Journal ArticleDOI
Catecholamine accumulation in tissues of thiamine-deficient rats after inhibition of monoamine oxidase
TLDR
The increase in the catecholamine levels in tissues after inhibition of monoamine oxidase by pheniprazine was slower in thiamine deficient rats than in control animals.About:
This article is published in European Journal of Pharmacology.The article was published on 1970-10-01. It has received 12 citations till now. The article focuses on the topics: Monoamine oxidase B & Thiamine.read more
Citations
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Journal ArticleDOI
Thiamin and the brain.
TL;DR: The body’s ability to discriminate between “good” and “bad” brains is investigated in more detail in a bid to reduce the likelihood of false positives in the diagnosis of autism.
Journal ArticleDOI
Neurotransmitter function in thiamine-deficiency encephalopathy
TL;DR: There is convincing evidence for a central muscarinic cholinergic lesion in pyrithiamine-treated rats and neuropharmacological studies show that this lesion is partially responsible for the neurological deficit resulting from this treatment.
Journal ArticleDOI
Dopamine, Acetylcholine, and Glutamate Interactions in Aging Behavioral and Neurochemical Correlates
Gary B. Freeman,Gary E. Gibson +1 more
TL;DR: An understanding of the interactions of neurotransmitters in hypoxia and thiamin deficiency aids the understanding of normal aging and increases the possibility of developing better treatments for the multiple neurotransmitter deficiencies that accompany many metabolic, age-related, and chronic degenerative disorders.
Journal ArticleDOI
GABA-transaminase and glutamic acid decarboxylase changes in the brain of rats treated with pyrithiamine
TL;DR: Following return to a normal diet, GAD activity was significantly recovered in all areas except the thalamus, and GABA-T staining recovered, at least partially, in all parts of the brain affected.
Journal ArticleDOI
Effect of age on behavioral and enzymatic changes during thiamin deficiency
TL;DR: The current mouse model is an attractive one to study the interaction of thiamin deficiency with aging and the activity of KGDH in the aged brain was more sensitive to thiam in deficiency than in the young.
References
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Journal ArticleDOI
Tyrosine hydroxylase. the initial step in norepinephrine biosynthesis.
TL;DR: It has now been possible to demonstrate that brain, adrenal medulla, and sympathetically innervated tissues contain a specific hydroxylase that catalyzes the conversion of L-tyrosine to dopa.
Journal Article
Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart
TL;DR: Factors indicate that conversion of tyrosine to dopa is the rate-limiting step in the formation of norepinephrine in the sympathetic nervous system and ascorbic acid has been shown to be a requirement for purified dopamine-β-oxidase activity.
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The regulation of norepinephrine synthesis in sympathetic nerves: effect of nerve stimulation, cocaine, and catecholamine-releasing agents.
TL;DR: The results indicate that the concentration of free intraneuronal norepinephrine may be an important factor in the regulation of the rate of synthesis of norpinephrine in the intact neuron.
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The influence of monoamine oxidase inhibition on catecholamine synthesis
Norton H. Neff,E. Costa +1 more
TL;DR: It is demonstrated that the elevation of brain and heart-catecholamine levels is accompanied by a substantial reduction of the synthesis of these amines; this may be the result of inhibition of tyrosine hydroxylase by the increased concentrations of catecholamines.
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Turnover of 5-hydroxytryptamine (serotonin) in tissues.
TL;DR: Although amounts of serotonin in brain were too small to permit isotopic measurement it was possible to estimate its turnover from the increase following administration of harmaline, an inhibitor of serotonin metabolism, and such estimates indicate a half-life in brain of the order of minutes.