Chagas disease in European countries: the challenge of a surveillance system
Luca Basile,J M Jansa,Yves Carlier,D D Salamanca,Andrea Angheben,Alessandro Bartoloni,Jorge Seixas,T. van Gool,Carmen Cañavate,María Flores-Chávez,Yves-Laurent Julien Jackson,Peter L. Chiodini,Pedro Albajar-Viñas +12 more
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TLDR
Urgent measures need to be taken to detect new cases of congenital transmission and take care of the existing cases with a focus on migrants without legal residency permit and potential difficulty accessing care.Abstract:
A study of aggregate data collected from the literature and official sources was undertaken to estimate expected and observed prevalence of Trypanosoma cruzi infection, annual incidence of congenital transmission and rate of underdiagnosis of Chagas disease among Latin American migrants in the nine European countries with the highest prevalence of Chagas disease. Formal and informal data sources were used to estimate the population from endemic countries resident in Europe in 2009, diagnosed cases of Chagas disease and births from mothers originating from endemic countries. By 2009, 4,290 cases had been diagnosed in Europe, compared with an estimated 68,000 to 122,000 expected cases. The expected prevalence was very high in undocumented migrants (on average 45% of total expected cases) while the observed prevalence rate was 1.3 cases per 1,000 resident migrants from endemic countries. An estimated 20 to 183 babies with congenital Chagas disease are born annually in the study countries. The annual incidence rate of congenital transmission per 1,000 pregnancies in women from endemic countries was between none and three cases. The index of under diagnosis of T. cruzi infection was between 94% and 96%. Chagas disease is a public health challenge in the studied European countries. Urgent measures need to be taken to detect new cases of congenital transmission and take care of the existing cases with a focus on migrants without legal residency permit and potential difficulty accessing care.read more
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Global economic burden of Chagas disease: a computational simulation model.
Bruce Y. Lee,Kristina M. Bacon,Maria Elena Bottazzi,Maria Elena Bottazzi,Peter J. Hotez,Peter J. Hotez +5 more
TL;DR: The economic burden of Chagas disease is similar to or exceeds those of other prominent diseases globally (eg, rotavirus $2·0 billion, cervical cancer $4·7 billion) even in the USA, where the disease has not been traditionally endemic, suggesting an economic argument for more attention and efforts towards control.
Journal ArticleDOI
Chagas Disease: From Discovery to a Worldwide Health Problem
Kárita Cláudia Freitas Lidani,Fabiana Antunes Andrade,Lorena Bavia,Flávia Silva Damasceno,Marcia Holsbach Beltrame,Iara Messias-Reason,Thaisa Lucas Sandri,Thaisa Lucas Sandri +7 more
TL;DR: This review aims to describe the spread of CD cases worldwide since its discovery until it has become a global public health concern.
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Diagnosis and management of Chagas disease and cardiomyopathy.
Antonio Luiz Pinho Ribeiro,Maria do Carmo Pereira Nunes,Mauro M. Teixeira,Manoel Otávio da Costa Rocha +3 more
TL;DR: Clinical presentation varies widely according to the extent of myocardial damage, and manifests mainly as three basic syndromes that can coexist in an individual patient: heart failure, cardiac arrhythmia, and thromboembolism.
Journal ArticleDOI
Prevalence of Chagas disease in Latin-American migrants living in Europe: a systematic review and meta-analysis.
Ana Requena-Méndez,Edelweiss Aldasoro,Elisa de Lazzari,Elisa Sicuri,Michael Brown,David Moore,Joaquim Gascon,Jose Muñoz +7 more
TL;DR: Prevalence of Chagas in LA migrants living in Europe is high, particularly in migrants from Bolivia and Paraguay, and prevalence estimates should be used to estimate the burden of disease in European countries.
Journal ArticleDOI
Bioluminescence imaging of chronic Trypanosoma cruzi infections reveals tissue‐specific parasite dynamics and heart disease in the absence of locally persistent infection
Michael D. Lewis,Amanda F. Francisco,Martin C. Taylor,Hollie Burrell-Saward,Alex P. McLatchie,Michael A. Miles,John M. Kelly +6 more
TL;DR: The gut is identified as a permissive niche for long‐term T. cruzi infection and canonical features of Chagas disease can occur without continual myocardium‐specific infection, as shown in mice infected with Chronically infected mice.
References
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Journal ArticleDOI
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Journal ArticleDOI
Prevalence and vertical transmission of Trypanosoma cruzi infection among pregnant Latin American women attending 2 maternity clinics in Barcelona, Spain.
Jose Muñoz,Oriol Coll,Teresa Juncosa,Mireia Vergés,Marta del Pino,Victoria Fumadó,Jordi Bosch,Elizabeth Posada,Sara Hernandez,Roser Fisa,Josep Maria Boguña,Montserrat Gállego,Sergi Sanz,Montserrat Portús,Joaquim Gascon +14 more
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Maria Piron,Mireia Vergés,Jose Muñoz,Natalia Casamitjana,Sergi Sanz,Rosa María Maymó,José Manuel Hernández,Lluís Puig,Montserrat Portús,Joaquim Gascon,Silvia Sauleda +10 more
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