A method of stimulating the complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat
J. S. Gillespie,T. C. Muir +1 more
About:
This article is published in British journal of pharmacology and chemotherapy.The article was published on 1967-05-01 and is currently open access. It has received 295 citations till now. The article focuses on the topics: Sympathetic nervous system & Spinal cord.read more
Citations
More filters
Journal ArticleDOI
OPC-21268, an orally effective, nonpeptide vasopressin V1 receptor antagonist
Yoshitaka Yamamura,Hidenori Ogawa,Tomihiko Chihara,Kazumi Kondo,Toshiyuki Onogawa,Shigeki Nakamura,Toyoki Mori,Michiaki Tominaga,Youichi Yabuuchi +8 more
TL;DR: An orally effective, nonpeptide, vasopressin V1 receptor antagonist, OPC-21268, has been identified and may be therapeutically useful in the treatment of hypertension and congestive heart failure.
Journal ArticleDOI
Pharmacological profile of valsartan: a potent, orally active, nonpeptide antagonist of the angiotensin II AT1-receptor subtype.
Leoluca Criscione,Marc de Gasparo,Peter Buhlmayer,Steven Whitebread,Hans-peter R. Ramjoué,Jeanette Marjorie Wood +5 more
TL;DR: It is demonstrated that valsartan is a potent, specific, highly selective antagonist of AII at the AT1‐receptor subtype and does not possess agonistic activity, and is an efficacious, orally active, blood pressure‐lowering agent in conscious renal hypertensive rats and in conscious normotensive, sodium‐depleted primates.
Journal ArticleDOI
A method of stimulating different segments of the autonomic outflow from the spinal column to various organs in the pithed cat and rat
TL;DR: The level and number of segments stimulated was altered by varying the depth of insertion of the Teflon tube and the length of central steel electrode protruding from it, and the degree of localization of the stimulus seemed satisfactory since it was possible by stimulating the sacral parasympathetic outflow to the bladder and colon or the lumbar sympathetic outflowTo elicit responses from these organs with little effect on the cardiovascular system.
Journal ArticleDOI
Circulating atrial natriuretic peptides in conscious rats: regulation of release by multiple factors.
TL;DR: Results obtained with the denervated-heart preparation indicate that neuronal influences are important in the release of ANP's induced by volume loading, and the circulating physiologically important ANP’s in the conscious rodent appear to be alpha-rANP(5-28) (atriopeptin III) and either alpha- rANP (3- 28) [ANF[ANF(8-33] or alpha-RANP) (ANF).
OtherDOI
Adrenergic Regulation of Vascular Smooth Muscle
TL;DR: This article describes the Morphological and Functional Plasticity of Adrenergic Neurons, and the Factors Influencing Development and Maturation of Peripheral Sympathetic Nerve Terminals.
References
More filters
Journal ArticleDOI
Acetylcholine metabolism of a sympathetic ganglion
R. Birks,F. C. MacIntosh +1 more
TL;DR: The synthesis, storage, and release of acetylcholine were studied in perfused and intact superior cervical ganglia of cats and determined by bio-assay in ganglion extracts and in the venous ganglia.
Related Papers (5)
Simultaneous radioenzymatic determination of plasma and tissue adrenaline, noradrenaline and dopamine within the femtomole range.
Mosé Da Prada,Gerhard Zürcher +1 more