Brain-derived neurotrophic factor val66met genotype and early life stress effects upon bipolar course.
Shefali Miller,Joachim Hallmayer,Po W. Wang,Shelley J. Hill,Sheri L. Johnson,Terence A. Ketter +5 more
TLDR
Between group comparisons, it was suggested BDNF met allele carrier genotype might amplify negative effects of ELS upon BD illness severity/chronicity, although with regression analysis, there was not a significant gene-environment interaction.About:
This article is published in Journal of Psychiatric Research.The article was published on 2013-02-01 and is currently open access. It has received 44 citations till now. The article focuses on the topics: Sexual abuse & Severity of illness.read more
Citations
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Paradise Lost: The Neurobiological and Clinical Consequences of Child Abuse and Neglect
TL;DR: This Review summarizes many of the persistent biological alterations associated with childhood maltreatment including changes in neuroendocrine and neurotransmitter systems and pro-inflammatory cytokines in addition to specific alterations in brain areas associated with mood regulation.
Journal ArticleDOI
Childhood maltreatment and unfavourable clinical outcomes in bipolar disorder: a systematic review and meta-analysis
TL;DR: Childhood maltreatment predicts unfavourable clinical features and course of illness in patients with bipolar disorder and these associations were not explained by publication bias, undue effects of individual studies, or variation in study quality.
Journal ArticleDOI
The role of childhood trauma in bipolar disorders
Monica Aas,Monica Aas,Chantal Henry,Ole A. Andreassen,Ole A. Andreassen,Frank Bellivier,Ingrid Melle,Ingrid Melle,Bruno Etain +8 more
TL;DR: This review contributes to a new understanding of the negative consequences of early life stress, as well as setting childhood trauma in a biological context of susceptibility and discussing novel long-term pathophysiological consequences in bipolar disorders.
Journal ArticleDOI
The genetics of bipolar disorder.
TL;DR: As the understanding of the genetics of BD improves, there is growing optimism that some clear biological pathways will emerge, providing a basis for future studies aimed at molecular diagnosis and novel therapeutics.
Journal ArticleDOI
Interactions Between Variation in Candidate Genes and Environmental Factors in the Etiology of Schizophrenia and Bipolar Disorder: a Systematic Review.
Błażej Misiak,Filip Stramecki,Łukasz Gawęda,Łukasz Gawęda,Katarzyna Prochwicz,Maria M. Sąsiadek,Ahmed A. Moustafa,Dorota Frydecka +7 more
TL;DR: A systematic review of studies investigating gene × environment interactions in BD and schizophrenia spectrum phenotypes revealed that polymorphisms in COMT, BDNF, and FKBP5 genes might interact with early life stress and cannabis abuse or dependence, influencing various outcomes of schizophrenia spectrum disorders and BD.
References
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Journal Article
The Mini-International Neuropsychiatric Interview (M.I.N.I.) : The development and validation of a Structured Diagnostic Psychiatric Interview for DSM-IV and ICD-10
David V. Sheehan,Yves Lecrubier,Kathy Harnett Sheehan,P. Amorim,J. Janavs,Emmanuelle Weiller,T. Hergueta,Ross A. Baker,Dunbar Geoffrey Charles +8 more
TL;DR: The Mini-International Neuropsychiatric Interview is designed to meet the need for a short but accurate structured psychiatric interview for multicenter clinical trials and epidemiology studies and to be used as a first step in outcome tracking in nonresearch clinical settings.
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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
TL;DR: Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.
Journal ArticleDOI
The mini international neuropsychiatric interview
TL;DR: The results are interpreted as a support for the hypothesis that language-related brain functions are deficient in subgroups of schizophrenia and might be associated with compensatory contralateral activation.
Journal ArticleDOI
Development and validation of a brief screening version of the Childhood Trauma Questionnaire
David P. Bernstein,Judith A. Stein,Michael D. Newcomb,Edward A. Walker,David L. Pogge,Taruna Ahluvalia,John M. Stokes,Leonard Handelsman,Martha A. Medrano,David P. Desmond,William A. Zule +10 more
TL;DR: These findings support the viability of the CTQ-SF across diverse clinical and nonreferred populations and demonstrated good criterion-related validity in a subsample of adolescents on whom corroborative data were available.