Journal ArticleDOI
Boron clusters in medicinal chemistry: perspectives and problems
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In this paper, the perspectives of boron clusters for drug design and problems to be solved for a broader application are discussed, and a list of actions is given for overcoming the problems.Abstract:
Abstract Boron clusters have been employed successfully as constituents in bioactive substances. In this review, the perspectives of boron clusters for drug design and problems to be solved for a broader application are discussed, and a list of actions is given for overcoming the problems.read more
Citations
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Challenges and Opportunities for the Application of Boron Clusters in Drug Design.
TL;DR: This Perspective presents an overview of the properties of boron clusters that are pertinent for drug discovery, recent applications in the design of various classes of drugs, and the potential use of boreon clusters in the construction of new pharmaceuticals.
Journal ArticleDOI
Blue Phosphorescent Zwitterionic Iridium(III) Complexes Featuring Weakly Coordinating nido-Carborane-Based Ligands.
Jonathan C. Axtell,Kent O. Kirlikovali,Peter I. Djurovich,Dahee Jung,Vinh T. Nguyen,Brian Munekiyo,A. Timothy Royappa,A. Timothy Royappa,Arnold L. Rheingold,Alexander M. Spokoyny +9 more
TL;DR: The development of a new class of phosphorescent zwitterionic bis(heteroleptic) Ir(III) compounds containing pyridyl ligands with weakly coordinating nido-carboranyl substituents is reported, suggesting that the use of a ligand framework containing aWeakly coordinating anionic component can provide a new avenue for designing efficient Ir( III)-based phosphorescent emitters.
Journal ArticleDOI
Recent developments with boron as a platform for novel drug design
TL;DR: The present status of boron resembles the medicinal chemistry status of fluorine three decades ago; indeed, currently, approximately 20% of pharmaceuticals on the market contain fluorine.
Journal ArticleDOI
Palladium-Catalyzed Selective Five-Fold Cascade Arylation of the 12-Vertex Monocarborane Anion by B-H Activation
Furong Lin,Jing-Lu Yu,Yunjun Shen,Shuo-Qing Zhang,Bernhard Spingler,Jiyong Liu,Xin Hong,Simon Duttwyler +7 more
TL;DR: A series of cage penta-arylated carboranes have been synthesized by palladium-catalyzed intermolecular coupling of the C-carboxylic acid of the monocarba- closo-dodecaborate anion with iodoarenes by direct cage B-H bond functionalization, setting a record in terms of one-pot directing group-mediated activation of inert bonds in a single molecule.
Journal ArticleDOI
Boron cluster compounds as new chemical leads for antimicrobial therapy
Krzysztof Fink,Mariusz Uchman +1 more
TL;DR: Boron cluster compounds have the potential to become new chemical leads in antimicrobial therapy because their derivatives show promising antimicrobial activity and low sensitivity to both genetic and phenotypic mechanisms of pathogen resistance as discussed by the authors.
References
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A new intermolecular interaction: unconventional hydrogen bonds with element-hydride bonds as proton acceptor.
Robert H. Crabtree,Per E. M. Siegbahn,Odile Eisenstein,Arnold L. Rheingold,Thomas F. Koetzle +4 more
TL;DR: A new type of intermolecular interaction is described, which operates between a conventional hydrogen bond donor such as an NH or OH bond as the weak acid component and an element-hydride bond as a weak base component, where the element in question can be a transition metal or boron.
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Preparation and characterization of the (3)-1,2- and (3)-1,7-dicarbadodecahydroundecaborate(-1) ions
M. Frederick Hawthorne,Donald C. Young,Philip M. Garrett,David Alan Owen,Sarah G. Schwerin,Fred N. Tebbe,Patrick A. Wegner +6 more
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From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease
Petr Cigler,Petr Cigler,Milan Kožíšek,Pavlína Řezáčová,Pavlína Řezáčová,Jiří Brynda,Zbyszek Otwinowski,Jana Pokorná,Jaromír Plešek,Bohumír Grüner,Lucie Dolečková-Marešová,Martin Máša,Juraj Sedlacek,Jochen Bodem,Hans-Georg Kräusslich,Vladimír Král,Jan Konvalinka,Jan Konvalinka +17 more
TL;DR: The potent, specific, and selective competitive inhibition of HIV PR by substituted metallacarboranes is reported, and it is suggested that these compounds block flap closure in addition to filling the corresponding binding pockets as conventional PIs.
Journal ArticleDOI
Design of HIV protease inhibitors based on inorganic polyhedral metallacarboranes.
Pavlina Rezacova,Jana Pokorná,Jana Pokorná,Jiri Brynda,Milan Kozisek,Milan Kozisek,Petr Cigler,Petr Cigler,Martin Lepšík,Jindrich Fanfrlík,Jan Rezac,Klára Grantz Šašková,Klára Grantz Šašková,Irena Sieglová,Jaromír Plešek,Václav Šícha,Bohumír Grüner,Heike Oberwinkler,Juraj Sedlacek,Hans-Georg Kräusslich,Pavel Hobza,Vladimír Král,Jan Konvalinka,Jan Konvalinka +23 more
TL;DR: The results prove the capacity of linker-substituted dual-cage cobalt bis(dicarbollides) as lead compounds for design of more potent inhibitors of HIV PR.
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The first CNS-active carborane: A novel P2X7 receptor antagonist with antidepressant activity.
Shane M. Wilkinson,Hendra Gunosewoyo,Melissa L. Barron,Aurelie A. Boucher,Michelle N. McDonnell,Peter Turner,Daniel E. Morrison,Max R. Bennett,Iain S. McGregor,Louis M. Rendina,Michael Kassiou +10 more
TL;DR: It is demonstrated, for the first time, that a carborane has the capacity to modify CNS activity.