Journal ArticleDOI
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
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Results suggest that pretreatment tumor oxygenation status is predictive of radiation response, when using the fraction of pO2 values less than 2.5 mmHg as endpoint.About:
This article is published in Radiotherapy and Oncology.The article was published on 1996-01-01. It has received 993 citations till now. The article focuses on the topics: Tumor Oxygenation & Primary tumor.read more
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Journal ArticleDOI
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.
Michael Höckel,Peter Vaupel +1 more
TL;DR: Because malignant tumors no longer execute functions necessary for homeostasis (such as the production of adequate amounts of adenosine triphosphate), the physiology-based definitions of the term "hypoxia" are not necessarily valid for malignant tumor patients.
Journal ArticleDOI
Exploiting tumour hypoxia in cancer treatment.
TL;DR: Solid tumours contain regions at very low oxygen concentrations (hypoxia), often surrounding areas of necrosis, which provides an opportunity for tumour-selective therapy, including prodrugs activated by Hypoxia, hypoxia-specific gene therapy, targeting the hypoxIA-inducible factor 1 transcription factor, and recombinant anaerobic bacteria.
Journal Article
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy
Janice M. Brown,Amato J. Giaccia +1 more
TL;DR: Four areas that are under active investigation of hypoxia-selective cytotoxins take advantage of the unique low oxygen tension in the majority of human solid tumors, and attempts to use gene therapy activated either by the low oxygen environment or by necrotic regions of tumors are discussed.
Journal ArticleDOI
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.
Patrick H. Maxwell,Gabi U. Dachs,Jonathan M. Gleadle,Lynn G. Nicholls,Adrian L. Harris,Ian J. Stratford,Oliver Hankinson,Christopher W. Pugh,Peter J. Ratcliffe +8 more
TL;DR: Findings show that HIF-1 activation occurs in hypoxic regions of tumors and demonstrate a major influence on gene expression, tumor angiogenesis, and growth.
Journal ArticleDOI
Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study
Marianne Nordsmark,Søren M. Bentzen,Volker Rudat,David M. Brizel,Eric Lartigau,Peter Stadler,Axel Becker,Markus Adam,Michael Molls,Juergen Dunst,David J. Terris,Jens Overgaard +11 more
TL;DR: Evidence is provided that tumor hypoxia is associated with a poor prognosis in patients with advanced head and neck cancer.
References
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BookDOI
TNM classification of malignant tumours
TL;DR: Head and Neck Tumours.- Lip and Oral Cavity.- Pharynx.- Larynx.' Maxillary Sinus.- Salivary Glands.- Thyroid Gland.- Digestive System Tumour .
Journal ArticleDOI
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
Thomas G. Graeber,Cynthia Osmanian,Tyler Jacks,David E. Housman,Cameron J. Koch,Scott W. Lowe,Scott W. Lowe,Amato J. Giaccia +7 more
TL;DR: It is proposed that hypoxia provides a physiological selective pressure in tumours for the expansion of variants that have lost their apoptotic potential, and in particular for cells acquiring p53mutations.
Journal ArticleDOI
The Concentration of Oxygen Dissolved in Tissues at the Time of Irradiation as a Factor in Radiotherapy
TL;DR: Consideration is given to the supply of oxygen to tissues as a factor in radiotherapy, and it is concluded that in certain circumstances the effectiveness of X-ray treatment might be increased if the patient were breathing oxygen at the time of irradiation.
Journal Article
Oxygenation of Human Tumors: Evaluation of Tissue Oxygen Distribution in Breast Cancers by Computerized O2 Tension Measurements
TL;DR: The oxygenation pattern in breast cancers and the occurrence of hypoxia and/or anoxia did not correlate with either the pathological stages and histological grades or with a series of clinically relevant parameters.
Journal ArticleDOI
Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy.
Robert A. Gatenby,Howard Kessler,Jay S. Rosenblum,Lawrence R. Coia,Philip J. Moldofsky,William H. Hartz,George J. Broder +6 more
TL;DR: Oxygen distribution was measured in 31 fixed lymph node metastases from squamous cell carcinoma of the head and neck by passing a needle electrode through each tumor under CT guidance to suggest that oxygen plays a significant role in human tumor response to radiation therapy.