Cellular sites of immunologic unresponsiveness.
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The reconstitution of the immune response of lethally irradiated mice to human gamma-globulin is dependent on the synergistic action of bone marrow with thymus cells, but neither bone marrow nor thymUS cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.Abstract:
The reconstitution of the immune response of lethally irradiated mice to human γ-globulin is dependent on the synergistic action of bone marrow with thymus cells. Immunologic unresponsiveness appears to involve a functional defect at each of these cellular levels, inasmuch as neither bone marrow nor thymus cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.read more
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Book ChapterDOI
Thymus-Dependent (T) Cell Competence in Chronic LCM Virus Infection
TL;DR: While observing immunopathological and virological events in chronically infected mice, a picture of antigen, IgG and C3 deposits had been seen many times before in different diseases and is pathognomonic of immune complex deposits, which suggested that these mice, in spite of carrying persistent titers of LCM virus, were also mounting an anti-viral antibody response.
Journal ArticleDOI
Tolerogen-mediated suppression of the immune response. Suppressor cells as passive transfer agents.
TL;DR: The doses and experimental procedures used were comparable to those commonly used for suppressor cell generation and assay, and it is suggested that antigen‐specific suppressor cells may produce their effects through passive transfer of antigen and/or tolerogen.
Book ChapterDOI
Immunological Phenomena in Rheumatoid Arthritis
TL;DR: This chapter explores the immunological phenomena in rheumatoid arthritis and shows the inhibition of Gm agglutination reactions and the demonstration of some r heumatoid factor specificities hidden by complexing with autologous IgG.
Journal ArticleDOI
Hapten-carrier relationships in immunological unresponsiveness
Ilkka Seppälä,Olli Mäkelä +1 more
TL;DR: The responses of the paralyzed mice relative to control mice are given below in a simplified form.
Journal ArticleDOI
Selection, memory and selective memories: T cells, B cells and Sir Mac 1968
TL;DR: In 1968, Sir MacFarlane Burnet postulated that both T and B cells have antigenic specificity in the Miller and Mitchell system and that B-cell production of antibody is influenced by nonspecific pharmacologically active substances elaborated by responding T cells.
References
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Journal ArticleDOI
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.
TL;DR: The results were considered to support the concept that memory resides in the T cell population and that collaboration between T and B cells is necessary for an optimal secondary antibody response.
Journal ArticleDOI
A Requirement for Two Cell Types for Antibody Formation in vitro
TL;DR: It was found that both adherent and nonadherent cells were necessary for the induction of antibody formation to sheep red blood cells in vitro.
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Thymus-Marrow Cell Combinations. Synergism in Antibody Production.∗:
TL;DR: Suspensions containing normal thymus, spleen, or marrow cells were injected into irradiated syngeneic mice which were subsequently given antigen and mice receiving both marrow and thymUS cells produced more centers of hemolytic activity in their spleens than mice receiving cells of either type alone.
Journal ArticleDOI
Antibody formation in vitro.
TL;DR: The results are discussed in terms of a possible mechanism of antibody production in which an RNAse-sensitive substance resulting from the interaction of macrophages and antigen is capable of stimulating antibody synthesis in lymphocytic cells.
Journal Article
A Modification of the Hemolytic Plaque Assay for Use with Protein Antigens
TL;DR: The method is simple and sensitive and the results mimic the kinetics of the response that is seen in in vivo assays of serum antibody.