Journal ArticleDOI
Cancer in the elderly: why so badly treated?
I.S. Fentiman,Umberto Tirelli,S. Monfardini,M. Schneider,J. Festen,Francesco Cognetti,M.S. Aapro +6 more
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This article is published in The Lancet.The article was published on 1990-04-28. It has received 336 citations till now.read more
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A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients.
Daniel J. Sargent,Richard M. Goldberg,Stacy D. Jacobson,John S. Macdonald,Roberto Labianca,Daniel G. Haller,Lois E. Shepherd,Jean Francois Seitz,Guido Francini +8 more
TL;DR: In this article, a pooled analysis of individual patient data from seven phase 3 randomized trials (involving 3351 patients) in which the effects of postoperative fluorouracil plus leucovorin (five trials) or fluorourocil plus levamisole (two trials) were compared with surgery alone in patients with stage II or III colon cancer was performed.
Journal ArticleDOI
Comprehensive Geriatric Assessment Adds Information to Eastern Cooperative Oncology Group Performance Status in Elderly Cancer Patients: An Italian Group for Geriatric Oncology Study
Lazzaro Repetto,Lucia Fratino,Riccardo A. Audisio,Antonella Venturino,Walter Gianni,Marina Vercelli,Stefano Parodi,Denise Dal Lago,Flora Gioia,Silvio Monfardini,Matti Aapro,Diego Serraino,Vittorina Zagonel +12 more
TL;DR: The CGA adds substantial information on the functional assessment of elderly cancer patients, including patients with a good PS, and the role of PS as unique marker of functional status needs to be reappraised among elderlycancer patients.
Journal ArticleDOI
Male breast cancer
TL;DR: In this article, the authors discuss the risk factors for male breast cancer, including hyperoestrogenization resulting from Klinefelter's, gonadal dysfunction, obesity, or excess alcohol, all increase risk as does exposure to radiation.
Journal ArticleDOI
Systematic Review of Barriers to the Recruitment of Older Patients With Cancer Onto Clinical Trials
TL;DR: Specific clinical trials confined to older patients should be conducted to evaluate tumor biology, treatment tolerability, and the effect of comorbid conditions, and protocol designs need to stratify for age and be less restrictive with respect to exclusions on functional status,Comorbidity, and previous cancers, such that results are generalizable to Older patients.
Journal ArticleDOI
Cancer burden in the aged: an epidemiologic and demographic overview.
TL;DR: In this article, the authors provided an overview of aspects of the burden of cancer in the elderly, highlighting certain demographic and epidemiologic data, which served as a frame of reference for participants in the Oncology Geriatric Education Retreat, San Juan, Puerto Rico, February 21-26, 1997.
References
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Journal ArticleDOI
Choice of cancer therapy varies with age of patient.
TL;DR: Analysis of cancer cases collected by the New Mexico Tumor Registry shows that cancer therapy varies with age and suggests that decision making regarding therapy is influenced by the presence of other diseases.
Journal ArticleDOI
Non-Hodgkin's lymphomas in 137 patients aged 70 years or older: a retrospective European Organization for Research and Treatment of Cancer Lymphoma Group Study.
Umberto Tirelli,Vittorina Zagonel,Diego Serraino,José Thomas,B. Hoerni,A Tangury,U. Ruhl,Pierre Bey,N Tubiana,W P Breed +9 more
TL;DR: Response was similar between the two treatment groups, but severe and lethal toxicity was significantly higher among patients treated with aggressive therapy, and Prospective randomized studies are clearly needed to define the optimal treatment in elderly patients with advanced unfavorable NHL.
Journal ArticleDOI
Cancer in the Elderly: Basic Science and Clinical Aspects
David A. Lipschitz,Samuel Goldstein,Robert J. Shmookler Reis,Marc E. Weksler,Rubin Bressler,Barbara A. Neilan +5 more
TL;DR: The effects of drug use in the elderly and implications for management are examined, and current information on how age may influence the response of cancer to therapy is discussed.
Journal ArticleDOI
Efficacy of tamoxifen as the primary treatment of operable breast cancer in the high risk patient.
TL;DR: An audit of breast cancer patients, considered to be of high operative risk and treated only with Tamoxifen was performed, found all cases were potentially operable and salvage surgery had no operative mortality.
Journal Article
Non Hodgkin's Lymphomas in 137 patients aged 70 years or older: a retrospective EORTC Lymphoma Group Study
Umberto Tirelli,Vittorina Zagonel,Diego Serraino,José Thomas,B. Hoerni,A. Tanguy,U. Ruhl,Pierre Bey,M. Tubiana,W.P.M. Breed,Klaas J. Roozendaal,Anton Hagenbeek,P.S. Hupperets,Riet Somers +13 more
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