Journal ArticleDOI
Changes in synaptic potential properties during acetylcholine receptor accumulation and neurospecific interactions in Xenopus nerve-muscle cell culture.
TLDR
In nerve-contacted muscle cells where spontaneous synaptic activity could not be detected, extensive acetylcholine receptor accumulation was not found at sites of nerve contact and the presence of miniature endplate potentials were strongly correlated.About:
This article is published in Developmental Biology.The article was published on 1980-08-01. It has received 124 citations till now. The article focuses on the topics: Acetylcholine receptor & Neuromuscular junction.read more
Citations
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Journal ArticleDOI
Developmental regulation of nicotinic acetylcholine receptors.
S M Schuetze,Lorna W. Role +1 more
Journal ArticleDOI
Neurotrophins promote maturation of developing neuromuscular synapses.
Ti Wang,Kewei Xie,Bai Lu +2 more
TL;DR: Results suggest that BDNF and NT- 3 promote functional maturation of synapses in Xenopus nerve-muscle cocultures, primarily through a presynaptic mechanism.
Journal ArticleDOI
Aggregates of acetylcholine receptors are associated with plaques of a basal lamina heparan sulfate proteoglycan on the surface of skeletal muscle fibers.
M J Anderson,D M Fambrough +1 more
TL;DR: In this article, hybridoma techniques have been used to generate monoclonal antibodies to an antigen concentrated in the basal lamina at the Xenopus laevis neuromuscular junction.
Journal ArticleDOI
The perinatal reorganization of the innervation of skeletal muscle in mammals.
J.K.S. Jansen,T. Fladby +1 more
TL;DR: The perinatal reorganization of muscle innervation is executed in a setting established by the earlier embryonic developmental processes, leading to the generation of a stereotyped set of skeletal muscles, each innervated in an orderly fashion from an appropriate pool of spinal motoneurons.
Journal ArticleDOI
Expression of a Putative Vesicular Acetylcholine Transporter Facilitates Quantal Transmitter Packaging
Hongjun Song,Guo Li Ming,Edward A. Fon,Elizabeth E. Bellocchio,Robert H. Edwards,Mu-ming Poo +5 more
TL;DR: A putative vesicular acetylcholine transporter (VAChT) was overexpressed in developing Xenopus spinal neurons by injection of rat VAChT cDNA or synthetic mRNA into Xenopus embryos.
References
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Journal ArticleDOI
The binding of acetylcholine to receptors and its removal from the synaptic cleft
Bernard Katz,Ricardo Miledi +1 more
TL;DR: Acetylcholine noise and miniature end‐plate potentials were recorded with focal external micro‐electrodes to study the response of ACh to EMT in EMT‐naïve mice.
Journal ArticleDOI
The formation of synapses in striated muscle during development.
Max R. Bennett,A. G. Pettigrew +1 more
TL;DR: A study has been made of the formation of synapses in developing striated muscles which receive either a focal (the rat hemidiaphragm) or a distributed innervation using histological, ultrastructural and electrophysiological techniques.
Journal ArticleDOI
Nerve-induced and spontaneous redistribution of acetylcholine receptors on cultured muscle cells.
M J Anderson,M W Cohen +1 more
TL;DR: It is concluded that ACh receptors aggregate within the sarcolemma, spontaneously as well as in response to innervation, thereby contributing to the development of high receptor density in the subneural muscle membrane.
Journal ArticleDOI
Synapse formation between dissociated nerve and muscle cells in low density cell cultures
TL;DR: Some of the neurons dissociated from embryonic chick spinal cord and maintained in low density cell cultures establish functional contacts with muscle fibers that had formed in vitro from previously plated myoblasts.
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Nerve-induced and spontaneous redistribution of acetylcholine receptors on cultured muscle cells.
M J Anderson,M W Cohen +1 more