Cellular and Molecular Changes in Orthodontic Tooth Movement
Shahrul Hisham Zainal Ariffin,Zulham Yamamoto,lntan Zarina Zainol Abidin,Rohaya Megat Abdul Wahab,Zaidah Zainal Ariffin +4 more
TLDR
The involvement of stem cells and their development towards osteoblasts and osteoclasts during orthodontic treatment have been explained and several possible biomarkers representing these biological changes during specific phenomenon, that is, bone remodelling, inflammation, and root resorption have been proposed.Abstract:
Tooth movement induced by orthodontic treatment can cause sequential reactions involving the periodontal tissue and alveolar bone, resulting in the release of numerous substances from the dental tissues and surrounding structures. To better understand the biological processes involved in orthodontic treatment, improve treatment, and reduce adverse side effects, several of these substances have been proposed as biomarkers. Potential biological markers can be collected from different tissue samples, and suitable sampling is important to accurately reflect biological processes. This paper covers the tissue changes that are involved during orthodontic tooth movement such as at compression region (involving osteoblasts), tension region (involving osteoclasts), dental root, and pulp tissues. Besides, the involvement of stem cells and their development towards osteoblasts and osteoclasts during orthodontic treatment have also been explained. Several possible biomarkers representing these biological changes during specific phenomenon, that is, bone remodelling (formation and resorption), inflammation, and root resorption have also been proposed. The knowledge of these biomarkers could be used in accelerating orthodontic treatment.read more
Citations
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Journal ArticleDOI
Association of orthodontic force system and root resorption: A systematic review
TL;DR: It seems that positive correlations exist between increased force levels and increased root resorption, as well as between increased treatment time and increased Root Resorption.
Journal ArticleDOI
Biomarkers of Periodontal Tissue Remodeling during Orthodontic Tooth Movement in Mice and Men: Overview and Clinical Relevance
Fabrizia d’Apuzzo,Salvatore Cappabianca,Domenico Ciavarella,A. Monsurrò,Armando Silvestrini-Biavati,Letizia Perillo +5 more
TL;DR: The data suggest that knowledge of the remodeling process occurring in periodontal tissues during orthodontic and orthopedic therapies may be a clinical usefulness procedure leading to proper choice of mechanical stress to improve and to shorten the period of treatment, avoiding adverse consequences.
Book ChapterDOI
Periodontal Ligament and Alveolar Bone in Health and Adaptation: Tooth Movement
Nan Jiang,Weihua Guo,Mo Chen,Ying Zheng,Jian Zhou,Sahng G. Kim,Mildred C. Embree,Karen Songhee Song,Heloisa Fonseca Marão,Jeremy J. Mao +9 more
TL;DR: This chapter will discuss the biology of not only mature cells and their matrices in the periodontal ligament and alveolar bone, but also stem/progenitor cells that differentiate into fibroblasts, osteoblasts and osteoclasts.
Journal ArticleDOI
Non-surgical adjunctive interventions for accelerating tooth movement in patients undergoing fixed orthodontic treatment.
TL;DR: The effect of non-surgical adjunctive interventions on the rate of orthodontic tooth movement and the overall duration of treatment was assessed and two studies, involving a total of 111 participants, compared the use of Tooth Masseuse and OrthoAccel with conventional treatment mechanics during orthodentic alignment and canine retraction phases.
Journal ArticleDOI
MicroRNA-195-5p Regulates Osteogenic Differentiation of Periodontal Ligament Cells Under Mechanical Loading.
TL;DR: These findings are the first to demonstrate that miR‐195‐5p is a mechanosensitive gene that plays an important role in mechanical loading‐induced osteogenic differentiation and bone formation.
References
More filters
Journal ArticleDOI
An overview of the immune system.
Jacqueline Parkin,Bryony Cohen +1 more
TL;DR: In this review, the normal function of the immune system in recognising, repelling, and eradicating pathogens and other foreign molecules is covered.
Journal ArticleDOI
Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.
Kyeong-Sook Lee,Hyun-Jung Kim,Qing-Lin Li,Xin-Zi Chi,Chisato Ueta,Toshihisa Komori,John M. Wozney,Eung-Gook Kim,Je-Young Choi,Hyun-Mo Ryoo,Suk-Chul Bae +10 more
TL;DR: The results indicate that Runx 2 is a major target gene shared by TGF-β and BMP signaling pathways and that the coordinated action of Runx2 and B MP-activated Smads leads to the induction of osteoblast-specific gene expression in C2C12 cells.
Journal ArticleDOI
Cellular, molecular, and tissue-level reactions to orthodontic force
Vinod Krishnan,Zeev Davidovitch +1 more
TL;DR: This review is organized to include all major findings from the beginning of research in the biology of tooth movement, highlights recent developments in cellular, molecular, tissue, and genetic reactions in response to orthodontic force application, and provides insight into the biological background of various deleterious effects of orthodentic forces.
Journal ArticleDOI
Mechanisms of Tooth Eruption and Orthodontic Tooth Movement
Gary E. Wise,Gregory J. King +1 more
TL;DR: A better appreciation of the molecular and cellular events that regulate osteoclastogenesis and osteogenesis in eruption and orthodontics is not only central to understanding of how these processes occur, but also is needed for ultimate development of the means to control them.
Journal ArticleDOI
The complexities of skeletal biology.
TL;DR: For a long time, the skeleton was seen as an amorphous tissue of little biological interest, but this view ignored the large number of genetic and degenerative diseases affecting this organ.
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