Journal ArticleDOI
Cardiac troponin I and troponin T: Are enzymes still relevant as cardiac markers?
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TLDR
G glycogen phosphorylase isoenzyme BB is a promising enzyme for the early detection of ischemic myocardial damage and should be restricted at present to clinical settings that really require their high specificity.About:
This article is published in Clinica Chimica Acta.The article was published on 1997-01-03. It has received 113 citations till now. The article focuses on the topics: Troponin complex & Troponin T.read more
Citations
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Journal ArticleDOI
Troponin: the biomarker of choice for the detection of cardiac injury
Luciano Babuin,Allan S. Jaffe +1 more
TL;DR: The science underlying the use of troponin biomarkers, how to interpret Troponin values properly and how to apply these measurements to patients who present with possible cardiovascular disease are discussed.
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Troponin T: genetics, properties and function
TL;DR: Troponin T has recently aroused clinical interest in its potential for detecting myocardial damage and the association of mutations in the cardiac isoform with hypertrophic cardiomyopathy.
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Troponin I: Inhibitor or facilitator
TL;DR: TN-I occurs as a homologous group of proteins which form part of the regulatory system of vertebrate and invertebrate striated muscle and induces changes in those proteins with which it interacts, that are essential for their function.
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Cardiac troponin I as a predictor of major cardiac events in emergency department patients with acute chest pain
Carisi Anne Polanczyk,Thomas H. Lee,E. Francis Cook,Ron M. Walls,Donald R. Wybenga,Gail Printy-Klein,Lynn E. Ludwig,Gretchen Guldbrandsen,Paula A. Johnson +8 more
TL;DR: In patients presenting to the ED with acute chest pain, cTnI was an independent predictor of major cardiac events, However, the positive predictive value of an abnormal assay result was not high in this heterogeneous cohort.
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Troponin T concentrations 72 hours after myocardial infarction as a serological estimate of infarct size
Manuela Licka,Rainer Zimmermann,Jörg Zehelein,Thomas J. Dengler,Hugo A. Katus,Wolfgang Kübler +5 more
TL;DR: The data show that a single measurement of circulating troponin T 72 hours after onset of chest pain—independent of reperfusion—is superior for the estimation of myocardial infarct size to measurement of peak CK, CK-MB, or LDH, which require serial determinations and depend on coronary reperfusions.
References
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Lactic dehydrogenase activity in blood.
Felix Wróblewski,John S. Ladue +1 more
TL;DR: Lactic dehydrogenase like serum glutamic oxaloacetic transaminase rises in a characteristic fashion following myocardial infarction, and is associated with a rise in serum lactic dehydrogensase activity.
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Biochemical markers of myocardial injury. Is MB creatine kinase the choice for the 1990s
TL;DR: Although tests for the MB isoenzyme of creatine kinase in plasma have served all of these purposes for nearly three decades, increases in MBCK are not as specific for myocardial injury as first believed and occur too late for optimal early diagnosis of infarction or prompt detection of coronary recanalization.
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Intracellular compartmentation of cardiac troponin T and its release kinetics in patients with reperfused and nonreperfused myocardial infarction.
TL;DR: The aims of the present study were to investigate the intracellular compartmentation of troponin T and to analyze the effects of AMI reperfusion on the appearance kinetics of cardiac trop on the first day after AMI, finding a marked peak in trop onin T serum concentrations at 14 hours after the onset of pain.
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Serum Glutamic Oxaloacetic Transaminase Activity in Human Acute Transmural Myocardial Infarction
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Development of monoclonal antibodies for an assay of cardiac troponin-I and preliminary results in suspected cases of myocardial infarction.
TL;DR: A double monoclonal "sandwich" enzyme immunoassay to measure cardiac troponin-I (cTnI) in serum, which is more cardiac-specific than is CK- MB and remains increased longer than does CK-MB.