Cellular sites of immunologic unresponsiveness.
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The reconstitution of the immune response of lethally irradiated mice to human gamma-globulin is dependent on the synergistic action of bone marrow with thymus cells, but neither bone marrow nor thymUS cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.Abstract:
The reconstitution of the immune response of lethally irradiated mice to human γ-globulin is dependent on the synergistic action of bone marrow with thymus cells. Immunologic unresponsiveness appears to involve a functional defect at each of these cellular levels, inasmuch as neither bone marrow nor thymus cells from unresponsive donors are capable of demonstrating synergism in combination with their normal counterpart.read more
Citations
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Journal ArticleDOI
Molecular mechanisms for B lymphocyte selection: induction and regulation of antigen-receptor-mediated apoptosis of mature B cells in normal mice and their defect in autoimmunity-prone mice
TL;DR: It is found that strong crosslinking of sIg induces apoptosis of mature B cells, suggesting that interaction with membrane-bound self-antigens may eliminate self-reactive mature B Cells by apoptosis.
BookDOI
Immunology of Neuromuscular Disease
TL;DR: Immunological self-tolerance and autoimmunity, H.W.Wekerle Neuropathies associated with anti-myelin antibodies, D.D. Steck Guillain-Barre syndrome and CIDP, and Peripheral neuropathy due to vasculitis: immunopathogenesis, clinical features and treatment.
Journal ArticleDOI
The role of thymocytes and bone marrow cells in defining the response to the dinitrophenyl hapten attached to positively and negatively charged synthetic polypeptide carriers. Cell fractionation over charged columns.
TL;DR: Findings indicate that it is possible to distinguish between thymocytes on the basis of their capacity to react with more acidic or more basic surfaces and that a population of thymus-derived cells may recognize immunogens on the based of their overall electrical charge.
Book ChapterDOI
Studies on the Influence of T Cells in Antibody Production
Graham F. Mitchell,Graham F. Mitchell,R. I. Mishell,R. I. Mishell,L A Herzenberg,L A Herzenberg +5 more
TL;DR: In this article, the influence of T cells in antibody production was discussed, focusing on theta alloantigen as a marker for T cells, and influence of treatment with anti-theta on the in vitro response of spleen cells from neonatally thymectomized mice to SRBC.
Book ChapterDOI
Antigen-receptor interactions in the induction of B-lymphocyte unresponsiveness.
TL;DR: In the past decade it has been established that antigen-reactive cells are lymphocytes and can be divided into two distinct functional classes, which exert important regulatory influences on thymus-independent (bone marrow-derived) B-lymphocytes, which are the direct precursors of antibody-forming cells (AFC).
References
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Journal ArticleDOI
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.
TL;DR: The results were considered to support the concept that memory resides in the T cell population and that collaboration between T and B cells is necessary for an optimal secondary antibody response.
Journal ArticleDOI
A Requirement for Two Cell Types for Antibody Formation in vitro
TL;DR: It was found that both adherent and nonadherent cells were necessary for the induction of antibody formation to sheep red blood cells in vitro.
Journal ArticleDOI
Thymus-Marrow Cell Combinations. Synergism in Antibody Production.∗:
TL;DR: Suspensions containing normal thymus, spleen, or marrow cells were injected into irradiated syngeneic mice which were subsequently given antigen and mice receiving both marrow and thymUS cells produced more centers of hemolytic activity in their spleens than mice receiving cells of either type alone.
Journal ArticleDOI
Antibody formation in vitro.
TL;DR: The results are discussed in terms of a possible mechanism of antibody production in which an RNAse-sensitive substance resulting from the interaction of macrophages and antigen is capable of stimulating antibody synthesis in lymphocytic cells.
Journal Article
A Modification of the Hemolytic Plaque Assay for Use with Protein Antigens
TL;DR: The method is simple and sensitive and the results mimic the kinetics of the response that is seen in in vivo assays of serum antibody.