,Eugene R. Bleecker,W. W. Busse,Kian Fan Chung,Benjamin Gaston,Annette T. Hastie,Mark Hew,Nizar N. Jarjour,Wendy C. Moore,Stephen P. Peters,W. Gerald Teague,Sally E. Wenzel,Serpil C. Erzurum +18 more
TL;DR: Findings are consistent with greater oxidant stress in asthma leading to greater inactivation of SOD, which likely amplifies inflammation and progressive airflow obstruction.
Journal ArticleDOI
Alterations of the Arginine Metabolome in Asthma
Abigail R. Lara,Sumita Khatri,Sumita Khatri,Zeneng Wang,Suzy A. A. Comhair,Weiling Xu,Raed A. Dweik,Melanie Bodine,Bruce S. Levison,Jeffrey P. Hammel,Eugene R. Bleecker,William W. Busse,William J. Calhoun,Mario Castro,Fan Chung Kian,Douglas Curran-Everett,Benjamin Gaston,Elliot Israel,Nizar N. Jarjour,Wendy C. Moore,Stephen P. Peters,W. Gerald Teague,Sally E. Wenzel,Stanley A Hazen,Serpil C. Erzurum +24 more
TL;DR: Modeling confirmed that measures of Arg bioavailabilty predict airflow obstruction only in severe asthma, and Unlike Fe(NO), Arg bioavailability is not a surrogate measure of inflammation; however, Arg bio availability is strongly associated with airflow abnormalities insevere asthma.
Journal ArticleDOI
Biomarkers in exhaled breath condensate: a review of collection, processing and analysis
TL;DR: Specific biomarkers studied in specific diseases as well as some of the related technical issues including collection, processing and analysis are discussed.
Journal ArticleDOI
Nitric Oxide Blocks Nuclear Factor- κ B Activation in Alveolar Macrophages
Baisakhi Raychaudhuri,Raed A. Dweik,Mary J. Connors,Lisa T. Buhrow,Anagha Malur,Judith A. Drazba,Alejandro C. Arroliga,Serpil C. Erzurum,Mani S. Kavuru,Mary Jane Thomassen +9 more
TL;DR: This work has shown that in human alveolar macrophages (AM), NO decreased inflammatory cytokine production, including that of interleukin-1β, tumor necrosis factor-α and macrophage inflammatory protein-1α, and prevented an LPS-mediated decrease in the NF-κB inhibitory protein IκB-α.