Chemistry and biochemistry of B12

TLDR: This work has shown that Cobalamin Transport in Bacteria and Regulation of Adenosylcobalamin Biosynthesis in Salmonella typhimurium, and the Role of Corrinoids in Methanogenesis, are regulated by different mechanisms and require different approaches to be understood.

Abstract: CHEMISTRY OF B-12. B-12 History (H. Hogenkamp). X-ray Crystallography of B-12 (B. Krautler & C. Kratky). X-Ray Absorption Spectorscopy of B-12: Structural Changes of Intermediate States (M. Chance). Electronic Structure and Spectra of B-12: From Trans Effects to Protein Conformation I (J. Pratt). Electronic Structure and Spectra of B-12: From Trans Effects to Protein Conformation II (J. Pratt). EPR Spectroscopy of B-12-Dependent Enzymes (G. Gerfen). NMR Spectroscopy of B-12 (K. Brown). Vibrational Spectroscopy of B-12 and Related Compounds (L. Marzilli & S. Hirota). Magnetic Field Dependence of Cobalamin Photochemistry and Enzymes (C. Grissom). Stereospecificity of the Coenzyme B-12 Catalyzed Rearrangements and the Role of Negative Catalysis (J. Retey). Modeling the Structure of Cobalt Corrins by Molecular Mechanics and Molecular Dynamics Methods (H. Marques). B-12 Electrochemistry and Organometallic Electrochemical Synthesis (B. Krautler). BIOCHEMISTRY AND BIOLOGY OF B-12. B-12 and Nutrition (S. Stabler). Inborn Errors of Cobalamin Metabolism (D. Rosenblatt & W. Fenton). Diagnostic and Therapeutic Analogs of Cobalamin (H. Hogenkamp, et al.). Intrinsic Factor and Haptocorrin and Their Receptors (D. Alpers & G. Russell-Jones). Transcobalamin II (S. Rothenberg, et al.). Mammalian Receptors of Vitamin B-12-Binding Proteins (S. Moestrup & P. Verroust). Cobalamin Transport in Bacteria (C. Bradbeer). Biosynthesis of B-12 in the Aerobic Organism Pseudomonas denitrificans (A. Battersby & F. Leeper). B-12 Biosynthesis: The Anaerobic Pathway (A. Scott, et al.). Biosynthesis of the 5-6 Dimethylbenzimidazole Moiety of Cobalamin and of the Other Bases Found in Natural Corrinoids (P. Renz). Regulation of Adenosylcobalamin Biosynthesis in Salmonella typhimurium (J. Semerena). X-ray Crystallography of B-12 Enzymes: Methylmalonyl-CoA Mutase and Methionine Synthase (M. Ludwig & P. Evans). The Acetogenic Corriniod Proteins (S. Ragsdale). The Role of Corrinoids in Methanogenesis (K. Sauer & R. Thauer). Methionine Synthase (R. Matthews). Methylmalonyl-CoA Mutase (R. Banerjee & S. Chowdhury). Ribonucleotide Reductases (M. Fontecave & E. Mulliez). Glutamate Mutase and 2-Methyleneglutarate Mutase (W. Buckel, et al.). Diol Dehydrase and Glycerol Dehydrase (T. Toraya). Ethanolamine Ammonia-Lyase (V. Bandarian & G. Reed). Anomutases (P. Frey). Isobutyryl-CoA Mutase (K. Zerbe-Burkhardt, et al.). Reductive Dehalogenases (G. Wohlfarth & G. Diekert).