Journal ArticleDOI
Cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 155). I. Peripheral sympathetic system.
TLDR
It is concluded that although ST 155 induced a certain degree of α-adrenergic blockade, this effect is not sufficient to account for the hypotensive action of the drug.About:
This article is published in European Journal of Pharmacology.The article was published on 1968-03-01. It has received 104 citations till now. The article focuses on the topics: Sympathetic nervous system & Reserpine.read more
Citations
More filters
Journal ArticleDOI
Inhibition of both noradrenergic and serotonergic neurons in brain by the alpha-adrenergic agonist clonidine.
TL;DR: It is concluded that systemically administered clonidine inhibits the firing of brain NE neurons by acting directly upon adrenergic receptors located on or near the soma of these neurons but that the concomitant inhibition of 5-HT neurons is an indirect effect (possibly secondary to an impairment in noracrenergic transmission).
Journal ArticleDOI
Evidence for an α-sympathomimetic component in the effects of catapresan on vasomotor centres: Antagonism by piperoxane
TL;DR: Results support an α-adrenergic component in the inhibitory effect of catapresan on vasomotor centres and in dogs, decrease in blood pressure, heart rate and aortic blood flow induced by intracisternal injection of piperoxane was reduced or reversed.
Journal ArticleDOI
Inhibition of adrenergic neurotransmission by clonidine: An action on prejunctional α-receptors
Klaus Starke,K.P. Altmann +1 more
TL;DR: It is concluded that clonidine shares with other sympathomimetic agents the ability to depress the liberation of noradrenaline by an action on α-receptors which may be localized prejunctionally.
References
More filters
Journal Article
Reactions of strips of rabbit aorta to epinephrine, isopropylarterenol, sodium nitrite and other drugs.
TL;DR: The relation of the observed curves to theoretical curves predicted by Clark9s equation has been discussed and the time-characteristics of contraction on addition, and of relaxation after washout, of epinephrine and certain other drugs have been described.
Journal ArticleDOI
A method of stimulating the complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat
J. S. Gillespie,T. C. Muir +1 more
Journal ArticleDOI
Pithed Rat Preparation Suitable for Assaying Pressor Substances
R. E. Shipley,John H. Tilden +1 more
TL;DR: A simple method is described for setting up a sensitive pithed rat preparation suitable for assaying small quantities of pressor substances and it is shown that this method can be used for assays of sensitive substances.
Journal Article
Actions and interactions of norepinephrine, tyramine and cocaine on aortic strips of rabbit and left atria of guinea pig and cat.
TL;DR: The actions and interactions of norepinephrine, tyramine and cocaine were studied on strips of thoracic aorta from rabbits and on electrically driven left atria from guinea pigs to develop a hypothetical scheme for the relationship between effector cells and structures.
Journal ArticleDOI
Cardiovascular effects of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 115): II. Central sympathetic structures
TL;DR: In this article, the influence of 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride (ST 155) on spontaneous discharges of sympathetic nerve and on evoked discharges elicited by chemostimulant drugs or electrical stimulation of sympathetic structures of the brain stem was investigated.
Related Papers (5)
Investigations into the mechanism of the hypotensive effect of 2-(2,6-dichlorphenylamino)-2-imidazoline-HCl.
W. Kobinger,A. Walland +1 more
Acute hypotensive action of 2-(2,6-dichlorophenylamino)- 2-imidazoline hydrochloride (St 155) after infusion into the cat's vertebral artery
R. W. Sattler,P. A. van Zwieten +1 more