Journal ArticleDOI
Cellular DNA content as a marker of neoplasia in man.
Barthel Barlogie,Benjamin Drewinko,J. Schumann,Wolfgang Göhde,Gary M. Dosik,Jean Latreille,Dennis A. Johnston,Emil J. Freireich +7 more
TLDR
It is concluded that flow cytometry of cellular DNA content is a rapid, objective, quantitative and sensitive method to determine a highly specific and stable tumor cell marker.About:
This article is published in The American Journal of Medicine.The article was published on 1980-08-01. It has received 303 citations till now. The article focuses on the topics: Hyperdiploidy.read more
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The 5-methylcytosine content of DNA from human tumors
Miguel A. Gama-Sosa,Valerie A. Slagel,Ronald W. Trewyn,Ronald Oxenhandler,Kenneth C. Kuo,Charles W. Gehrke,Melanie Ehrlich +6 more
TL;DR: Most of the metastatic neoplasms had significantly lower genomic m5C contents than did most of the benign neoplasm or normal tissues, which might reflect an involvement of extensive demethylation of DNA in tumor progression.
Journal Article
Flow Cytometry in Clinical Cancer Research
Barthel Barlogie,Martin N. Raber,J. Schumann,Tod S. Johnson,Benjamin Drewinko,Douglas E. Swartzendruber,Wolfgang Göhde,Michael Andreeff,Emil J. Freireich +8 more
TL;DR: A role for flow cytometry is emerging as a tool for diagnosis of cancer (abnormal DNA content), specific histopathological diagnosis (RNA for hematological cancers; surface markers for lymphoid and myeloid neoplasms), prognosis, and treatment (cytokinetically oriented, monoclonal antibodies, drug pharmacology).
Journal Article
Centrosome Defects and Genetic Instability in Malignant Tumors
German Pihan,Aruna Purohit,Janice Wallace,Hans Knecht,Bruce A. Woda,Peter J. Quesenberry,Stephen J. Doxsey +6 more
TL;DR: Centrosomes in nearly all tumors and tumor-derived cell lines were atypical in shape, size, and composition and were often present in multiple copies, suggesting they may contribute to genetic instability in cancer.
Journal ArticleDOI
Cellular DNA content as a predictor of response to chemotherapy in infants with unresectable neuroblastoma
TL;DR: It is concluded that in neuroblastoma of infants, hyperdiploidy of tumor cells is associated with a better response to chemotherapy than is diploidsy.
Journal ArticleDOI
Clinical and biological significance of aneuploidy in human tumours.
TL;DR: The accumulating evidence that tumour ploidy reflects the biological behaviour of a large number of tumour types and that diploid tumours in particular have a relatively good prognosis is reviewed.
References
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Journal ArticleDOI
Pattern Classification and Scene Analysis.
Book
Pattern classification and scene analysis
Richard O. Duda,Peter E. Hart +1 more
TL;DR: In this article, a unified, comprehensive and up-to-date treatment of both statistical and descriptive methods for pattern recognition is provided, including Bayesian decision theory, supervised and unsupervised learning, nonparametric techniques, discriminant analysis, clustering, preprosessing of pictorial data, spatial filtering, shape description techniques, perspective transformations, projective invariants, linguistic procedures, and artificial intelligence techniques for scene analysis.
Journal ArticleDOI
A clustering technique for summarizing multivariate data.
Geoffrey H. Ball,David J. Hall +1 more
TL;DR: A practical computing method termed ISODATA, which finds the cluster structure of such data, is described and provides a fit to the data of a set of cluster centers that tends to minimize the sum of the squared distances of each data point from its closest cluster center.
Book
Flow cytometry and sorting
TL;DR: Cytophysical Methods Cell Preparation Cytochemical Methods Analysis of Measurements Cell Biology Hematology and Immunology Applications in Oncology Index.