Journal ArticleDOI
Carbon tetrachloride-induced protection against carbon tetrachloride toxicity. The role of the liver microsomal drug-metabolizing system.
TLDR
The exact parallelism between depression of liver microsomal mixed function oxidase activity and resistance to the lethal effects of carbon tetrachloride affords strong evidence for the view that metabolism of CO2 by the livermicrosomal drug-metabolizing system is a necessary prerequisite for the toxicity of this liver poison.About:
This article is published in Biochemical Pharmacology.The article was published on 1972-06-15. It has received 131 citations till now. The article focuses on the topics: Carbon tetrachloride & Toxicity.read more
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Journal ArticleDOI
Mechanisms of carbon tetrachloride toxicity
TL;DR: Le CCl 4 provoque une degenerescence lipidique et une necrose centrolobulaire du foie dans la peroxydation lipidique and les troubles hepatocellulaires de l'homeostase du calcium.
Journal ArticleDOI
Carbon tetrachloride hepatotoxicity: an example of lethal cleavage
Rechnagel Ro,Glende Ea +1 more
TL;DR: In this paper, an example of Lethal Cleavage is presented. But it is based on Carbon Tetrachloride Hepatotoxicity (CTH) and it does not consider the effect of carbon dioxide.
Reference EntryDOI
Biotransformation of Xenobiotics
TL;DR: The metabolic fate of a xenobiotic can have an important bearing on its toxic potential, the disposition of the compound in the body and the excretion of the compounds.
Journal ArticleDOI
Pathological mechanisms in carbon tetrachloride hepatotoxicity.
TL;DR: Data do not support the view that an increase in cytosolic free calcium is important in the toxic action of carbon tetrachloride or bromotrichloromethane, and carbon t trichlorometrichylperoxy-induced inhibition of very low density lipoprotein secretion by hepatocytes is not a result of elevated levels of cytosoli free calcium.
Journal ArticleDOI
Three models of free radical-induced cell injury.
TL;DR: Three models of free radical-induced cell injury are presented and, at least in the menadione-induced cytotoxicity, lipid peroxidation is not involved.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
The Carbon Monoxide-binding Pigment of Liver Microsomes I. EVIDENCE FOR ITS HEMOPROTEIN NATURE
Tsuneo Omura,Ryo Sato +1 more
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
Journal ArticleDOI
The colorimetric estimation of formaldehyde by means of the Hantzsch reaction
TL;DR: A chronology of key events leading up to and including the birth of Bonnichsen, R. K. & Bonner, J. (1952).
Journal ArticleDOI
Early onset of lipoperoxidation in rat liver after carbon tetrachloride administration.
TL;DR: To the authors' knowledge this explosive peroxidative decomposition of liver cell microsomal lipids is the most rapid pathological alteration yet noted for carbon tetrachloride liver damage under comparable conditions of dosage and route of administration of this toxic haloalkane.
Journal Article
Lipoperoxidation as a vector in carbon tetrachloride hepatotoxicity.
Recknagel Ro,Ghoshal Ak +1 more