Showing papers in "Radiotherapy and Oncology in 1993"

TL;DR: Preliminary results suggest that tumor oxygenation as determined with this standardized procedure appears to be a new independent prognostic factor influencing survival in advanced cancer of the uterine cervix.

TL;DR: This paper contains the definition and scoring for each type of complication, general guidelines for their use, and the rationale of the glossary leaves it open for as yet undescribed types of complications.

TL;DR: It is concluded that limited surgery and radiotherapy achieve excellent long-term tumour control and survival with low morbidity.

TL;DR: The purpose of this study was to establish which level of geometrical accuracy can be obtained during radiotherapy, using portal image analysis, with a minimum number of patient set-up measurements and corrections, using a computer simulation.

TL;DR: The details of a practical implementation of a model for the prediction of the tumor control probability (TCP) when a tumor is irradiated non-uniformly are presented and how to derive the model parameters from clinically available data are shown.

TL;DR: Radiosurgery is a safe and effective treatment for acoustic neuromas with acceptable morbidity that may be lowered by the use of multiple isocenter treatment techniques and by earlier treatment of small tumors.

TL;DR: Levels of glial fibrillary acidic protein (GFAP), which is a marker for astrocytes, were measured by ELISA in irradiated brains taken at varying time points after irradiation and there was an increase in the number and the intensity of microglial cell staining for Mac I antigen.

TL;DR: In the present population, psychological distress is related to pain and reduced performance status, and cases at risk must be identified.

TL;DR: Pediatric patients treated for primary disease showed improved survival over those treated for recurrence over adults and appeared to be due to treatment toxicity, while surgical morbidity correlated with extent of surgery.

TL;DR: The results of the present study on brain tumours demonstrate that the subjective interpretation of the tumour extent based on CT images might be one of the largest factors contributing to the overall uncertainty in radiation treatment planning.

TL;DR: Diarrhea and nausea were the most frequent early reactions and were ameliorated by limiting the duration of chemotherapy to 5 days/week and by using XRT techniques to exclude the small bowel from the radiation portal.

TL;DR: The worldwide collection of control data for head and neck tumours presented by Withers et al. was reanalysed using a model which includes an explicit lag phase before the onset of tumour clonogen repopulation and a new feature of the methodology is the computation of profile-likelihood confidence limits.

TL;DR: A biologically based model is developed for normal tissue complication probability as a function of dose and irradiated volume fraction for organs such as the kidney and the lung.

TL;DR: It can be concluded that for treatments requiring a high level of precision, portal images should be made and analyzed during the whole treatment course in order to detect and correct significant time trends.

TL;DR: In 216 patients with brain metastases two schedules of brain irradiation were compared in a randomized trial: one course of 18 Gy/3 fractions/3 days versus the same fractionation followed by a second course of radiotherapy with a one-month time interval.

TL;DR: It is suggested that carbogen breathing increases tumor oxygenation as assessed by polarography, and the breathing time appears to be important for therapeutical use and should to be taken into consideration.

TL;DR: The long-term results from a randomized trial of pre- or postoperative megavoltage radiation therapy versus surgery alone in pre- and postmenopausal women with operable breast cancer suggest that local undertreatment may be deleterious in subgroups of patients.

TL;DR: An evaluation of the precision and accuracy of the head fixation system, which was performed with a photogrammetry system, is presented.

TL;DR: Fractionated SRT is a noninvasive form of localised radiation which may be a suitable alternative to interstitial therapy in this group of patients with recurrent glioma.

TL;DR: The administration of high radiation doses may increase the disease-free interval in the treatment of chordoma, and the objective response and dose-response relationships were analyzed.

TL;DR: Investigation of dose dependency and effective period of suppressive effects by low dose total body irradiation in both artificial and spontaneous lung metastasis suggest that careful assessment of effective dose and duration of low dose TBI on human metastasis could provide a new therapy to suppress clinical metastasis.

TL;DR: The life expectancy for those presenting with advanced (stage III/IV) disease was very poor with a low complete remission rate from chemotherapy, and the salvage rate from recurrent disease was poor.

TL;DR: Doses of nicotinamide that can be tolerated clinically should produce adequate enhancements of radiation damage in human tumours, although the elimination half-lives were not dose-dependent.

TL;DR: CDF1 mice were allowed to breathe either oxygen, carbogen or different concentrations of carbon monoxide gas and these treatments significantly altered the percentage of clonogenic hypoxic cells in a C3H mouse mammary carcinoma and these changes were found to correlate with direct measurements of tumour oxygenation obtained using an Eppendorf pO2 electrode.

TL;DR: The results indicate that the combined use of SPECT and CT information is an effective method for determining dose-effect relations for regional lung function parameters in each individual patient.

TL;DR: It is concluded that irregularly shaped tumours suitable for stereotactic radiotherapy with a linear accelerator are better treated with conformal static non-coplanar beams rather than with the multiple arc technique.

TL;DR: In Hemangioma patients, radiotherapy has been reported to give good results with minor morbidity, suspending the tumor growth and decreasing the symptomatology, and improvement of the quality of life was observed in all patients.

TL;DR: High-precision radiotherapy as it is performed in Heidelberg can be regarded as an effective, reliable and tolerable system for selected tumors of the head and neck.

TL;DR: Dose-response charts have been constructed to determine the tumouricidal dose for differentiated thyroid carcinoma metastases and thus enable precise activities of radioiodine to be prescribed in order to maximise tumour kill and minimise morbidity.

TL;DR: The preliminary results from this exit dosimetry technique demonstrate that, under specific conditions, doses can be determined to within 2.5% of that measured using silicon diodes or ion chambers.