Journal ArticleDOI
Changes in tumor oxygenation during combined treatment with split-course radiotherapy and chemotherapy in patients with head and neck cancer
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TLDR
The decrease in the tumor oxygenation status at doses of 30 and 70 Gy are important findings because they are in contrast to the concept of continuous improvement of the oxygenationstatus during fractionated radiotherapy.About:
This article is published in Radiotherapy and Oncology.The article was published on 1998-08-01. It has received 64 citations till now. The article focuses on the topics: Tumor Oxygenation & Dose fractionation.read more
Citations
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Journal ArticleDOI
Detection and characterization of tumor hypoxia using pO2 histography.
TL;DR: Identification of tumor hypoxia may allow an assessment of a tumor's potential to develop an aggressive phenotype or acquired treatment resistance, both of which lead to poor prognosis.
Journal ArticleDOI
Radiation-induced vascular damage in tumors: implications of vascular damage in ablative hypofractionated radiotherapy (SBRT and SRS).
Heon Joo Park,Robert J. Griffin,Susanta K. Hui,Seymour H. Levitt,Seymour H. Levitt,Chang W. Song +5 more
TL;DR: The results for experimental tumors strongly indicate that SBRT or SRS of human tumors with doses higher than about 10 Gy/fraction is likely to induce considerable vascular damages and thereby damages the intratumor microenvironment, leading to indirect tumor cell death.
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Impact of Tumor Hypoxia and Anemia on Radiation Therapy Outcomes
TL;DR: A review of the literature reveals that a low hemoglobin level before or during radiation therapy is an important risk factor for poor locoregional disease control and survival, implying that a strong correlation could exist between anemia and hypoxia (ultimately predicting for a poor outcome).
Journal ArticleDOI
Microenvironment-induced cancer metastasis.
TL;DR: Clinical data suggesting that cancer metastasis may be induced by the microenvironment of the primary tumour is presented and possible mechanisms of microenvironment-induced metastasis are discussed, based on a critical review of relevant data from studies of experimental tumours and cells in culture.
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Exploratory prospective trial of hypoxia-specific PET imaging during radiochemotherapy in patients with locally advanced head-and-neck cancer
Daniel Zips,Klaus Zöphel,Nasreddin Abolmaali,Rosalind Perrin,Andrij Abramyuk,Robert Haase,Steffen Appold,Jörg Steinbach,Jörg Kotzerke,Michael Baumann +9 more
TL;DR: It is demonstrated that FMISO-PET/CT imaging during the initial phase of treatment carries strong prognostic value and could be promising way to select patients that would benefit from hypoxia modification or dose-escalated treatment.
References
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Journal ArticleDOI
The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy
TL;DR: Consideration is given to the supply of oxygen to tissues as a factor in radiotherapy, and it is concluded that in certain circumstances the effectiveness of X-ray treatment might be increased if the patient were breathing oxygen at the time of irradiation.
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Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
TL;DR: Tumor hypoxia adversely affected the prognosis of patients in this study and understanding of the mechanistic relationship between Hypoxia and treatment outcome will allow the development of new and rational treatment programs in the future.
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Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
TL;DR: Results suggest that pretreatment tumor oxygenation status is predictive of radiation response, when using the fraction of pO2 values less than 2.5 mmHg as endpoint.
Journal Article
Oxygenation of Human Tumors: Evaluation of Tissue Oxygen Distribution in Breast Cancers by Computerized O2 Tension Measurements
TL;DR: The oxygenation pattern in breast cancers and the occurrence of hypoxia and/or anoxia did not correlate with either the pathological stages and histological grades or with a series of clinically relevant parameters.
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Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy.
Robert A. Gatenby,Howard Kessler,Jay S. Rosenblum,Lawrence R. Coia,Philip J. Moldofsky,William H. Hartz,George J. Broder +6 more
TL;DR: Oxygen distribution was measured in 31 fixed lymph node metastases from squamous cell carcinoma of the head and neck by passing a needle electrode through each tumor under CT guidance to suggest that oxygen plays a significant role in human tumor response to radiation therapy.