Journal ArticleDOI
Blood pressure levels and hypertension prevalence in a high selenium environment: results from a cross-sectional study
Marco Vinceti,Marco Vinceti,Rajinder Chawla,Tommaso Filippini,C. Dutt,Silvia Cilloni,Rohit Loomba,Annalisa Bargellini,Nicola Orsini,Karaj S. Dhillon,Paul K. Whelton +10 more
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TLDR
Overall, the findings suggest that chronic overexposure to environmental selenium may increase blood pressure, though there were inconsistencies for this association according to the choice of exposure indicator, the study endpoint and the sex.Abstract:
Background and aims Recent human and laboratory studies have suggested the possibility that selenium overexposure may increase blood pressure. We sought to ascertain whether adults living in a seleniferous area exhibit an association between selenium exposure and both blood pressure levels as well as prevalence of hypertension. Methods and results We measured selenium levels in blood (serum), hair and nail samples obtained from 680 adult volunteers (267 men and 413 women), living in seven Punjabi villages in a seleniferous area and related them to health outcomes, including systolic and diastolic blood pressure and presence of hypertension. In a multivariable restricted cubic spline regression model, adjusted for age, sex and history of hypertension, we found a positive association between systolic blood pressure and both serum (P = 0.004) and hair (P = 0.058) selenium levels, but not with nail selenium content. Little association emerged between the three selenium biomarkers and diastolic blood pressure. Hypertension prevalence was positively associated with the three exposure indicators (P Conclusions Overall, these findings suggest that chronic overexposure to environmental selenium may increase blood pressure, though there were inconsistencies for this association according to the choice of exposure indicator, the study endpoint and the sex.read more
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Toxicology and pharmacology of synthetic organoselenium compounds: an update.
TL;DR: In this paper, the authors addressed the pharmacology and toxicology of synthetic organoselenium compounds and some naturally occurring organOSElenium amino acids, including diselenides and ebselenides.
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Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis.
TL;DR: Physiologically high selenium levels in the body are associated with decreased risk for CVD incidence and mortality, however, people should be cautious about the potential harmful effects from excessive intake of seenium.
Journal ArticleDOI
Exposure to a high selenium environment in Punjab, India: Biomarkers and health conditions
Rajinder Chawla,Tommaso Filippini,Rinchu Loomba,Silvia Cilloni,Karaj S. Dhillon,Marco Vinceti,Marco Vinceti +6 more
TL;DR: Overall, and despite some statistical imprecision in effect estimates, these results confirm the occurrence of adverse health effects in subjects exposed to high levels of environmental selenium.
Journal ArticleDOI
Selenium, Zinc, Chromium, and Vanadium Levels in Serum, Hair, and Urine Samples of Obese Adults Assessed by Inductively Coupled Plasma Mass Spectrometry
Alexey A. Tinkov,Alexey A. Tinkov,Margarita G. Skalnaya,Olga P. Ajsuvakova,Eugeny P. Serebryansky,Jane C.J. Chao,Jane C.J. Chao,Michael Aschner,Michael Aschner,Anatoly V. Skalny,Anatoly V. Skalny +10 more
TL;DR: The results established that obese subjects were characterized by 47% and 30% lower serum Cr and V levels compared with controls, respectively, whereas serum Se levels exceeded control values by 9%.
Journal ArticleDOI
The importance of selenium and zinc deficiency in cardiovascular disorders.
Paweł Gać,Karolina Czerwińska,Piotr Macek,Aleksandra Jaremków,Grzegorz Mazur,Krystyna Pawlas,Rafał Poręba +6 more
TL;DR: Current views on the relationship between the concentration of trace elements such as selenium and zinc in the body, as well as morphology and function of the cardiovascular system are presented.
References
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Journal ArticleDOI
Selenium in human health and disease.
Susan J. Fairweather-Tait,Yongping Bao,Martin R. Broadley,Rachel Collings,Dianne Ford,John E. Hesketh,Rachel Hurst +6 more
TL;DR: The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies.
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Hypertension in India: A systematic review and meta-analysis of prevalence, awareness, and control of hypertension
Raghupathy Anchala,Nanda Kishore Kannuri,Hira B Pant,Hassan Khan,Oscar H. Franco,Emanuele Di Angelantonio,Dorairaj Prabhakaran +6 more
TL;DR: A region-specific (urban and rural parts of north, east, west, and south India) systematic review and meta-analysis of the prevalence, awareness, and control of hypertension among Indian patients have not been done before and about 33% urban and 25% rural Indians are hypertensive.
Journal ArticleDOI
Methods of assessment of iodine status in humans: a systematic review
Danijela Ristic-Medic,Zlata Piskáčková,Lee Hooper,Jiri Ruprich,Amelie Casgrain,Kate Ashton,Mirjana Pavlović,Marija Glibetić +7 more
TL;DR: This systematic review confirms that in healthy individuals, plasma, urinary, and hair zinc are reliable biomarkers of zinc status, and further high-quality studies are required, particularly in infants, adolescents, and immigrant population groups for whom there are limited data.
Journal ArticleDOI
Selenium for preventing cancer
Gabriele Dennert,Marcel Zwahlen,Maree Brinkman,Marco Vinceti,Maurice P. Zeegers,Markus Horneber +5 more
TL;DR: Findings have limitations due to study design, quality and heterogeneity that complicate interpretation of the summary statistics, and some studies suggested that genetic factors may modify the relation between selenium and cancer risk-a hypothesis that deserves further investigation.
Journal ArticleDOI
Oxidative Stress, Inflammation, and Vascular Aging in Hypertension.
Tomasz J. Guzik,Rhian M. Touyz +1 more
TL;DR: Oxidative stress and inflammation, key mechanisms of endothelial dysfunction and arterial damage, link these risk factors to vascular disease, arterial stiffness, and aging.