Journal ArticleDOI
Chlorogenic Acid and Synthetic Chlorogenic Acid Derivatives: Novel Inhibitors of Hepatic Glucose-6-phosphate Translocase.
Horst Hemmerle,Burger Hans-Joerg,Peter Below,Gerrit Schubert,Robert Rippel,Schindler Peter,Erich F. Paulus,Andreas W. Herling +7 more
TLDR
In this paper, chlorogenic acid was identified as a specific inhibitor of the glucose-6-phosphate translocase component of this enzyme system in microsomes of rat liver.Abstract:
The enzyme system glucose-6-phosphatase (EC 3.1.3.9) plays a major role in the homeostatic regulation of blood glucose. It is responsible for the formation of endogenous glucose originating from gluconeogenesis and glycogenolysis. Recently, chlorogenic acid was identified as a specific inhibitor of the glucose-6-phosphate translocase component (Gl-6-P translocase) of this enzyme system in microsomes of rat liver. Glucose 6-phosphate hydrolysis was determined in the presence of chlorogenic acid or of new synthesized derivatives in intact rat liver microsomes in order to assess the inhibitory potency of the compounds on the translocase component. Variation in the 3-position of chlorogenic acid had only poor effects on inhibitory potency. Introduction of lipophilic side chain in the 1-position led to 100-fold more potent inhibitors. Functional assays on isolated perfused rat liver with compound 29i, a representative of the more potent derivatives, showed a dose-dependent inhibition of gluconeogenesis and glycogenolyosis, suggesting glucose-6-phosphatase as the locus of interference of the compound for inhibition of hepatic glucose production also in the isolated organ model. Gl-6-P translocase inhibitors may be useful for the reduction of inappropriately high rates of hepatic glucose output often found in non-insulin-dependent diabetes.read more
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Journal ArticleDOI
Chlorogenic acid (CGA): A pharmacological review and call for further research.
Muhammad Naveed,Veghar Hejazi,Muhammad Abbas,Asghar Ali Kamboh,Ghulam Jilany Khan,Muhammad Shumzaid,Fawwad Ahmad,Daryoush Babazadeh,Xia FangFang,Faezeh Modarresi-Ghazani,Li Wenhua,Zhou Xiaohui,Zhou Xiaohui +12 more
TL;DR: It is speculated that CGA can perform crucial roles in lipid and glucose metabolism regulation and thus help to treat many disorders such as hepatic steatosis, cardiovascular disease, diabetes, and obesity as well.
Journal ArticleDOI
Mexican plants with hypoglycaemic effect used in the treatment of diabetes
TL;DR: A review of species commonly used in México in the treatment of diabetes mellitus, highlighting the current knowledge about these botanicals, but also the enormous gaps in knowledge as it relates to the species' toxicology, the pharmacokinetics of its active constituents and their metabolism.
Journal ArticleDOI
Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and dyslipidemia: a review
Majambu Mbikay,Majambu Mbikay +1 more
TL;DR: Before M. oleifera leaf formulations can be recommended as medication in the prevention or treatment of diabetes and CVD, it is necessary that the scientific basis of their efficacy, the therapeutic modalities of their administration and their possible side effects be more rigorously determined.
Journal ArticleDOI
Antiobesity effects of yerba maté extract (Ilex paraguariensis) in high-fat diet-induced obese mice.
Demétrius Paiva Arçari,Waldemar Bartchewsky,Tanila Wood dos Santos,Karim A. Oliveira,Alexandre Funck,José Pedrazzoli,M F F Souza,Mario J.A. Saad,Deborah H. M. Bastos,Alessandra Gambero,Patrícia de Oliveira Carvalho,Marcelo Lima Ribeiro +11 more
TL;DR: The data show that yerba maté extract has potent antiobesity activity in vivo, and it is observed that the treatment had a modulatory effect on the expression of several genes related to obesity.
Journal ArticleDOI
Quinides of Roasted Coffee Enhance Insulin Action in Conscious Rats
Jane Shearer,Adriana Farah,Tomas de Paulis,Deanna P. Bracy,R. Richard Pencek,Terry E. Graham,David H. Wasserman +6 more
TL;DR: It is demonstrated that DIFEQ increases whole-body glucose disposal independently of skeletal muscle Rg, and decaffeinated coffee extract or 3,4-diferuloyl-1,5-quinide did not affect heart rate, blood pressure, plasma nonesterified fatty acids or liver aminotransferase activity.
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Journal ArticleDOI
Chlorogenic acid and synthetic chlorogenic acid derivatives : Novel inhibitors of hepatic glucose-6-phosphate translocase
Horst Hemmerle,Burger Hans-Joerg,Peter Below,Gerrit Schubert,Robert Rippel,Schindler Peter,Erich F. Paulus,Andreas W. Herling +7 more
TL;DR: Functional assays on isolated perfused rat liver with compound 29i showed a dose-dependent inhibition of gluconeogenesis and glycogenolyosis, suggesting glucose-6-phosphatase as the locus of interference of the compound for inhibition of hepatic glucose production also in the isolated organ model.
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